| 3D | three-dimensional |
| A2SF | advanced all-source fusion |
| AC&CSD | Advanced Computing and Computational Sciences Division |
| AC2T | academic class composite tool |
| ACM | Association for Computing Machinery |
| ADS | advanced distributed simulation |
| AEC | Army Evaluation Center |
| AFM | atomic force microscopy |
| AFOSR | Air Force Office of Scientific Research |
| AFRL | Air Force Research Laboratory |
| AHAAH | auditory hazard assessment algorithm for humans |
| AMRDEC | Aviation and Missile Research, Development and Engineering Center |
| AMSAA | Army Materiel Systems Analysis Activity |
| APS | active protection system |
| ARDEC | Armament Research, Development and Engineering Center |
| ARL | Army Research Laboratory |
| ARLTAB | Army Research Laboratory Technical Assessment Board |
| ARO | Army Research Office |
| ATO | Army technology objective |
| BCI | brain–computer interaction |
| BED | Battlefield Environment Division |
| BND | Ballistics and Nuclear, Biological, and Chemical Division |
| BRAC | base realignment and closure |
| BRL–CAD | Ballistic Research Laboratory–Computer-Aided Design |
| CAD | computer-aided design |
| CASEL | cognitive assessment, simulation, and engineering laboratory |
| CC | capability concept |
| CECOM | Communications-Electronics Command |
| CERDEC | Communications-Electronics Research, Development, and Engineering Center |
| CFD | computational fluid dynamics |
| CIO/G-6 | Office of the Chief Information Officer |
| CISD | Computational and Information Sciences Directorate |
| CMD-P | computer meteorological data profiler |
| CMMI | capability maturity model integration |
| COTS | commercial off-the-shelf |
| CRA | Collaborative Research Alliance |
| CSD | Computational Sciences Division of the CISD |
| CTA | Collaborative Technology Alliance |
| DARPA | Defense Advanced Research Projects Agency |
| DE | directed energy |
| DFT | density functional theory |
| DMAZ | dimethylamino-2-ethylazide |
| DNS | direct numerical simulation |
| DoD | Department of Defense |
| DOE | Department of Energy |
| DRI | Director’s Research Initiative |
| DSI | Director’s Strategic Initiative |
| DU | depleted uranium |
| EAR | environment for auditory research |
| EASE | executable architecture systems engineering |
| ECAE | equal channel angle extrusion |
| ECG | electrocardiography |
| EEG | electroencephalogram |
| EFP | explosively formed penetrator |
| EIS | electrochemical impedance spectroscopy |
| EM | electromagnetic |
| EMG | electromyography |
| EMVAF | Electro Magnetic Vulnerability Assessment Facility |
| EOCM | electro-optic countermeasures |
| EO&P | Electro-optics and Photonics (Division) |
| EPAs | embodied pedagogical agents |
| ERA | explosive reactive armor |
| ESAPI | enhanced small arms protective inserts |
| FAST | field assistance in science and technology |
| FCS | future combat systems |
| FEA | finite-element analysis |
| FEM | finite-element modeling |
| fMRI | functional magnetic resonance imaging |
| FPGA | field-programmable gate array |
| FY | fiscal year |
| GCV | ground combat vehicle |
| GIFT | generalized intelligent framework for tutoring |
| GLEEM | gun liner emplacement by elastomeric materials |
| GNC | guidance, navigation, and control |
| GPS | Global Positioning System |
| GPU | graphics processing unit |
| GSR | galvanic skin response |
| GUI | graphical user interface |
| HP | horsepower |
| HPC | high-performance computing |
| HRED | Human Research and Engineering Directorate |
| HRI | human–robot interaction |
| HSI | human system integration |
| ICA | independent component analysis |
| ICT | Institute for Creative Technology |
| IED | improvised explosive device |
| IEEE | Institute of Electrical and Electronics Engineers |
| IEPD | Information and Electronic Protection Division |
| IGF | intergranular grain-boundary film |
| IM | insensitive munitions |
| IMPRINT | Improved Performance Research Integration Tool |
| IMU | inertial measurement unit |
| INSCOM | Intelligence Security Command |
| INVA/DE | integrated network vulnerability assessment/discovery exploitation |
| IO | information operations |
| IPA | Intergovernmental Personnel Act |
| IR | infrared |
| IRCM | infrared countermeasure |
| IRFNA | inhibited red fuming nitric acid |
| ISD | Information Sciences Division |
| ISR | intelligence, surveillance, and reconnaissance |
| ITA | International Technology Alliance |
| JP-8 | jet propellant 8 (fuel) |
| KE | kinetic energy |
| LED | light-emitting diode |
| LES | large-eddy simulation |
| LIF | laser-induced fluorescence |
| LIFE | laser IRCM flyout experiment |
| Li-ion | lithium ion |
| LWIR | long-wavelength infrared |
| M&S | modeling and simulation |
