Sufficient Evidence of a Causal Relationship

• Benzene and acute leukemia

Sufficient Evidence of an Association

• Benzene and adult leukemia

• Solvents and acute leukemia

Limited/Suggestive Evidence of an Association:

• Tetrachloroethylene and dry-cleaning solvents and bladder cancer

• Solvents and bladder cancer

• Tetrachloroethylene and dry-cleaning solvents and kidney cancer

• Organophosphorous insecticides and non-Hodgkin’s lymphoma

• Carbamates and non-Hodgkin’s lymphoma

• Benzene and non-Hodgkin’s lymphoma

• Solvents and multiple myeloma

• Organophosphorous insecticides and adult leukemia

• Solvents and adult leukemia

• Solvents and myelodysplastic syndromes

Inadequate/Insufficient Evidence to Determine Whether an Association Exists:

• Solvents and oral, nasal, or laryngeal cancer

• Insecticides and pancreatic cancer

• Solvents other than tetrachloroethylene and dry-cleaning solvents and esophageal cancer

• Solvents and stomach, rectal, or pancreatic cancer

• Solvents other than trichloroethylene and mixtures of benzene, toluene, and xylene and colon cancer

• Insecticides and solvents and hepatobiliary cancers

• Insecticides and lung cancer

• Solvents other than tetrachloroethylene and dry-cleaning solvents and lung cancer

• Solvents and bone cancer

• Solvents and melanoma or nonmelanoma skin cancer

• Insecticides and soft tissue sarcomas

• Lindane and solvents and breast cancer

• Solvents other than trichloroethylene and cervical cancer

• Solvents and ovarian or uterine cancer

• Insecticides and prostate, testicular, bladder, or kidney cancers

• Specific solvents other than tetrachloroethylene and dry-cleaning solvents and bladder cancer

• Solvents other than tetrachloroethylene and dry-cleaning solvents and kidney cancer

• Solvents and prostate cancer

• Insecticides and brain and other central nervous system cancers

• Specific solvents other than benzene and brain and other central nervous system cancers

• Specific solvents other than benzene and non-Hodgkin’s lymphoma

• Insecticides and solvents and Hodgkin’s disease

• Insecticides and specific solvents and multiple myeloma

• Specific solvents other than benzene and acute and adult leukemia

• Benzene and myelodysplastic syndrome

• Parental preconception exposure to insecticides and childhood leukemias, brain and other central nervous system cancers or non-Hodgkin’s lymphoma

• Parental preconception exposure to solvents and neuroblastoma or childhood brain cancers

Limited/Suggestive Evidence of NO Association

• No findings

Sufficient Evidence of a Causal Relationship

• No findings

Sufficient Evidence of an Association

• No findings

Limited/Suggestive Evidence of an Association:

• Organophosphorous insecticide exposure with OP poisoning and long-term neurobehavioral effects (that is, abnormal results on neurobehavioral test batteries and symptom findings)

• Solvents and neurobehavioral effects (that is, abnormal results on neurobehavioral test batteries and symptom findings)

Inadequate/Insufficient Evidence to Determine Whether an Association Exists:

• Insecticides and solvents and peripheral neuropathy

• Insecticides and solvents and Parkinson’s Disease

• Insecticides and solvents and amyotrophic lateral sclerosis

• Insecticides and solvents and Alzheimer’s Disease

• Solvents and multiple sclerosis

• Solvents and a long-term reduction in color discrimination

• Solvents and long-term hearing loss

• Solvents and long-term reduction in olfactory function

Limited/Suggestive Evidence of NO Association

• No findings

Sufficient Evidence of a Causal Relationship

• No findings

Sufficient Evidence of an Association

• No findings

Limited/Suggestive Evidence of an Association:

• No findings

Inadequate/Insufficient Evidence to Determine Whether an Association Exists:

• Insecticides and solvents and male or female infertility after cessation of the exposure

• Parental preconception exposure to insecticides or solvents and spontaneous abortion or other adverse pregnancy outcomes

• Parental preconception exposure to insecticides or solvents and congenital malformations

Limited/Suggestive Evidence of NO Association

• No findings

Sufficient Evidence of a Causal Relationship

• Benzene and aplastic anemia

Sufficient Evidence of an Association

• Propylene glycol and allergic contact dermatitis

Limited/Suggestive Evidence of an Association:

• Solvents and reactive airways dysfunction syndrome (RADS) which would be evident with exposure and could persist for months or years

• Solvents and hepatic steatosis

• Solvents and chronic glomerulonephritis

• Insecticides and allergic contact dermatitis

Inadequate/Insufficient to Determine Whether an Association Exists:

• Insecticides and aplastic anemia

• Solvents other than benzene and aplastic anemia

• Insecticides and solvents and irreversible cardiovascular outcomes

• Insecticides and solvents and persistent respiratory symptoms or impairment after cessation of exposure

• Solvents and alterations in liver function tests after cessation of exposure

• Solvents and cirrhosis

• Solvents and chronic pancreatitis or other persistent gastrointestinal outcomes

• Solvents and the systemic rheumatic diseases: scleroderma, rheumatoid arthritis, undifferentiated connective tissue disorders, and systemic lupus erythematosus

Limited/Suggestive Evidence of NO Association

• No finding