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Genomics, proteomics, and other branches of molecular bioscience offer the possibility of greater precision in medical care by tailoring therapies to patients' genetic or molecular profiles. But some clinical tests based on "omics" research, including tests developed by researchers at Duke University to select chemotherapy for cancer patients, have proved invalid. Evolution of Translational Omics: Lessons Learned and the Path Forward, a new report from the Institute of Medicine, recommends steps to help avoid future problems associated with moving omics-based discoveries from the lab to clinical settings.