Improving Cancer Diagnosis and Care: The Clinical Application of Computational Methods in Precision Oncology: A Workshop

When: October 29, 2018 - October 30, 2018 (8:00 AM Eastern)
Where: Keck Center (100) • 500 Fifth St. NW, Washington, DC 20001

Topics Biomedical and Health Research, Diseases, Health Services, Coverage, and Access, Quality and Patient Safety
Activity: National Cancer Policy Forum
Boards: Board on Health Care Services

The National Cancer Policy Forum developed a 2-workshop series to examine strategies to improve cancer diagnosis and care. The first workshop focused on patient access to expertise and technologies in oncologic imaging and pathology (held on February 12 – 13, 2018). The second workshop, held on October 29 – 30, 2018, examined the use of high-dimensional omics data and computational methods in precision oncology care. 

A major component of high-quality cancer care is to ensure the delivery of the right treatment to the right patient at the right time. Advances in biomedicine have contributed to the growing use of precision oncology therapies that target specific abnormalities in a patient’s cancer, facilitated in part by the development of large-scale biologic databases, computational methods, and omics technologies that enable molecular characterization of patients’ cancers. 

In current clinical practice, oncologists are increasingly using diagnostic tests to determine cancer treatment plans based on the molecular underpinnings of an individual patient’s cancer (often in a one-biomarker/one-treatment manner). Since the development of cancer is almost always multi-genic and multi-clonal, the cancer community is examining opportunities to develop, validate, and use multiplexed omics tests (e.g., multi-parameter/multi-treatment predictions) to better tailor cancer treatments and improve patient outcomes.

As high-complexity omics data and testing become more widely available, the cancer community needs clear direction on how to apply complex computational biology methods in precision cancer care to ensure both patient safety and the integrity of scientific findings.

The workshop featured invited presentations and panel discussions on topics that included: 
challenges and opportunities to use omics data to develop precision medicine approaches and technologies in cancer care
potential standards and best practices for computational software and methodological approaches for the use of big data to inform the care of patients with cancer, especially in regard to multi-parameter/multi-treatment testing and interpretation 
•potential opportunities to improve the translation of omics technologies into oncology practice

The National Cancer Policy Forum is collaborating with the Board on Mathematical Sciences and Analytics to conduct this workshop.

Confirmed Moderators, Speakers, & Panelists

Amy Abernethy, Flatiron Health

Lukas Amler, Genentech
Atul Butte, University of California, San Francisco
Joseph Chin, Centers for Medicare & Medicaid Services
David Chu, Institute for Defense Analyses
Christopher Cogle, University of Florida
Kadija Ferryman, Data & Society Research Institute
Keith Flaherty, Massachusetts General Hospital Cancer Center
Constantine Gatsonis, Brown University
Steven Goodman, Stanford School of Medicine 
Hedvig Hricak, Memorial Sloan Kettering Cancer Center 
Galen Joseph, University of California, San Francisco
Michael Kelley, Duke University and Department of Veterans Affairs
Sean Khozin, Food and Drug Administration
Mia Levy, Vanderbilt University
David Magnus, Stanford University and All of Us Research Program
Deven McGraw, Ciitizen
Howard McLeod, Moffitt Cancer Center
Lisa McShane, National Cancer Institute 
Lincoln Nadauld, Intermountain Healthcare
Lee N. Newcomer, Lee N. Newcomer Consulting
George "Holt" Oliver, Parkland Center for Clinical Innovation
Giovanni Parmigiani, Dana-Farber Cancer Institute 
Bray Patrick-Lake, Duke University and All of Us Research Program
Nicholas Petrick, Food and Drug Administration
Richard Schilsky, American Society of Clinical Oncology

Pratik Shah, MIT Media Lab

Frank F. Weichold, Food and Drug Administration

Planning Committee Members

Christopher Cogle, University of Florida (chair)
Amy Abernethy, Flatiron Health 
Constantine Gatsonis, Brown University
Lori Hoffman Högg, Department of Veterans Affairs
Hedvig Hricak, Memorial Sloan Kettering Cancer Center
Samir N. Khleif, Georgetown University
Mia Levy, Vanderbilt-Ingram Cancer Center
David Magnus, Stanford University and All of Us Research Program
Martin J. Murphy, CEO Roundtable on Cancer
Bakul Patel, Food and Drug Administration
Robert Winn, University of Illinois at Chicago

The live webcast will be posted here on the workshop dates.



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