About Publications

Publications from the National Academies of Sciences, Engineering, and Medicine provide objective and straightforward advice to decision makers and the public. This site includes Health and Medicine Division (HMD) publications released after 1998. A complete list of HMD’s publications from its establishment in 1970 to the present is available as a PDF.


  • Therapeutic Development in the Absence of Predictive Animal ... Released: March 10, 2017
    Despite the high prevalence and burden of nervous system disorders, development of new therapeutics lags behind other disease areas. Gaps in understanding the underlying pathophysiology, a dearth of biomarkers, and limitations in the capacity of animal models to predict drug efficacy for human brain disorders have contributed to a high rate of late stage failures in drug development and decreased investment in neuroscience research programs at pharmaceutical companies. On September 12-13, 2016, the National Academies of Sciences, Engineering, and Medicine’s Forum on Neuroscience and Nervous System Disorders hosted a public workshop to explore opportunities to accelerate drug development absent predictive animal models.
  • International Perspectives on Integrating Ethical, Legal, and ... Released: January 09, 2017
    Emerging neurotechnologies—devices and techniques designed to collect information about the brain or affect its function—are becoming increasingly important due to scientific and technological advances and a persistent need to develop effective therapies to address the large global burden of neurological and psychiatric disease. The Organisation for Economic Co-operation and Development (OECD)—in collaboration with Arizona State University and the National Academies of Sciences, Engineering, and Medicine—held a workshop in Washington, DC, on Neurotechnology and Society: Strengthening Responsible Innovation in Brain Science.
  • Big Data and Analytics for Infectious Disease Research ... Released: December 08, 2016
    With the amount of data in the world exploding, big data could generate significant value in the field of infectious disease. The Forum on Microbial Threats determined that the broader applications and implications of big data in these areas ought to be explored, where “big data” refers to any voluminous amount of structured, semi-structured, and unstructured data that has the potential to be mined for insights and information.
  • The Ebola Epidemic in West Africa: Proceedings of a ... Released: December 06, 2016
    The most recent Ebola epidemic that began in late 2013 alerted the entire world to the gaps in infectious disease emergency preparedness and response. Building on previous outbreak workshops, the Forum on Microbial Threats convened this workshop to understand the recent developments in incidence, prevalence, and intervention strategies used to mitigate the disease in an increasingly interconnected world. Recognizing the opportunity to learn from the countless lessons of this epidemic, this workshop discussed the challenges to successful outbreak responses at the scientific, clinical, and global health levels.
  • Developing Multimodal Therapies for Brain Disorders ... Released: November 18, 2016
    Califf was the keynote speaker at a workshop on multimodality therapies for brain disorders, convened by the National Academies of Sciences, Engineering, and Medicine’s Forum on Neuroscience and Nervous Systems Disorders. The workshop brought together key stakeholders to examine the general principles underlying multimodal therapies and to explore challenges, potential barriers, and opportunities for their development from multiple perspectives, including scientific, clinical, regulatory, and financial. These proceedings chronicle the presentations and discussions at the workshop.
  • Implementation of Lung Cancer Screening: Proceedings of a ... Released: November 17, 2016
    Lung cancer is the leading cause of cancer-related death in the United States; each year, more people die from lung cancer than from colon, breast, and prostate cancers combined. There has been a push to develop and implement screening strategies for the early detection of lung cancer. The National Lung Screening Trial evaluated the effectiveness of annual screening with low-dose computed tomography to reduce lung cancer mortality among individuals at high risk.
  • Making Eye Health a Population Health Imperative: Vision for ... Released: September 15, 2016
    Despite the importance of eyesight, millions of people grapple with undiagnosed or untreated vision impairments—ranging from mild conditions to total blindness—and eye and vision health remain relatively absent from national health priority lists, says a new report from the National Academies of Sciences, Engineering, and Medicine.
  • Neuroscience Trials of the Future: Proceedings of a Workshop ... Released: August 19, 2016
    On March 3–4, 2016, the National Academies of Sciences, Engineering, and Medicine’s Forum on Neuroscience and Nervous System Disorders held a workshop in Washington, DC, bringing together key stakeholders to discuss opportunities for improving the integrity, efficiency, and validity of clinical trials for nervous system disorders.
  • Policy Issues in the Clinical Development and Use of ... Released: July 19, 2016
    To examine challenges in the development and implementation of immunotherapies into clinical practice and explore strategies to overcome them, the National Cancer Policy Forum of the National Academies of Sciences, Engineering, and Medicine held the workshop “Policy Issues in the Clinical Development and Use of Immunotherapy for Cancer” on February 29 and March 1, 2016, in Washington, DC.
  • Health Risks of Indoor Exposure to Particulate Matter ... Released: July 06, 2016
    The health effects of outdoor exposure to particulate matter (PM) are the subject of both research attention and regulatory action. Although much less studied to date, indoor exposure to PM—which can result from particles infiltrating from the outdoors and from various indoor sources including candles, cooking, and smoking—is gaining attention as a potential source of adverse health effects. The U.S. Environmental Protection Agency recently commissioned the National Academies of Sciences, Engineering, and Medicine to hold a workshop examining what is known about indoor exposure to PM, examining sources of particles, their interaction with other elements of the indoor environment, exposure levels indoors, potential health concerns, ways to limit exposure, vulnerable populations, and means of communicating exposure risks and strategies to reduce exposures.