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Current State of Research, Development, and Stockpiling of Smallpox Medical Countermeasures

Completed

An ad hoc committee of the National Academies of Sciences, Engineering, and Medicine will conduct a study to examine lessons learned from the recent Coronavirus Disease 2019 (COVID-19) pandemic and mpox multi-country outbreak to inform an evaluation of the current state of research, development, and stockpiling of smallpox medical countermeasures (MCMs).

Description

An ad hoc committee of the National Academies of Sciences, Engineering, and Medicine will conduct a study to examine lessons learned from the recent Coronavirus Disease 2019 (COVID-19) pandemic and mpox multi-country outbreak to inform an evaluation of the current state of research, development, and stockpiling of smallpox medical countermeasures (MCMs). The committee will:

  1. Consider how the COVID-19 pandemic and the mpox multi-country outbreak can inform improvements to smallpox readiness and response, including the availability of smallpox MCMs and the ability to meet potential demand.
  2. Examine the current state of MCMs for the diagnosis, prevention, and treatment of smallpox, including: a.) How the mpox outbreak altered assumptions about the efficacy and utility of smallpox MCMs, b.) The continued role of live Variola virus for research and public health purposes, and c.) Implications for the composition of smallpox MCMs in the U.S. Strategic National Stockpile (SNS).
  3. Explore the benefits and risks of scientific and technological advances on smallpox readiness and response and identify key priorities in research and development of smallpox MCMs.

Building on the Institute of Medicine's previous reports, Assessment of Future Scientific Needs for Live Variola Virus (1999) and Live Variola Virus: Considerations for Continuing Research (2009), and a review of existing literature, analyses, and other expert and public input, the committee will develop a report with its findings and conclusions on priorities for additional research or activities to improve the U.S. Government readiness and response posture against smallpox, and on the composition of the SNS to ensure appropriate smallpox MCM response options.

Contributors

Committee

Chair

Member

Member

Member

Member

Member

Member

Member

Member

Member

Member

Member

Member

Member

Sponsors

Administration for Strategic Preparedness and Response

Staff

Lisa Brown

Lead

Shalini Singaravelu

Matthew Masiello

Margaret McCarthy

Rayane Silva-Curran

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