U.S. land-grant colleges and universities were established nationwide to develop and apply knowledge for public benefit. The impact of their work could be more readily recognized by the public if they worked collaboratively with each other and with external partners, including nonland-grant institutions and the private sector. A workshop-based consensus study will identify the essential ingredients of collaborative platforms that support high-quality science, education, and extension across all institutions in the land-grant system along with non-land grant partners.