| AEC | Atomic Energy Commission |
| ASC | Advanced Simulation and Computing |
| CBET | cross-beam energy transfer |
| CH | carbon-hydrogen (plastic used as an ablator) |
| CTBT | Comprehensive Nuclear Test Ban Treaty |
| DCA | Detailed Configuration Analysis |
| DD | direct drive |
| DOE | U.S. Department of Energy |
| DPSSL | diode-pumped, solid-state laser |
| DT | deuterium-tritium |
| EP | extended performance |
| EU | European Union |
| FCT | flux-corrected transport |
| FES | Fusion Energy Sciences |
| FI | fast ignition |
| FIRE | Fast Ignition Realization Experiment |
| HAPL | High Average Power Laser (Program) |
| HDC | high-density carbon |
| HIF | heavy-ion fusion |
| HiPER | High Power Laser Energy Research (facility) |
| IAEA | International Atomic Energy Agency |
| ICF | inertial confinement fusion |
| ID | indirect drive |
| IFE | inertial fusion energy |
| ILE | Institute of Laser Engineering (Japan) |
| IR | infrared |
| ISI | induced spatial incoherence |
| LANL | Los Alamos National Laboratory |
| LBNL | Lawrence Berkeley National Laboratory |
| LEH | laser entrance hole |
| LIFE | Laser Inertial Fusion Energy |
| LLE | Laboratory for Laser Energetics |
| LLNL | Lawrence Livermore National Laboratory |
| LMJ | Laser Megajoule Facility (France) |
| LPI | laser-plasma interactions |
| LTE | local thermal equilibrium |
| MagLIF | magnetized liner inertial fusion |
| MAGO | Explosively Driven Magnetic Implosion (Russia) |
| MCF | magnetic confinement fusion |
| MTF | magnetized target fusion |
| NAS | National Academy of Sciences |
| NIC | National Ignition Campaign |
| NIF | National Ignition Facility |
| NNSA | National Nuclear Security Administration |
| NPT | Nonproliferation Treaty |
| NRC | National Research Council |
| NRL | Naval Research Laboratory |
| ORNL | Oak Ridge National Laboratory |
| PD | polar drive |
| PEP | project execution plan |
| RTL | recyclable transmission line |