Previous Chapter: Appendix G Executive Summary and Recommendations of the DoD Report Acquisition of Vaccine Production
Suggested Citation: "Appendix H Open Meeting Agenda." Institute of Medicine. 2006. Battling Malaria: Strengthening the U.S. Military Malaria Vaccine Program. Washington, DC: The National Academies Press. doi: 10.17226/11656.

Appendix H
Open Meeting Agenda

COMMITTEE ON DOD’S MALARIA VACCINE RESEARCH—A PROGRAM REVIEW

January 23–25, 2006

Courtyard by Marriott

8506 Fenton St.

Silver Spring, MD 20910

Tel 301-589-4899

Meeting Room

AGENDA

Meeting Objectives

  • Obtain perspectives from DoD on the malaria threat to the force

  • Review DoD’s P. falciparum malaria vaccine research program

  • Review nonmilitary malaria vaccine efforts

  • Develop initial findings and recommendations regarding DoD’s Program

Suggested Citation: "Appendix H Open Meeting Agenda." Institute of Medicine. 2006. Battling Malaria: Strengthening the U.S. Military Malaria Vaccine Program. Washington, DC: The National Academies Press. doi: 10.17226/11656.

Monday, January 23, 2006

Closed Session

8:00

Bias and Conflict Discussion

Susanne Stoiber

Executive Director, Institute of Medicine

Open Session

9:00

MIDRP Welcome

COL David Vaughn, MC

Director, Military Infectious Disease Research Program

Fort Detrick, Maryland

9:15

Chairman’s Remarks and Introductions

9:30

MIDRP and Malaria Program Overview and Review of Committee Charge

COL David Vaughn

10:30

Break

11:00

Overview Malaria Vaccine Development

Dr. Filip Dubovsky

Scientific Director, Malaria Vaccine Initiative

12:00

Lunch

1:00–5:15

Program Review—Protein-based vaccine strategy

1:00

Objectives and Strategy

COL Gray Heppner

1:30

Progress towards an RTS,S-Based Vaccine by Year 2010: New Adjuvants, Antigens, and Vectors

  • Status of RTS,S/AS02A

COL Gray Heppner

  • Adjuvant AS01B: RTS,S/AS02A vs. RTS,S/AS01B

COL Kent Kester

  • GMP Pf Antigens MSP-1, AMA-1, and LSA-1

Dr. Evelina Angov

  • Adenovirus 35 with circumsporozoite protein

Dr. Ann Stewart

Suggested Citation: "Appendix H Open Meeting Agenda." Institute of Medicine. 2006. Battling Malaria: Strengthening the U.S. Military Malaria Vaccine Program. Washington, DC: The National Academies Press. doi: 10.17226/11656.

2:50

Break

3:00

Clinical Trials of an RTS,S-Based Vaccine

COL Gray Heppner

3:30

Future Vaccines

  • Antigen Discovery

COL Chris Ockenhouse

  • Vivax

COL Chris Ockenhouse

  • Attenuated Knock-out

COL Gray Heppner

4:00

Building the RTS,S-Based Vaccine

  • One Allele or Two?

COL Chris Ockenhouse

  • The role of molecular analyses

  • Making Development Earlier

COL Chris Ockenhouse

  • The potential microarrays

  • Assays of Immune Response

Dr. Ann Stewart

  • From robust to validated

4: 30

Barriers from Proof of Concept to Licensure

COL Gray Heppner

  • Funding

  • Industrial Partners

  • Licensure Trials

5:00

Discussion

6:30–8:30

Committee Dinner at Redrock Canyon Restaurant, Silver Spring, Maryland

Suggested Citation: "Appendix H Open Meeting Agenda." Institute of Medicine. 2006. Battling Malaria: Strengthening the U.S. Military Malaria Vaccine Program. Washington, DC: The National Academies Press. doi: 10.17226/11656.

Tuesday, January 24, 2006

Open Session

8:00–12:30

Program Review—DNA-based vaccine strategy

8:00

Objective, Background & Rationale

CAPT Tom Richie

8:30

Program History

CAPT Tom Richie

8:50

Functional Elements & Activities

  • Overview

CAPT Tom Richie

  • Discovery Research

Dr. Denise Doolan

  • Target Antigens

  • Immune Mechanism

9:50

Break (30 minutes)

  • Preclinical Research

Dr. Denise Doolan

  • Preclinical Development

Dr. Denise Doolan

  • Regulatory Affairs

Ms. Gail Levine

  • Clinical Trials

LCDR David Regis

11:05

Clinical Development Plan

CAPT Tom Richie

11:30

Barriers to Progress

CAPT Tom Richie

12:00

Attenuated Sporozoite Vaccine

CAPT Tom Richie

12:30

Lunch

Closed Executive Session

1:30

Discussion of the DoD program including review of questions posed by the sponsor about the Vaccine Program

5:30–5:45

Chairman’s time

6:30–8:30

Dinner at hotel, local restaurant of choice OR evening working session

Suggested Citation: "Appendix H Open Meeting Agenda." Institute of Medicine. 2006. Battling Malaria: Strengthening the U.S. Military Malaria Vaccine Program. Washington, DC: The National Academies Press. doi: 10.17226/11656.

Wednesday, January 25, 2006

Closed Executive Session*

8:00–12:00

Structured discussion of the DoD malaria vaccine research program

  • Clarify gaps or missing information

  • Finish discussions regarding key program questions

  • Develop initial findings and recommendations

  • Establish second meeting date to review report draft.

* An open portion of this meeting was posted from 9:00–9:45 and will be honored if needed.

Suggested Citation: "Appendix H Open Meeting Agenda." Institute of Medicine. 2006. Battling Malaria: Strengthening the U.S. Military Malaria Vaccine Program. Washington, DC: The National Academies Press. doi: 10.17226/11656.
Page 110
Suggested Citation: "Appendix H Open Meeting Agenda." Institute of Medicine. 2006. Battling Malaria: Strengthening the U.S. Military Malaria Vaccine Program. Washington, DC: The National Academies Press. doi: 10.17226/11656.
Page 111
Suggested Citation: "Appendix H Open Meeting Agenda." Institute of Medicine. 2006. Battling Malaria: Strengthening the U.S. Military Malaria Vaccine Program. Washington, DC: The National Academies Press. doi: 10.17226/11656.
Page 112
Suggested Citation: "Appendix H Open Meeting Agenda." Institute of Medicine. 2006. Battling Malaria: Strengthening the U.S. Military Malaria Vaccine Program. Washington, DC: The National Academies Press. doi: 10.17226/11656.
Page 113
Suggested Citation: "Appendix H Open Meeting Agenda." Institute of Medicine. 2006. Battling Malaria: Strengthening the U.S. Military Malaria Vaccine Program. Washington, DC: The National Academies Press. doi: 10.17226/11656.
Page 114
Next Chapter: Appendix I Committee and Staff Biographies
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