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Compounded topical pain creams have gained popularity among some prescribers and patients, as they are marketed as having fewer side effects, lower likelihood for abuse, and the potential for greater efficacy and convenience than certain oral pain medications. Importantly, the FDA does not review or approve the safety and effectiveness of compounded preparations. Many ingredients used in compounded topical pain creams are not FDA-approved to treat pain, and many contain multiple active ingredients, prompting the FDA to ask the National Academies to convene a consensus study to evaluate the safety and effectiveness of the ingredients used in these compounded preparations.
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