Lyme disease is the most commonly reported vector-borne disease in the United States. While most cases are effectively treated through oral antibiotics, some patients develop persistent and debilitating symptoms that last months to years despite standard antibiotic treatment. Ticks that spread Lyme disease can also carry other pathogens, leading to potential co-infection and further complicating diagnosis and treatment.

Under the auspices of the National Academies of Sciences, Engineering, and Medicine, an ad hoc committee will conduct a study to assess the current evidence base for treatment of Lyme infection-associated chronic illnesses to identify research priorities and new opportunities.