Promoting Chemical Laboratory Safety and Security in Developing Countries (2010)
Chapter: Appendix D: Examples of Chemicals of Concern
D
Examples of Chemicals of Concern
The following Tables (D-1 through D-5) are examples of the types of chemicals that a laboratory would include in an inventory of Chemicals of Concern (COCs).
TABLE D-1 Chemical Weapons and Chemical Weapons Precursorsa:
|
Chemical of Concern |
Synonym |
CAS Registry Numberb |
|
1,4-Bis(2-chloroethylthio)-n-butane |
|
142868-93-7 |
|
Bis(2-chloroethylthio)methane |
|
63869-13-6 |
|
Bis(2-chloroethylthiomethyl)ether |
|
63918-90-1 |
|
1,5-Bis(2-chloroethylthio)-n-pentane |
|
142868-94-8 |
|
1,3-Bis(2-chloroethylthio)-n-propane |
|
63905-10-2 |
|
2-Chloroethylchloro-methylsulfide |
|
2625-76-5 |
|
Chlorosarin |
O-Isopropyl methylphosphonochloridate |
1445-76-7 |
|
Chlorosoman |
O-Pinacolyl methylphosphonochloridate |
7040-57-5 |
|
Chemical of Concern |
Synonym |
CAS Registry Numberb |
|
DF |
Methyl phosphonyl difluoride |
676-99-3 |
|
Ethyl phosphonyl difluoride |
|
753-98-0 |
|
HN1 (nitrogen mustard-1) |
Bis(2-chloroethyl)ethylamine |
538-07-8 |
|
HN2 (nitrogen mustard-2) |
Bis(2-chloroethyl)methylamine |
51-75-2 |
|
HN3 (nitrogen mustard-3) |
Tris(2-chloroethyl)amine |
555-77-1 |
|
Isopropylphosphonyl difluoride |
|
677-42-9 |
|
Lewisite 1 |
2-Chlorovinyldichloroarsine |
541-25-3 |
|
Lewisite 2 |
Bis(2-chlorovinyl)chloroarsine |
40334-69-8 |
|
Lewisite 3 |
Tris(2-chlorovinyl)arsine |
40334-70-1 |
|
Sulfur mustard (mustard gas (H)) |
Bis(2-chloroethyl)sulfide |
505-60-2 |
|
O-Mustard (T) |
Bis(2-chloroethylthioethyl)ether |
63918-89-8 |
|
Propylphosphonyl difluoride |
|
690-14-2 |
|
QL |
O-Ethyl-O-2-diisopropylaminoethyl methylphosphonite |
57856-11-8 |
|
Sarin |
O-Isopropyl methylphosphonofluoridate |
107-44-8 |
|
Sesquimustard |
1,2-Bis(2-chloroethylthio)ethane |
3563-36-8 |
|
Soman |
O-Pinacolyl methylphosphonofluoridate |
96-64-0 |
|
Tabun |
O-Ethyl-N,N-dimethylphosphoramido-cyanidate |
77-81-6 |
|
VX |
O-Ethyl-S-2-diisopropylaminoethyl methyl phosphonothiolate |
50782-69-9 |
|
NOTE: Toxic chemicals with few or no legitimate uses, developed or used primarily for military purposes. aU.S. Chemical Weapons Convention Schedule 1; see http://www.cwc.gov/ (accessed October 28, 2009). bSee Chemical Abstract Service web site www.cas.org (accessed October 28, 2009). SOURCE: U.S. Department of Homeland Security list of Chemicals of Interest (6 CFR Part 27 Appendix to Chemical Facility Anti-Terrorism Standards; Final Rule; November 20, 2007). |
||
TABLE D-2 Explosives and Improvised Explosive Device Precursors
|
Chemical of Concern |
Synonym |
CAS Registry Number |
|
Aluminum (powder) |
|
7429-90-5 |
|
Ammonium nitrate |
|
6484-52-2 |
|
Ammonium perchlorate |
|
7790-98-9 |