| MADIS | meteorological assimilation data ingest system |
| MANPRINT | manpower and personnel integration |
| MASINT | measurement and signature intelligence |
| MAST | micro-autonomous systems and technology |
| MBT&E | mission-based test and evaluation |
| MEDE | materials in extreme dynamic environments |
| MEMS | microelectromechanical systems |
| MMF | Mission and Means Framework (software) |
| MOUT | military operations on urban terrain |
| MRAP | mine-resistant ambush-protected |
| MSME | multiscale multidisciplinary modeling of electronic materials |
| MT | machine translation |
| MURI | Multidisciplinary University Research Initiative |
| MUVES | Modular UNIX-based Vulnerability Estimation Suite (software) |
| NASA | National Aeronautics and Space Administration |
| NC | nanocellulose |
| NDE | nondestructive evaluation |
| NERA | nonexplosive reactive armor |
| NLOS | non-line-of-sight |
| NMR | nuclear magnetic resonance |
| NOAA | National Oceanographic and Atmospheric Administration |
| NRC | National Research Council |
| NSD | Network Sciences Division |
| NSF | National Science Foundation |
| NWS | National Weather Service |
| OA | optical augmentation |
| OCR | optical character recognition |
| ODE | ordinary differential equation |
| ODR | opportunity-driven research |
| ODT | omnidirectional treadmill |
| OEO | opto-electronic oscillator |
| ONR | Office of Naval Research |
| ORCA | operational requirements-based casualty assessment |
| OSD | Office of the Secretary of Defense |
| PASS | personal academic strategies for success |
| PDV | photon doppler velocimetry |
| PFM | phase field modeling |
| PSL | Physical Sciences Laboratory (at New Mexico State University) |
| PTSD | post-traumatic-stress disorder |
| QAM | quadrature amplitude modulation |
| QE | quantum efficiency |
| QMU | quantify the margin of uncertainty |
| QWIP | quantum-well infrared photodetector |
| R&D | research and development |
| RDEC | Research, Development, and Engineering Center |
| RDECOM | Research, Development, and Engineering Command |
| RF | radio frequency |
| RTDS | real-time digital simulator |
| S&T | science and technology |
| S4 | System-of-Systems Survivability Simulation (software) |
| SAFTE | sleep, activity, fatigue and task effectiveness |
| SBAM | scalable binary annular munition |
| SBIR | small business innovation research |
| SEDD | Sensors and Electron Devices Directorate |
| SEI | solid electrolyte interface |
| SEMACS | specialty electronics, materials, and sensors (program) |
| SiC | silicon carbide |
| SiC-N | silicon carbide-new |
| SIRE | Synchronous Impulse Reconstruction |
| SLAD | Survivability/Lethality Analysis Directorate |
| SLAM | simultaneous localization and mapping |
| SLV | survivability, lethality, and vulnerability |
| SLVA | survivability, lethality, and vulnerability assessment |
| SME | subject-matter expert |
| SNA | social network analysis |
| SOFC | solid oxide fuel cell |
| SoS | system-of-systems |
| SoSA | system-of-systems analysis |
| SPEAR | soldier performance and equipment advanced research |
| STTC | Simulation and Training Technology Center |
| STTR | small business technology transfer |
| STEM | science, technology, engineering, and mathematics |
| SWaP | space, weight, and power |
| T&E | testing and evaluation |
| TARDEC | Tank Automotive Research, Development, and Engineering Center |
| TBI | traumatic brain injury |
| TEM | transmission electron microscopy |
| THINK | tactical human integration of networked knowledge |
| THz | terahertz |
| TILV | target interaction lethality/vulnerability |
| TMEDA | N,N,N’,N’-tetramethylethylenediamine |
| TN | translational neuroscience |
| TNT | 2,4,6-trinitrotoluene |
| TRAC | Training and Doctrine Command Analysis Center |
| TRADOC | Training and Doctrine Command |
| TTPs | tactics, techniques, and procedures |
| TTR | through-thickness reinforcement |
| TWV | tactical wheeled vehicle |
| UAS | unmanned autonomous system |
| UAV | unmanned aerial vehicle |
| UBB | underbody blast |
| UGV | unmanned ground vehicle |
| UV | ultraviolet |
| V&V | validation and verification |
| VAATE | Versatile Affordable Advanced Turbine Engines (program) |
| VAPP | very affordable precision projectile |
| VARD | Vehicle Applied Research Division |
| VBS2 | Virtual Battlespace 2 |
| VSL | virtual shot line |
| VTD | Vehicle Technology Directorate |
| VTOL | vertical takeoff and landing |
| WC | tungsten carbide |
| WEL | Wireless Emulation Laboratory |
| WFO | warfighter outcome |
| WHA | tungsten heavy alloy |
| WIAMan | warrior injury assessment manikin |
| WMRD | Weapons and Materials Research Directorate |
| WRF | weather research and forecast |