Publications from the National Academies of Sciences, Engineering, and Medicine provide objective and straightforward advice to decision makers and the public. This site includes Health and Medicine Division (HMD) publications released after 1998. A complete list of HMD’s publications from its establishment in 1970 to the present is available as a PDF.
Advancing Therapeutic Development for Pain and Opioid Use ...
Released: March 23, 2018
Chronic pain is one of the most prevalent, costly, and disabling health conditions in the United States. In parallel with increasing recognition of the need to treat chronic pain, the opioid epidemic has emerged as a growing public health emergency. In 2017, the National Institutes of Health began exploring public-private partnerships to develop solutions to the opioid crisis and cut in half the time it takes to develop non-addictive analgesics. To help inform this effort, the National Academies’ Forum on Neuroscience and Nervous Systems Disorders hosted a public workshop that brought together experts and stakeholders from academia, federal agencies, advocacy organizations, and companies developing therapeutics for pain and opioid use disorders.
Enabling Novel Treatments for Nervous System Disorders by ...
Released: March 08, 2018
The blood-brain barrier (BBB) presents a special challenge to the development of therapeutics for many central nervous system (CNS) disorders. Far from acting simply as a physical barrier, the BBB is a complex dynamic system involving several cell types, passive and active transport mechanisms, and adaptive function to control the exchange of substances between the blood and the CNS. Few therapeutic agents readily traverse the BBB to reach the brain or spinal cord, including most small molecule drugs and the vast majority of large molecules such as proteins.
Combating Antimicrobial Resistance: A One Health Approach ...
Released: December 08, 2017
To build on previous work, to explore developments since the last workshop was convened, and to help parlay knowledge into immediate action, an ad hoc planning committee, under the auspices of the Forum of Microbial Threats at the National Academies, planned a 2-day public workshop Combating Antimicrobial Resistance: A One Health Approach to a Global Threat. The workshop explored issues of antimicrobial resistance through the lens of One Health, which is a collaborative approach of multiple disciplines—working locally, nationally, and globally—for strengthening systems to counter infectious diseases and related issues that threaten human, animal, and environmental health, with an end point of improving global health and achieving gains in development.
Incorporating Weight Management and Physical Activity ...
Released: December 01, 2017
The National Cancer Policy Forum held a public workshop in February 2017 to examine the potential for weight management and physical activity interventions to improve health outcomes for cancer survivors. The workshop, Incorporating Weight Management and Physical Activity throughout the Cancer Care Continuum, highlighted the current evidence base, gaps in knowledge, and research needs on the associations among obesity, physical activity, weight management, and health outcomes for cancer survivors.
Making Medicines Affordable: A National Imperative : Health ...
Released: November 30, 2017
Over the past several decades, the biopharmaceutical sector in the United States has been successful in developing and delivering effective drugs for improving health and fighting disease, and many medical conditions that were long deemed untreatable can now be cured or managed effectively. At the same time, spending on prescription drugs has been rising dramatically, to the point that many individuals have difficulty paying for the drugs that they or their family members need.
Models and Strategies to Integrate Palliative Care Principles ...
Released: October 24, 2017
The Roundtable on Quality Care for People with Serious Illness hosted a full-day workshop on April 27, 2017 to explore Models and Strategies to Integrate Palliative Care Principles into Care for People with Serious Illness. The workshop aimed to highlight innovative models of community-based care for people of all ages facing serious illness.
Exploring the Translation of the Results of Hurricane Sandy ...
Released: September 15, 2017
The workshop Translating the Results of Hurricane Sandy Research Grants into Policy and Operations was convened on July 20, 2017, in Washington, DC, by the Health and Medicine Division of the National Academies of Sciences, Engineering, and Medicine with the objective of exploring key findings from published Hurricane Sandy research grant projects, examining the impact of the scientific findings on disaster policy and operations, and discussing opportunities to translate the research findings to future preparedness response and recovery efforts.
Biomarkers of Neuroinflammation: Proceedings of a Workshop ...
Released: September 15, 2017
Innate and adaptive immunity have become very important areas of investigation for psychiatric, neurologic, and neurodevelopmental disorders, and neurodegeneration resulting from traumatic brain injury. To address these gaps in understanding mechanisms and how to translate that understanding into therapeutics, the Forum on Neuroscience and Nervous System Disorders of the National Academies of Sciences, Engineering, and Medicine convened a workshop on March 20–21, 2017, bringing together key leaders in the field from industry, academia, and governmental agencies to explore the role and mechanisms of neuroinflammation in a variety of central nervous system diseases.
Guiding Principles for Developing Dietary Reference Intakes ...
Released: August 03, 2017
For decades, nutrient intake recommendations have been issued through the Dietary Reference Intakes (DRIs) established by consensus committees of the Institute of Medicine, and now the National Academies of Sciences, Engineering, and Medicine (the National Academies). For each nutrient (e.g., vitamins, minerals, water, electrolytes, carbohydrate, or protein) deemed essential, DRI committees reviews the scientific literature to help inform nutrition standards of adequacy and toxicity for groups of people of different genders and at different life stages. These DRIs are used for planning and assessing the diets of apparently healthy individuals and groups.
The Drug Development Paradigm in Oncology: Proceedings ...
Released: July 24, 2017
Advances in cancer research have led to an improved understanding of the molecular mechanisms underpinning the development of cancer and how the immune system responds to cancer. This influx of research has led to an increasing number and variety of cancer therapies in the drug development pipeline. Compared with standard chemotherapies, these new cancer therapies may demonstrate evidence of benefit at an earlier stage of development.