About Publications

Publications from the National Academies of Sciences, Engineering, and Medicine provide objective and straightforward advice to decision makers and the public. This site includes Health and Medicine Division (HMD) publications released after 1998. A complete list of HMD’s publications from its establishment in 1970 to the present is available as a PDF.


  • Therapeutic Development in the Absence of Predictive Animal ... Released: March 10, 2017
    Despite the high prevalence and burden of nervous system disorders, development of new therapeutics lags behind other disease areas. Gaps in understanding the underlying pathophysiology, a dearth of biomarkers, and limitations in the capacity of animal models to predict drug efficacy for human brain disorders have contributed to a high rate of late stage failures in drug development and decreased investment in neuroscience research programs at pharmaceutical companies. On September 12-13, 2016, the National Academies of Sciences, Engineering, and Medicine’s Forum on Neuroscience and Nervous System Disorders hosted a public workshop to explore opportunities to accelerate drug development absent predictive animal models.
  • International Perspectives on Integrating Ethical, Legal, and ... Released: January 09, 2017
    Emerging neurotechnologies—devices and techniques designed to collect information about the brain or affect its function—are becoming increasingly important due to scientific and technological advances and a persistent need to develop effective therapies to address the large global burden of neurological and psychiatric disease. The Organisation for Economic Co-operation and Development (OECD)—in collaboration with Arizona State University and the National Academies of Sciences, Engineering, and Medicine—held a workshop in Washington, DC, on Neurotechnology and Society: Strengthening Responsible Innovation in Brain Science.
  • Strengthening the workforce to Support Community Living and ... Released: November 22, 2016
    As the demographics of the United States shift toward a population that is made up of an increasing percentage of older adults and people with disabilities, the workforce that supports and enables these individuals is also shifting to meet the demands of this population. To better understand how the nation’s workforce can be strengthened to meet these demands, the Health and Medicine Division and the Division of Behavioral and Social Sciences and Education of the National Academies of Sciences, Engineering, and Medicine, convened a public workshop with support from multiple sponsors.
  • Developing Multimodal Therapies for Brain Disorders ... Released: November 18, 2016
    Califf was the keynote speaker at a workshop on multimodality therapies for brain disorders, convened by the National Academies of Sciences, Engineering, and Medicine’s Forum on Neuroscience and Nervous Systems Disorders. The workshop brought together key stakeholders to examine the general principles underlying multimodal therapies and to explore challenges, potential barriers, and opportunities for their development from multiple perspectives, including scientific, clinical, regulatory, and financial. These proceedings chronicle the presentations and discussions at the workshop.
  • Families Caring for an Aging America : Health and Medicine ... Released: September 13, 2016
    At least 17.7 million individuals in the United States are providing care and support to an older parent, spouse, friend, or neighbor who needs help because of a limitation in their physical, mental, or cognitive functioning.
  • Neuroscience Trials of the Future: Proceedings of a Workshop ... Released: August 19, 2016
    On March 3–4, 2016, the National Academies of Sciences, Engineering, and Medicine’s Forum on Neuroscience and Nervous System Disorders held a workshop in Washington, DC, bringing together key stakeholders to discuss opportunities for improving the integrity, efficiency, and validity of clinical trials for nervous system disorders.
  • Meeting the Dietary Needs of Older Adults Exploring the ... Released: July 14, 2016
    On October 28-29, 2015, the Food and Nutrition Board convened a workshop, Meeting the Dietary Needs of Older Adults. The workshop was designed to examine factors in the physical, social, and cultural environment that affect the ability of older adults to meet their daily dietary needs. This document summarizes the presentations and discussions from the workshop.
  • Policy and Research Needs to Maximize Independence and ... Released: March 04, 2016
    Living independently and participating in one’s community are priorities for many people. In many regions across the United States, there are programs that support and enable people with disabilities and older adults to live in the setting of their choosing and to participate fully in their communities.
  • Meeting the Dietary Needs of Older Adults: Workshop in Brief ... Released: February 01, 2016
    On October 28–29, 2015, the National Academies of Sciences, Engineering, and Medicine Food and Nutrition Board convened a workshop in Washington, DC, to examine factors in the physical, social, and cultural environment that affect the ability of older adults to meet their daily dietary needs
  • Considerations for the Design of a Systemic Review of ... Released: December 29, 2015
    The National Institutes of Health- and many other organizations and individuals worldwide- are interested in the state of the science of preventing Alzheimer's disease, mild cognitive impairment, and age-related cognitive decline.