The National Academies of Sciences, Engineering and Medicine

Day 1 Presentations -- Tuesday, 27 November 2018

9:00 a.m. Genes, Genomes, and Genetic Variation

Kathryn Song Eng Cheah, The University of Hong Kong [slides available]

John Christodoulou, The University of Melbourne [slides available]
Pak C. Sham, University of Hong Kong [slides available]
Dana Carroll, University of Utah [slides available]

11:00 a.m. Social and Philosophical Reflections on Manipulating Genetic Variation

Kazuto Kato,* Osaka University [slides available]

Renzong Qiu, Chinese Academy of Social Science [slides available]
Mohammed Ghaly, Hamad Bin Khalifa University [slides available]
Maurizio Balistreri, Università degli Studi di Torino [slides available]
Satoshi Kodama, Kyoto University [slides available]
Margaret Sleeboom-Faulkner, University of Sussex [slides available]

2:00 p.m. The Science of Human Genome Editing

Duanqing Pei,* Guangzhou Institutes of Biomedicine and Health [slides available]

Feng Zhang, Broad Institute [slides available]
David R. Liu, Broad Institute 
Angelo Lombardo, San Raffaele University [slides available]
Jennifer Doudna,* University of California, Berkeley [slides available]

4:15 p.m. Update: Governmental Actions and Advisory Opinions Regarding Human Genome Editing

Jennifer Merchant,* Université Panthéon-Assas Paris [slides available]

Xiaomei Zhai,* Chinese Academy of Medical Sciences and Peking Union Medical College [slides available]
Hervé Chneiweiss, Centre National de la Recherche Scientifique, France [slides available]
S.R. Rao, Ministry of Science and Technology, Government of India [slides available]
Hidenori Akutsu, National Research Institute for Child Health and Development [slides available]
Dianne Nicol, University of Tasmania [slides available]
Tamra Maree Lysaght, National University of Singapore [slides available]
Lot Chan, Hong Kong Special Administrative Region [slides available]


Day 2 Presentations -- Wednesday, 28 November 2018

8:35 a.m. Current Research and Clinical Applications: Pathways to Translation

Y.M. Dennis Lo, The Chinese University of Hong Kong

George Q. Daley,* Harvard Medical School [slides available]

9:20 a.m. Blood Disorders – Basic and Translational Research

Beverley Francis-Gibson, Sickle Cell Disease Association of America, Inc. [slides available]

Merlin Crossley, University of New South Wales, Sydney [slides available
Sivaprakash Ramalingam, Institute of Genomics and Integrative Biology [slides available]
Matthew Porteus,* Stanford University [slides available]
Junjiu Huang, Sun Yat-sen University [slides available]
Vence L. Bonham, National Human Genome Research Institute [slides available]

11:30 a.m. Human Embryo Editing

Robin-Lovell-Badge,* The Francis Crick Institute [slides available]

Kathy Niakan, The Francis Crick Institute [slides available]
Paula Amato, Oregon Health & Science University [slides available]
Maria Jasin, Memorial Sloan Kettering Cancer Institute [slides available]
Xingxu Huang, Shanghai Tech University [slides available]
Jiankui He, Southern University of Science and Technology

2:15 p.m. Genome Editing of Heritable Diseases: Technical and Societal Considerations

Richard O. Hynes, Massachusetts Institute of Technology

Adrian Thrasher, University College London [slides available]
R. Rodney Howell, University of Miami [slides available]
Charles A. Gersbach, Duke University [slides available]
Pauline McCormack, Newcastle University [slides available]

4:15 p.m. Human Genome Editing: Research Ethics

R. Alta Charo,* University of Wisconsin, Madison

Bärbel Friedrich, German National Academy of Sciences Leopoldina [slides available]
Andy Greenfield, Medical Research Council [slides available]
Jeffrey Kahn, Johns Hopkins University
Tetsuya Ishii, Hokkaido University [slides available]
Eben Kirksey, Deakin University [slides available]


Day 3 Presentations -- Thursday, 29 November 2018

8:10 a.m. Global Perspectives: Somatic and Germline Therapy, Prevention, and Enhancement Applications

Ayo Wahlberg, University of Copenhagen [slides available]

Kevin G. Behrens, University of the Witwatersrand [slides available]
Guido de Wert, Maastricht University [slides available]
Peter Mills, Nuffield Council on Bioethics [slides available]
Yuko Harayama, Tohoku University [slides available]

9:30 a.m. Identifying Basic Principles for Moving Forward

María de Jesús Medina Arellano, National Autonomous University of Mexico

Sarah Chan, University of Edinburgh [slides available]
Ames Dhai, University of the Witwatersrand [slides available]
J. Benjamin Hurlbut, Arizona State University [slides available]
Ock-Joo Kim, Seoul National University [slides available]

11:30 a.m. Public Engagement Efforts

Jennifer Doudna,* University of California, Berkeley

Anna Middleton, Wellcome Sanger Institute [slides available]
Joy Y. Zhang, University of Kent [slides available]
Megan Munsie, University of Melbourne [slides available]
Masako Takuma, National Museum of Emerging Science and Innovation [slides available]


Breakout Sessions -- Thursday, 29 November 29 2018

I. Embryo and Germline Editing: A Forward Look at Research, Application, and Governance, 2:15 p.m. - 4:45 p.m.

Session Co-chairs:
Robin Lovell Badge,* The Francis Crick Institute
Duanqing Pei,* Guangzhou Institutes of Biomedicine and Health

2:15 p.m. - 3:00 p.m. Panel 1 

Maria Jasin, Sloan Kettering Institute – Trust in Science, Scientists and the Role of Journals [slides available]
Kathy Niakan, The Francis Crick Institute – The Unknowns of Early Human Development and the Impact on Genome Editing [slides available]
Xingxu Huang, ShanghaiTech University – To Develop Base-Editing Platforms for Correction of Pathogenic Mutations in Human Embryos [slides available]

3:15 p.m. - 4:00 p.m. Panel 2 

Helen O’Neill, University College London – Forging a Bench to Clinical Pipeline in Human Germline Editing [slides available]
Judith Daar, University of California, Irvine School of Law – The Ethics of Germline Genome Editing: The Role of Consent Among the Unavailable and Unborn [slides available]

II. Let’s Talk About Genomics and Genome Editing, 6:30 p.m. - 9:30 p.m.

6:55 p.m. Introduction to Human Genomics

Clara Tang, The University of Hong Kong [slides available]

7:20 p.m. Introduction to Genome Editing

Robin Lovell-Badge,* The Francis Crick Institute [slides available]

8:00 p.m. Public Engagement on Biosciences in China

Joy Zhang, University of Kent [slides available]

8:20 p.m. Public Engagement on Human Genome Editing in the UK

Sarah Chan, The University of Edinburgh

*Member of Summit Organizing Committee