Despite being preventable and curable, tuberculosis (TB) has been a deadly disease that continues to sicken and kill millions each year, mostly in poor and vulnerable populations in the world. COVID-19 has taken a devastating toll on the global TB response, threatening to reverse up to twelve years of progress. With support from the United States Agency for International Development, a planning committee of the National Academies of Sciences, Engineering, and Medicine has convened to organize a public workshop to explore innovations needed to meet the targets set in the World Health Organization's End TB Strategy by 2030.