THE NATIONAL ACADEMIES OF SCIENCES, ENGINEERING, AND MEDICINE
Division on Earth and Life Studies
Board on Environmental Studies and Toxicology
Committee to Review Advances Made to the IRIS Process
Progress Toward Transforming the Integrated Risk Information System (IRIS) Program:
A 2018 Evaluation
Over the past several years, the US Environmental Protection Agency (EPA) has been transforming the procedures of its Integrated Risk Information System (IRIS), a program that produces hazard and dose‒response assessments of environmental chemicals and derives toxicity values that can be used to estimate risks posed by exposures to them. The transformation was initiated after suggestions for program reforms were provided in a 2011 report
from the National Academies of Sciences, Engineering, and Medicine that reviewed a draft IRIS assessment of formaldehyde. In 2014, the National Academies released a report
that reviewed the IRIS program and evaluated the changes implemented in it since the 2011 report.
Since 2014, new leadership of EPA’s National Center for Environmental Assessment (NCEA) and IRIS program has instituted even more substantive changes in the IRIS program in response to the recommendations in the 2014 report. This new report reviews the EPA’s progress toward addressing the past recommendations.