About Publications

Publications from the National Academies of Sciences, Engineering, and Medicine provide objective and straightforward advice to decision makers and the public. This site includes Health and Medicine Division (HMD) publications released after 1998. A complete list of HMD’s publications from its establishment in 1970 to the present is available as a PDF.


  • Establishing Effective Patient Navigation Programs in ... Released: May 24, 2018
    Delivering high-quality cancer care to all patients presents numerous challenges, including difficulties with ensuring patients have access to well-coordinated care across the cancer continuum. Patient navigation programs are designed to promote access to timely cancer diagnosis and care by addressing barriers to cancer care, such as challenges with health literacy, language barriers affecting comprehension of diagnosis and treatment, lack of transportation, or insufficient insurance coverage. Patient navigation programs were originally designed—and are still primarily directed at—improving cancer care among vulnerable patients.
  • Long-Term Survivorship Care After Cancer Treatment ... Released: April 27, 2018
    To examine progress in cancer survivorship care since the consensus report From Cancer Patient to Cancer Survivor: Lost in Transition, the National Cancer Policy Forum held a workshop, “Long-Term Survivorship Care After Cancer Treatment” on July 24 and July 25, 2017, in Washington, DC. Workshop presentations and discussions highlighted potential opportunities to improve the planning, management, and delivery of cancer survivorship care.
  • Advancing Therapeutic Development for Pain and Opioid Use ... Released: March 23, 2018
    Chronic pain is one of the most prevalent, costly, and disabling health conditions in the United States. In parallel with increasing recognition of the need to treat chronic pain, the opioid epidemic has emerged as a growing public health emergency. In 2017, the National Institutes of Health began exploring public-private partnerships to develop solutions to the opioid crisis and cut in half the time it takes to develop non-addictive analgesics. To help inform this effort, the National Academies’ Forum on Neuroscience and Nervous Systems Disorders hosted a public workshop that brought together experts and stakeholders from academia, federal agencies, advocacy organizations, and companies developing therapeutics for pain and opioid use disorders.
  • Implementing and Evaluating Genomic Screening Programs ... Released: March 16, 2018
    Genomic applications are being integrated into a broad range of clinical and research activities at health care systems across the United States. The genomics-based screening programs are clinical screening programs that examine genes or variants in unselected populations in order to identify individuals who are at an increased risk for a particular health concern (e.g., diseases, adverse drug outcomes) and who might benefit from clinical interventions.
  • Enabling Novel Treatments for Nervous System Disorders by ... Released: March 08, 2018
    The blood-brain barrier (BBB) presents a special challenge to the development of therapeutics for many central nervous system (CNS) disorders. Far from acting simply as a physical barrier, the BBB is a complex dynamic system involving several cell types, passive and active transport mechanisms, and adaptive function to control the exchange of substances between the blood and the CNS. Few therapeutic agents readily traverse the BBB to reach the brain or spinal cord, including most small molecule drugs and the vast majority of large molecules such as proteins.
  • Examining the Impact of Real-World Evidence on Medical ... Released: February 12, 2018
    Randomized, controlled clinical trials (RCTs) have traditionally served as the gold standard for evidence generation in support of medical product development and evaluation. However, it is increasingly recognized that RCTs have inherent limitations, particularly with regard to generalizability, and time and monetary investment. Data from sources supplemental to RCTs, such as safety surveillance, observational studies, registries, claims, or patient-centered outcomes research, would be valuable to support biomedical research, including medical product development and evaluation.
  • Review of NASA's Evidence Reports on Human Health Risks ... Released: January 10, 2018
    The National Academies of Science, Engineering and Medicine, at the request of the National Aeronautics & Space Administration (NASA) and with guidance from the National Academies’ Standing Committee on Aerospace Medicine and the Medicine of Extreme Environments, established a committee to review NASA’s Evidence Reports on Human Health Risks. These evidence reports focus on human health risks for long-duration and exploration spaceflights.
  • Incorporating Weight Management and Physical Activity ... Released: December 01, 2017
    The National Cancer Policy Forum held a public workshop in February 2017 to examine the potential for weight management and physical activity interventions to improve health outcomes for cancer survivors. The workshop, Incorporating Weight Management and Physical Activity throughout the Cancer Care Continuum, highlighted the current evidence base, gaps in knowledge, and research needs on the associations among obesity, physical activity, weight management, and health outcomes for cancer survivors.
  • Navigating the Manufacturing Process and Ensuring the ... Released: October 26, 2017
    Regenerative medicine holds the potential to create living, functional cells and tissues which can be used to repair or replace those that have suffered irreparable damage due to disease, age, traumatic injury, or congenital defects. Although regenerative medicine has the potential to result in health and economic benefits, this relatively new field faces unique manufacturing and regulatory challenges in the development of novel therapies that are both safe and effective. Some of these issues arise because regenerative medicine therapies produce and rely on living cells and tissues, which are inherently variable, even within a single type of cell.
  • Examining Challenges and Possible Strategies to Strengthen ... Released: October 18, 2017
    As the United States continues to adapt to a more digital, mobile, and interconnected world, health care and public health professionals have sought to better prepare for and respond to long-standing and emerging threats to the nation’s health security. Health security is the collective effort to prevent, protect against, mitigate, respond to, and recover from the health consequences of natural, man-made, and technological disasters.