An ad hoc committee of The National Academies of Sciences, Engineering, and Medicine will be convened to develop a framework for scanning the peer-reviewed published literature on riboflavin that is based on the generic analytic framework for Dietary Reference Intakes (DRIs) to assess the relation of nutrient intake to health outcomes. The committee will build on the methodology for evidence scanning of nutrients (which have exiting DRIs) to further determine whether there is new and relevant knowledge available that may merit a formal reexamination of DRIs for this nutrient. The committee will carry out a literature search and evidence scan of the peer-reviewed published literature on indicators of nutritional requirements, toxicity, and chronic disease risk reduction for riboflavin. To carry out the scan the committee will review, interpret, and apply as needed the current DRI framework and evidence scanning methodology for riboflavin. The committee will develop pre-specified criteria; identify health outcome indicators related to riboflavin including, as appropriate, indicators of physiological requirement, toxicity, and chronic disease risk, and assess the evidence for dose-response or other relevant relationships between health outcome(s) and dietary intake. A one-half day web-based open meeting will be convened with subject matter experts in a discussion of relevant issues. The final product will include a brief summary of the methodology used to conduct the evidence scan, a table of the reviewed studies, and the committee's assessment of the tabulated evidence. The final product will serve as a template for use in informing development of future DRI values. The committee's final product will be reviewed in accordance with institutional requirements.