|
Ammonium picrate |
|
131-74-8 |
|
Barium azide |
|
18810-58-7 |
|
Diazodinitrophenol |
|
87-31-0 |
|
Diethyleneglycol dinitrate |
|
693-21-0 |
|
Dingu |
Dinitroglycoluril |
55510-04-8 |
|
Dinitrophenol |
|
25550-58-7 |
|
Dinitroresorcinol |
|
519-44-8 |
|
Dipicryl sulfide |
|
2217-06-3 |
|
Dipicrylamine [or] Hexyl |
Hexanitrodiphenylamine |
131-73-7 |
|
Guanyl nitrosaminoguanylidene hydrazine |
|
|
|
Hexanitrostilbene |
|
20062-22-0 |
|
Hexolite |
Hexotol |
121-82-4 |
|
HMX |
Cyclotetramethylene-tetranitramine |
2691-41-0 |
|
Hydrogen peroxide (concentration of at least 35%) |
|
7722-84-1 |
|
Lead azide |
|
13424-46-9 |
|
Lead styphnate |
Lead trinitroresorcinate |
15245-44-0 |
|
Magnesium (powder) |
|
7439-95-4 |
|
Mercury fulminate |
|
628-86-4 |
|
Nitrobenzene |
|
98-95-3 |
|
5-Nitrobenzotriazol |
|
2338-12-7 |
|
Nitrocellulose (not filters) |
|
9004-70-0 |
|
Nitroglycerine |
|
55-63-0 |
|
Nitromannite |
Mannitol hexanitrate, wetted |
15825-70-4 |
|
Nitromethane |
|
75-52-5 |
|
Nitrostarch |
|
9056-38-6 |
|
Nitrotriazolone |
|
932-64-9 |
|
Octolite |
|
57607-37-1 |
|
Octonal |
|
78413-87-3 |
|
Pentolite |
|
8066-33-9 |
|
PETN |
Pentaerythritol tetranitrate |
78-11-5 |
|
Chemical of Concern |
Synonym |
CAS Registry Number |
|
Phosphorus |
|
7723-14-0 |
|
Potassium chlorate |
|
3811-04-9 |
|
Potassium nitrate |
|
7757-79-1 |
|
Potassium perchlorate |
|
7778-74-7 |
|
Potassium permanganate |
|
7722-64-7 |
|
RDX |
Cyclotrimethylenetrinitramine |
121-82-4 |
|
RDX and HMX mixtures |
|
121-82-4 |
|
Sodium azide |
|
26628-22-8 |
|
Sodium chlorate |
|
7775-09-9 |
|
Sodium nitrate |
|
7631-99-4 |
|
Tetranitroaniline |
|
53014-37-2 |
|
Tetrazene |
Guanyl nitrosaminoguanyltetrazene |
109-27-3 |
|
1H-Tetrazole |
|
288-94-8 |
|
TNT |
Trinitrotoluene |
118-96-7 |
|
Torpex |
Hexotonal |
67713-16-0 |
|
Trinitroaniline |
|
26952-42-1 |
|
Trinitroanisole |
|
606-35-9 |
|
Trinitrobenzene |
|
99-35-4 |
|
Trinitrobenzenesulfonic acid |
|
2508-19-2 |
|
Trinitrobenzoic acid |
|
129-66-8 |
|
Trinitrochlorobenzene |
|
88-88-0 |
|
Trinitrofluorenone |
|
129-79-3 |
|
Trinitro-m-cresol |
|
602-99-3 |
|
Trinitronaphthalene |
|
55810-17-8 |
|
Trinitrophenetole |
|
4732-14-3 |
|
Trinitrophenol |
Picric acid |
88-89-1 |
|
Trinitroresorcinol |
|
82-71-3 |
|
Tritonal |
|
54413-15-9 |
|
SOURCE: U.S. Department of Homeland Security list of Chemicals of Interest (6 CFR Part 27 Appendix to Chemical Facility Anti-Terrorism Standards; Final Rule; November 20, 2007). |
||
TABLE D-3 Weapons of Mass Effect Agents and Precursors
|
Chemical of Concern |
Synonym |
CAS Registry Number |
|
Arsine |
|
7784-42-1 |
|
Boron tribromide |
|
10294-33-4 |
|
Boron trichloride |
Borane, trichloro |
10294-34-5 |
|
Boron trifluoride |
Borane, trifluoro |
7637-07-2 |
|
