Heritable Genetic Modification in Food Animals (2025)
Chapter: Appendix A: Public Meeting Agendas
Appendix A
Public Meeting Agendas
COMMITTEE ON HERITABLE GENETIC MODIFICATION IN FOOD ANIMALS
National Academy of Sciences Building, 2101 Constitution Ave., NW
Washington, DC 20418
OCTOBER 18, 2023
SESSION 1 – OPEN
OPEN SESSION WITH SPONSORS
| 8:00 | Welcome |
| 8:20 |
Marina O’Reilly, National Institutes of Health
Adam Moyer, Leader, Animal Biotechnology Team, FDA/CVM Namandje Bumpus, Chief Scientist, FDA Alexis Norris, Bioinformatics Reviewer, Animal Biotechnology Team, FDA/CVM |
| 10:10 | Break |
COMMITTEE ON HERITABLE GENETIC MODIFICATION IN FOOD ANIMALS
Keck Center, 500 5th St. NW
Washington, DC 20001
FEBRUARY 27, 2024
SESSION 1 – OPEN
METHODS FOR GENERATING HERITABLE GENETIC
MODIFICATIONS IN FOOD ANIMALS
| 8:30 |
Progress toward more precise CRISPR-based vectors
Jonathan Gootenberg and Omar Abudayyeh (Harvard University) – New genome-editing tools (virtual) Jon Oatley (Washington State University) – Applications to livestock General discussion |
| 9:30 | Break |
SESSION 2 – OPEN
HORIZON SCAN – WHAT TRAITS MIGHT BE PURSUED
WITHIN THE NEXT TWO YEARS?
| 9:45 |
Mike McGrew (Roslin Institute) – Poultry
Dan Carlson (Recombinetics) – Ruminant mammals Kevin Wells (University of Missouri) – Pigs Ross Houston (Benchmark Genetics) – Aquatic species Martin Lema (National University of Quilmes) – A view from Argentina General discussion |
| 12:30 | Lunch |
SESSION 3 – OPEN
VIEWS OF STAKEHOLDERS
| 2:00 |
Panel 1 - Industry
1) How the biotech industrial sector perceives agricultural animal biotechnologies, 2) What are the priority traits that the industry is most interested in developing, 3) Which are most likely to be targeted by GM (e.g., single gene traits)? 4) What are industry concerns about GM? Tad Sonstegard (Acceligen) Elena Rice (Genus) Bo Harstine (Select Sires) Panel discussion |
| 3:15 | Break |
| 3:30 |
Panel 2 - Public agencies, consumers, and the public
Steven Moeller (USDA-ARS Food Animal Production Program) Adam Moyer (U.S. Food and Drug Administration) Jennifer Kuzma (North Carolina State University) – Risk and public perception (virtual) |
| 4:00 | Panel discussion |
SESSION 4 – OPEN
ANIMAL WELFARE
| 4:30 | Mark Tizard (CSIRO) – Australian view, including sex-sorted chickens General discussion |
FEBRUARY 28, 2024
SESSION 5 – OPEN
GENOME ANNOTATION AND RELATION TO FOOD SAFETY OF HGM ANIMALS
| 8:00 |
Fiona McCarthy (University of Arizona) – Issues in genome annotation
Peter Harrison (EMBL’s European Bioinformatics Institute, UK) – Functional annotation of animal genomes (virtual) Terence Murphy (NCBI) – Structural annotation of genomes from a comparative perspective; what can be done automatically or by Ensembl; research needs and community expertise Discussion |
SESSION 6 – OPEN
BIOLOGICAL MECHANISMS THAT MAY PRESENT NOVEL HAZARDS
| 9:20 |
Change in food composition/quality due to transgene expression/gene editing
Allison Van Eenennaam (UC-Davis) – Animal health and food safety analyses of six offspring of a genome-edited hornless bull Fred Gould (North Carolina State University) – Can proposed multi-omics-based regulation of crops be applied to animals? Discussion |
| 10:20 | Break |
SESSION 7 – OPEN
NOVEL RESISTANCE TO DISEASE
| 10:40 |
Darrell Kapczynski (USDA-ARS) – Introduction to avian influenza, current global situation, importance, wild birds, spillover to mammals
Julie Lenoch (USDA-APHIS) – Are we driving pathogen evolution? Could resistant livestock become a reservoir for disease? Shayan Sharif (University of Guelph, Canada) – Perspectives on vaccination as an approach for control of highly pathogenic avian influenza viruses: challenges and opportunities Wendy Barclay (Imperial College London) – Perspective on producing birds and testing |
| 11:30 | Discussion |
| 12:30 | Lunch |
SESSION 8 – OPEN
GENOMICS
What is the degree of variation among breeds, individuals and generations?
What can livestock 1,000-genome projects teach us about frequencies of mutations and, hence, our ability to detect off-targets in genome-edited livestock?
Do we need breed-specific genome projects?
| 2:00 |
Michel Georges (University of Liege, Belgium) – Belgian Blue and Holstein cattle
Elena Rice (Genus) – Pigs Rachel Hawken (Cobb-Vantress) – Chickens Discussion |
| 2:40 | Break |
COMMITTEE ON HERITABLE GENETIC MODIFICATION IN FOOD ANIMALS
Keck Center, 500 5th St., NW
Washington, DC 20001
JULY 23, 2024
SESSION 1 – OPEN
RECENT REGULATORY ACTIVITIES REGARDING HGM ANIMALS
| 8:30 | Laura Epstein (U.S. Food and Drug Administration – Center for Veterinary Medicine) – Scientific and legal aspects of proposed changes to Guidance for Industry 187 |
| 9:00 | Jennifer Rowland (U.S. Department of Agriculture - Office of the Chief Economist) – MOU with FDA for coordinating oversight of HGM animals |
| 9:30 | Discussion |
SESSION 2 – OPEN
SCIENTIFIC ISSUES POSED BY HGM ANIMALS
| 10:30 | Phil Johnson (University of Nebraska) – Allergenic potential of HGM animal food products |
| 11:00 | Larisa Rudenko (MIT and BioPolicy Solutions, LLC) – Risk assessment and demonstration of safety of foods from HGM animals |
| 11:30 | Discussion |
| 12:30 | Lunch |
