| AFB | Air Force Base |
| AFDX | Avionics Full-Duplex Switched Ethernet |
| AFLCMC | Air Force Life Cycle Management Center |
| AFMC | Air Force Materiel Command |
| AFRL | Air Force Research Laboratory |
| AFSB | Air Force Studies Board |
| AI | artificial intelligence |
| ALC | Air Logistics Complex |
| API | application program interface |
| ASIC | application-specific integrated circuit |
| ATO | Authorization to Operate |
| COTS | commercial-off-the-shelf |
| CS | computer science |
| DCGS | Distributed Common Ground System |
| DevOps | Development and Operations |
| DevSecOps | Development, Security, and Operations |
| DIB | Defense Innovation Board |
| DoD | Department of Defense |
| DSB | Defense Science Board |
| ECP | Engineering Change Proposal |
| FY | fiscal year |
| GAO | Government Accountability Office |
| GBSD | Ground Based Strategic Deterrent |
| GPS | Global Positioning System |
| IP | intellectual property |
| ISR | Intelligence, Surveillance, and Reconnaissance |
| IT | information technology |
| JFAC | Joint Federated Assurance Center |
| JPO | Joint Program Office |
| LRU | line replaceable unit |
| ML | machine learning |
| MS A | Milestone A |
| MS C | Milestone C |
| MVP | Minimum Viable Product |
| OEM | original equipment manufacturer |
| OFP | Operational Flight Program |
| OODA | Observe, Orient, Decide, Act |
| OSD | Office of the Secretary of Defense |
| OT | Operational Test |
| PEO | Program Executive Officer |
| PRC2 | Personnel Recovery Command and Control |
| R&D | research and development |
| SA | software assurance |
| SAF/AQ | Assistant Secretary of the Air Force for Acquisition Technology and Logistics |
| SAP | Special Access Program |
| SCIF | Sensitive Compartmented Information Facility |
| SEI | Software Engineering Institute |
| SIL | System Integration Laboratory |
| SLOC | source lines of code |
| SMXG | Software Maintenance Group |
| SPO | System Program Office |
| S&T | science and technology |
| SWEG | Software Engineering Group |
| UAV | unmanned aerial vehicle |
| USAF | U.S. Air Force |
| WBS | work breakdown structure |
| ZAP | ZED Attack Proxy |