Bromine chloride |
|
13863-41-7 |
|
Bromine trifluoride |
|
7787-71-5 |
|
Dinitrophenol |
|
25550-58-7 |
|
Dinitroresorcinol |
|
519-44-8 |
|
Carbonyl fluoride |
|
353-50-4 |
|
Chlorine pentafluoride |
|
13637-63-3 |
|
Chlorine trifluoride |
|
7790-91-2 |
|
Cyanogen |
Ethanedinitrile |
460-19-5 |
|
Cyanogen chloride |
|
506-77-4 |
|
Diborane |
|
19287-45-7 |
|
Dichlorosilane |
Silane, dichloro- |
4109-96-0 |
|
Dinitrogen tetroxide |
|
10544-72-6 |
|
Fluorine |
|
7782-41-4 |
|
Germane |
|
7782-65-2 |
|
Germanium tetrafluoride |
|
7783-58-6 |
|
Hexafluoroacetone |
|
684-16-2 |
|
Hydrogen bromide (anhydrous) |
|
10035-10-6 |
|
Hydrogen chloride (anhydrous) |
|
7647-01-0 |
|
Hydrogen cyanide |
Hydrocyanic acid |
74-90-8 |
|
Hydrogen fluoride (anhydrous) |
|
7664-39-3 |
|
Hydrogen iodide, anhydrous |
|
10034-85-2 |
|
Hydrogen selenide |
|
7783-07-5 |
|
Hydrogen sulfide |
|
7783-06-4 |
|
Methyl mercaptan |
Methanethiol |
74-93-1 |
|
Methylchlorosilane |
|
993-00-0 |
|
Nitric oxide |
Nitrogen oxide (NO) |
10102-43-9 |
|
Nitrogen trioxide |
|
10544-73-7 |
|
Nitrosyl chloride |
|
2696-92-6 |
|
Oxygen difluoride |
|
7783-41-7 |
|
Perchloryl fluoride |
|
7616-94-6 |
|
Chemical of Concern |
Synonym |
CAS Registry Number |
|
Phosgene |
Carbonic dichloride or carbonyldichloride |
75-44-5 |
|
Phosphine |
|
7803-51-2 |
|
Phosphorus trichloride |
|
7719-12-2 |
|
Selenium hexafluoride |
|
7783-79-1 |
|
Silicon tetrafluoride |
|
7783-61-1 |
|
Stibine |
|
7803-52-3 |
|
Sulfur dioxide (anhydrous) |
|
7446-09-5 |
|
Sulfur tetrafluoride |
Sulfur fluoride (SF4), (T-4)- |
7783-60-0 |
|
Tellurium hexafluoride |
|
7783-80-4 |
|
Titanium tetrachloride |
Titanium chloride (TiCl4) (T-4)- |
7550-45-0 |
|
Trifluoroacetyl chloride |
|
354-32-5 |
|
Tungsten hexafluoride |
|
7783-82-6 |
|
SOURCE: U.S. Department of Homeland Security list of Chemicals of Interest (6 CFR Part 27 Appendix to Chemical Facility Anti-Terrorism Standards; Final Rule; November 20, 2007). |
||
TABLE D-4 Examples of Acutely Hazardous Chemicals (Globally Harmonized System Category 1)
|
Chemical of Concern |
Synonym |
CAS Registry Number |
|
Acrolein |
2-Propenal or acrylaldehyde |
107-02-8 |
|
2-Aminopyridine |
|
462-08-8 |
|
Arsenic pentafluoride gas |
|
784-36-3 |
|
Arsine gas |
|
7784-42-1 |
|
Benzyl chloride |
|
100-44-7 |
|
Boron trifluoride |
Borane, trifluoro |
7637-07-2 |
|
Bromine |
|
7726-95-6 |
|
Chlorine |
|
7782-50-5 |
|
Chorine dioxide |
Chlorine oxide (ClO2) |
10049-04-4 |
|
Chlorine trifluoride |
|
7790-91-2 |
|
Cyanogen chloride |
|
506-77-4 |
|
Decaborane |
|
17702-41-9 |
|
Diazomethane |
|
334-88-3 |
|
Diborane |
|
19287-45-7 |
|
Dichloroacetylene |
|
79-36-7 |
|
Dimethylmercury |
|
593-74-8 |
|
Dimethyl sulfate |
|
77-78-1 |
|
Dimethyl sulfide |
|
75-18-3 |
|
Ethylene chlorohydrin |
