Glutamate-related Biomarkers in Drug Development for Disorders of the Nervous System

Workshop

Glutamate-related Biomarkers in Drug Development for Disorders of the Nervous System – A Workshop

June 21 - 22, 2010

Past

About

Meeting objectives:

Briefly outline the need for glutamate-related biomarkers both for understanding the causes of neuropsychiatric disorders and neurodegenerative diseases associated with glutamatergic dysfunction, and for accelerating drug development for these disorders.
Discuss the most promising current and emerging technologies and analytical methods for assessing glutamatergic neurotransmission, and identify the research gaps for their development into biomarkers.
Outline approaches for biomarker validation in preclinical and clinical studies, including relevant animal models and translational challenges.
Discuss the implementation and regulatory barriers to incorporating glutamatergic biomarkers into drug development for neuropsychiatric disorders and neurodegenerative diseases and approaches to overcome them.
Identify the next steps to establish principles and procedures to accelerate biomarker development, validation, and implementation in clinical trials, including frameworks for partnerships andcollaboration.

Contact

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(202) 334-3265
neuroforum@nas.edu

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Glutamate-related Biomarkers in Drug Development for Disorders of the Nervous System – A Workshop

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Glutamate-related Biomarkers in Drug Development for Disorders of the Nervous System – A Workshop