Publications from the National Academies of Sciences, Engineering, and Medicine provide objective and straightforward advice to decision makers and the public. This site includes Health and Medicine Division (HMD) publications released after 1998. A complete list of HMD’s publications from its establishment in 1970 to the present is available as a PDF.
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Navigating the Manufacturing Process and Ensuring the ...
Released: October 26, 2017
Regenerative medicine holds the potential to create living, functional cells and tissues which can be used to repair or replace those that have suffered irreparable damage due to disease, age, traumatic injury, or congenital defects. Although regenerative medicine has the potential to result in health and economic benefits, this relatively new field faces unique manufacturing and regulatory challenges in the development of novel therapies that are both safe and effective. Some of these issues arise because regenerative medicine therapies produce and rely on living cells and tissues, which are inherently variable, even within a single type of cell.
Models and Strategies to Integrate Palliative Care Principles ...
Released: October 24, 2017
The Roundtable on Quality Care for People with Serious Illness hosted a full-day workshop on April 27, 2017 to explore Models and Strategies to Integrate Palliative Care Principles into Care for People with Serious Illness. The workshop aimed to highlight innovative models of community-based care for people of all ages facing serious illness.
Examining Challenges and Possible Strategies to Strengthen ...
Released: October 18, 2017
As the United States continues to adapt to a more digital, mobile, and interconnected world, health care and public health professionals have sought to better prepare for and respond to long-standing and emerging threats to the nation’s health security. Health security is the collective effort to prevent, protect against, mitigate, respond to, and recover from the health consequences of natural, man-made, and technological disasters.
Protecting the Health and Well-Being of Communities in a ...
Released: October 06, 2017
On March 13, 2017, the Roundtable on Environmental Health Sciences, Research, and Medicine and the Roundtable on Population Health Improvement jointly convened a 1-day public workshop, Protecting the Health and Well-being of Communities in a Changing Climate in Washington, DC. The workshop was intended to exploring the implications of climate change for population health and the potential strategies that public health, environmental health, health care, and related stakeholders can implement to help communities and regions address and mitigate health effects.
Biomarkers of Neuroinflammation: Proceedings of a Workshop ...
Released: September 15, 2017
Innate and adaptive immunity have become very important areas of investigation for psychiatric, neurologic, and neurodevelopmental disorders, and neurodegeneration resulting from traumatic brain injury. To address these gaps in understanding mechanisms and how to translate that understanding into therapeutics, the Forum on Neuroscience and Nervous System Disorders of the National Academies of Sciences, Engineering, and Medicine convened a workshop on March 20–21, 2017, bringing together key leaders in the field from industry, academia, and governmental agencies to explore the role and mechanisms of neuroinflammation in a variety of central nervous system diseases.
Communicating Clearly About Medicines: Proceedings of a ...
Released: September 08, 2017
The Roundtable on Health Literacy of the National Academies of Sciences, Engineering, and Medicine convened a workshop on communicating clearly about medicines. The workshop focused on the clarity of written information given to patients and consumers as printed or digital materials. The workshop was organized around presentations and panel discussions that explored the design of health-literate written materials and examples that illustrated implementation of research into the development of these materials. The workshop rapporteurs in brief have prepared this proceedings as a factual summation of the session discussions.
The Drug Development Paradigm in Oncology: Proceedings ...
Released: July 24, 2017
Advances in cancer research have led to an improved understanding of the molecular mechanisms underpinning the development of cancer and how the immune system responds to cancer. This influx of research has led to an increasing number and variety of cancer therapies in the drug development pipeline. Compared with standard chemotherapies, these new cancer therapies may demonstrate evidence of benefit at an earlier stage of development.
Building Sustainable Financing Structures for Population ...
Released: July 18, 2017
A workshop held on October 19, 2016 explored financing structures from non-health sectors that provide lessons and examples useful for cross-sector efforts to change community conditions that influence population health. The workshop showcased speakers with expertise in clean energy financing, housing, and justice reinvestment. Presentations and discussion included examples of the ways in which financing approaches (e.g., gain sharing agreements, taxes, credits) can be designed to achieve co-benefits, or win-wins, for health and other domains.
Integrating the Patient and Caregiver Voice into Serious ...
Released: July 14, 2017
Millions of people—infants, children, adults, and their families—are currently coping with serious illness in the United States. Efforts are intensifying to improve overall care quality through the delivery of person-centered and family-oriented services, for patients of all ages and across disease stages, care settings, and specialties. While aging Baby Boomers are increasing the proportion of patients in the Medicare population over time, the sickest and most vulnerable patients needing health system support and other services to meet their complex needs can be found across the age spectrum and in a broad range of care settings, from perinatal care to geriatric care.
Enabling Precision Medicine: The Role of Genetics in Clinical ...
Released: July 10, 2017
Those involved in the drug development process face challenges of efficiency and overall sustainability due in part to high research costs, lengthy development timelines, and late-stage drug failures. Novel clinical trial designs that enroll participants based on their genetics represent a potentially disruptive change that could improve patient outcomes, reduce costs associated with drug development, and further realize the goals of precision medicine. On March 8, 2017, the Forum on Drug Discovery, Development, and Translation and the Roundtable on Genomics and Precision Health hosted the workshop Enabling Precision Medicine: The Role of Genetics in Clinical Drug Development.