|
107-07-3 |
|
Ethylene fluorohydrin |
|
371-62-0 |
|
Fluorine |
|
7681-49-4 |
|
2-Fluoroethanol |
|
371-62-0 |
|
Hexamethylene diiosocyanate |
|
822-06-0 |
|
Hydrogen cyanide |
Hydrocyanic acid |
74-90-8 |
|
Hydrogen fluoride |
|
7664-39-3 |
|
Iron pentacarbonyl |
Iron carbonyl (Fe (CO)5), (Tb5-11)- |
13463-40-6 |
|
Isopropyl formate |
|
625-55-8 |
|
Methacryloyl chloride |
|
920-46-7 |
|
Methyl acrylonitrile |
2-Propenenitrile, 2-methyl- |
126-98-7 |
|
Methyl chloroformate |
Carbonochloridic acid, methyl ester |
79-22-1 |
|
Methylene biphenyl isocyanate |
|
101-68-9 |
|
Methyl fluoroacetate |
|
453-18-9 |
|
Methyl fluorosulfate |
|
421-20-5 |
|
Methyl hydrazine |
Hydrazine, methyl- |
60-34-4 |
|
Chemical of Concern |
Synonym |
CAS Registry Number |
|
Methyl mercury and other organic forms |
|
--- |
|
Methyl trichlorosilane |
|
75-79-6 |
|
Methyl vinyl ketone |
|
78-94-4 |
|
Nickel carbonyl |
|
13463-39-3 |
|
Nitrogen dioxide |
|
10102-44-0 |
|
Nitrogen tetroxide |
|
10544-72-6 |
|
Nitrogen trioxide |
|
10544-73-7 |
|
Osmium tetroxide |
|
20816-12-0 |
|
Oxygen difluoride |
|
7783-41-7 |
|
Pentaborane |
|
19624-22-7 |
|
Perchloromethlyl mercaptan |
Methanesulfenyl chloride, trichloro- |
594-42-3 |
|
Phosgene |
Carbonic dichloride or carbonyl dichloride |
75-45-5 |
|
Phosphine |
|
1498-40-4 |
|
Phosphorus oxychloride |
Phosphoryl chloride |
10025-87-3 |
|
Phosphorus pentafluoride |
|
7641-19-0 |
|
Phosphorus trichloride |
|
7719-12-2 |
|
Sarin |
O-Isopropyl methylphosphonofluoridate |
107-44-8 |
|
Selenium hexafluoride |
|
7783-79-1 |
|
Silicon tetrafluoride |
|
7783-61-1 |
|
Sodium azide |
|
26628-22-8 |
|
Sodium cyanide (and other cyanide salts) |
|
143-33-9 |
|
Stibine |
|
10025-91-9 |
|
Sulfur monochloride |
|
10025-67-9 |
|
Sulfur pentafluoride |
|
10546-01-7 |
|
Sulfur tetrafluoride |
Sulfur fluoride (SF4), (T-4)- |
7783-60-0 |
|
Sulfuryl chloride |
|
7791-25-5 |
|
Tellurium hexafluoride |
|
7783-80-4 |
|
Tetramethyl succinonitrile |
|
3333-52-6 |
|
Tetranitromethane |
Methane, tetranitro- |
509-14-8 |
|
Thionyl chloride |
|
7719-09-7 |
|
Toluene-2,4-diisocyanate |
|
584-84-9 |
|
Trichloro(chlormethyl)silane |
|
1558-25-4 |
|
Trimethyltin chloride |
|
1066-45-1 |
|
SOURCE: U.S. Department of Homeland Security list of Chemicals of Interest (6 CFR Part 27 Appendix to Chemical Facility Anti-Terrorism Standards; Final Rule; November 20, 2007). |
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TABLE D-5 Chemicals Used in Clandestine Production of Illicit Drugs
|
Chemical of Concern |
Target Product |
|
Acetic acid |
Phenyl-2-propanone (P-2-P)/cocaine |
|
Acetic anhydride |
Heroin/P-2-P/methaqualone |
|
Acetone |
Cocaine/heroin/others |
|
Acetyl chloride |
Heroin |
|
N-Acetylanthranilic acid |
Methaqualone |
|
