Publications from the National Academies of Sciences, Engineering, and Medicine provide objective and straightforward advice to decision makers and the public. This site includes Health and Medicine Division (HMD) publications released after 1998. A complete list of HMD’s publications from its establishment in 1970 to the present is available as a PDF.
Improving the Utility and Translation of Animal Models for ...
Released: February 08, 2013
Animal models have provided significant information about the biology of nervous system disorders and have helped in the development of therapeutics; limitations, however, have also been identified. Effective treatment options that are also low in side effects are still lacking for many diseases. Many therapeutics show promise in preclinical animal models but then fail to produce expected results when tested in humans. The IOM held a workshop to discuss potential opportunities for maximizing the translation of effective therapies from animal models to clinical practice.
US Health in International Perspective: Shorter Lives, Poorer ...
Released: January 09, 2013
The United States is among the wealthiest nations in the world, but it is far from the healthiest. For many years, Americans have been dying at younger ages than people in almost all other high-income countries. To gain a better understanding of this problem, the NIH asked the National Research Council and the IOM to investigate potential reasons for the U.S. health disadvantage and to assess its larger implications. No single factor can fully explain the U.S. health disadvantage. Without action to reverse current trends, the health of Americans will probably continue to fall behind that of people in other high-income countries.
The Mental Health and Substance Use Workforce for Older ...
Released: July 10, 2012
At least 5.6 million to 8 million – nearly one in five – older adults in America have one or more mental health and substance use conditions, which present unique challenges for their care. With the number of adults age 65 and older projected to soar from 40.3 million in 2010 to 72.1 million by 2030, the aging of America holds profound consequences for the nation. Following its 2008 report highlighting the urgency of expanding and strengthening the geriatric health care workforce, the IOM was asked by the Department of Health and Human Services to undertake a complementary study on the geriatric mental health and substance use workforce. An expert committee assessed the needs of this population and the workforce that serves it.
International Animal Research Regulations: Impact on ...
Released: May 29, 2012
Animals are widely used in neuroscience research to explore biological mechanisms of nervous system function, to identify the genetic basis of disease states, and to provide models of human disorders and diseases for the development of new treatments. To ensure the humane care and use of animals, numerous laws, policies, and regulations are in place governing the use of animals in research, and certain animal regulations have implications specific to neuroscience research. To consider animal research regulations from a global perspective, the IOM held a workshop that brought together key stakeholders to discuss current and emerging trends in animal regulations as they apply to the neurosciences.
Nutrition and Healthy Aging in the Community - Workshop ...
Released: March 20, 2012
As the baby boomers age, the population of Americans over the age of 65 is expected to increase to about 55 million in 2020. The increase in the older population will result in a surging demand for the delivery of services and create new challenges for older people, their caregivers, and nutrition and social services professionals who seek to ensure these services’ availability. The IOM held a workshop to highlight topics related to community-based delivery of nutrition services for older adults and to identify nutrition interventions and model programs which support the transition to home care as well as health and independent living in the community.
Alzheimer's Diagnostic Guideline Validation: Exploration of ...
Released: February 16, 2012
Scientific advances over the last decade now indicate that Alzheimer’s disease is a continuous, progressive cognitive disease, most likely beginning many years before dementia is apparent. To discuss the next steps in validating new diagnostic guidelines for Alzheimer’s disease, the IOM Forum on Neuroscience and Nervous System Disorders hosted a public workshop session at the Alzheimer’s Association International Conference.
Glutamate-Related Biomarkers in Drug Development for ...
Released: June 08, 2011
Problems with how the neurotransmitter glutamate functions in the brain have been linked to a wide variety of disorders, including schizophrenia, Alzheimer’s, substance abuse, and traumatic brain injury. Efforts to understand, treat, and prevent glutamate-related disorders can be aided by the identification of valid biomarkers. The IOM’s Forum on Neuroscience and Nervous System Disorders held a workshop June 21-22, 2010, to explore ways to accelerate the development, validation, and implementation of such biomarkers.
Sex Differences and Implications for Translational ...
Released: December 10, 2010
Biological differences between the sexes influence not only individual health but also public health, biomedical research, and health care. The IOM held a workshop March 8-9, 2010, to discuss sex differences and their implications for translational neuroscience research, which bridges the gap between scientific discovery and application.
Future Opportunities to Leverage the Alzheimer's Disease ...
Released: December 10, 2010
Nearly 5.3 million Americans are living with Alzheimer’s disease, and 26.6 million people are affected worldwide. The Alzheimer’s Disease Neuroimaging Initiative (ADNI), a public-private partnership, provides a publicly available, international database of clinical and imaging data to foster research and collaboration on Alzheimer’s research worldwide. The IOM held a workshop on July 12, 2010, to explore opportunities to use information from and partnerships formed because of ADNI to continue to improve the understanding and treatment of Alzheimer’s disease.
Mental, Neurological, and Substance Use Disorders in Sub ...
Released: July 08, 2010
Millions of people in sub-Saharan Africa suffer from mental, neurological, and substance use (MNS) disorders, and most do not have the resources to obtain treatment. The Uganda National Academy of Sciences and the IOM hosted a workshop to discuss the state of care for MNS disorders in sub-Saharan Africa.