Ammonium formate |
Amphetamines |
|
Ammonium hydroxide |
Cocaine/others |
|
Anthranilic acid |
Methaqualone |
|
Benzaldehyde |
Amphetamines |
|
Benzene |
Cocaine |
|
Benzyl chloride |
Methamphetamine |
|
Benzyl cyanide |
Methamphetamine |
|
2-Butanone (methyl ethyl ketone) |
Cocaine |
|
Butyl acetate |
Cocaine |
|
N-Butyl alcohol |
Cocaine |
|
Calcium carbonate |
Cocaine/others |
|
Calcium oxide/hydroxide |
Cocaine/others |
|
Chloroform |
Cocaine/others |
|
Cyclohexanone |
Phencyclidine (PCP) |
|
Diacetone alcohol |
Cocaine |
|
Diethylamine |
Lysergic acid diethylamide (LSD) |
|
Ephedrine |
Methamphetamine |
|
Ergometrine (ergonovine) |
LSD |
|
Ergotamine |
LSD |
|
Ethyl acetate |
Cocaine |
|
Ethyl alcohol |
Cocaine/others |
|
Ethyl amine |
Ethy lamphetamine/3,4-methylenedioxy-N-ethylamphetamine (MDE) |
|
Ethyl ether |
Cocaine/heroin/others |
|
N-Ethy1ephedrine |
Ethylamphetamine/MDE |
|
N-Ethylpseudoephedrine |
Amphetamines |
|
Formamide |
Cocaine |
|
Hexane |
Methamphetamine |
|
Hydriodic (hydriotic) acid |
Cocaine/heroin/others |
|
Hydrochloric acid |
Cocaine |
|
Isopropyl alcohol |
Cocaine |
|
Isosafrole |
Cocaine |
|
Kerosene |
LSD |
|
Lysergic acid |
Cocaine |
|
Methyl alcohol |
Methamphetamine/3,4- |
|
Methylamine |
methylenedioxymethamphetamine (MDMA) |
|
Methylene chloride |
Cocaine/heroin/others |
|
3,4-Methylenedioxyphenyl- |
3,4-MethyIenedioxyamphetamine |
|
2-propanone |
(MDA)/MDMA/MDE |
|
N-Methylephedrine |
Amphetamines |
|
N-Methylpseudoephedrine |
Amphetamines |
|
Chemical of Concern |
Target Product |
|
Nitroethane |
Amphetamines |
|
Norpseudoephedrine |
4-Methylaminorex |
|
Petroleum ether |
Cocaine/others |
|
Phenylacetic acid |
Phenyl-2-propanone |
|
Phenylpropanolamine |
Amphetamines/4-methylaminorex |
|
1-Phenyl-2-propanone |
Amphetamines/methamphetamine |
|
Piperidine |
PCP |
|
Piperonal |
MDA/MDMA/MDE |
|
Potassium carbonate |
Cocaine |
|
Potassium permanganate |
Cocaine |
|
Propionic anhydride |
Fentanyl analogues |
|
Pseudoephedrine |
Methamphetamine |
|
Pyridine |
Heroin |
|
Safrole |
MDA/MDMA/MDE |
|
Sodium acetate |
P-2-P |
|
Sodium bicarbonate |
Cocaine/others |
|
Sodium carbonate |
Cocaine/others |
|
Sodium cyanide |
PCP |
|
Sodium hydroxide |
Cocaine/others |
|
Sodium suifate |
Cocaine/others |
|
Sulfuric acid |
Cocaine/others |
|
Toluene |
Cocaine |
|
o-Toluidine |
Methaqualone |
|
Xylenes |
Cocaine |
|
NOTE: Organizations may opt not to treat the commonly used chemicals on this list as COCs (e.g., acetone). SOURCE: Severick, James. 1993. Precursor and Essential Chemicals in Illicit Drug Production: Approaches to Enforcement, National Institute of Justice. http://www.popcenter.org/problems/meth_labs/PDFs/Sevick_1993.pdf (accessed July 2009). |
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