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Suggested Citation: "Appendix G: Positron Emission Tomography Radiopharmaceuticals." National Research Council. 2012. Assuring a Future U.S.-Based Nuclear and Radiochemistry Expertise. Washington, DC: The National Academies Press. doi: 10.17226/13308.

Positron Emission Tomography Radiopharmaceuticals

TABLE G-1 Positron Emission Tomography Radiopharmaceuticals


Trade Name	Radiopharmaceutical	Clinical Indication

Ammonia N13	13N-Ammonia	Myocardial blood flow
Cardio-Gen	⁸²Rb-Rubidium chloride	Myocardial blood flow
Florbetapir F18 ^**	¹⁸F-styryl-pyridine	Amyloid Plaques Alzheimer’s disease
Fluorbetabane F18^#	¹⁸F-styryl-pyridine	Amyloid Plaques Alzheimer’s disease
Flutemetamol F18^#	¹⁸F-hydroxy-benzothiazole	Amyloid Plaques Alzheimer’s disease
Fluorpiridaz F18^#	¹⁸F-pyridazinone	Myocardial blood flow
Fludeoxyglucose F18 Injection	¹⁸F-Fluorodeoxyglucose	Oncology,Myocardial Viability, Seizure Foci
Sodium Fluoride F18	Sodium ¹⁸F-fluoride	Bone scans
Single Photon Emission Computed Tomography (SPECT) Radiopharmaceuticals
Chromitope Mallinkrodt Cr-51	Sodium ⁵¹Cr-chromate	Red Blood Cell Labeling
Ga-67	⁶⁷Ga-Gallium citrate	Soft tissue tumor, Inflammatory processes
Indium In 111 oxyquinoline	111In-Indium oxyquinoline	Luekocyte and platlet labeling
MPI Indium DTPA In 111	¹¹¹In-Indium Pentetate disodium	Cerebrospinal fluid kinetics
ProstaScint	¹¹¹In-Indium Capromab Pendetide	Prostate Tumor
Octreoscan	¹¹¹In-Indium Pentetreotide	Neuroendocrine tumors Gastroenteropancreatic tumors
Zevalin	¹¹¹In -Ibitumonmab iuxetan	non-Hodgkin’s lymphoma
Sodium Iodide I 123	Sodium ¹²³I-iodide	Thyroid uptake
Datscan	¹²³I-Ioflupane	Striatal Dopaminae Transporters
Adreview	¹²³I-Iobenguane	Pheochromacytoma, Neuroblastoma
Glofil	¹²⁵I-Iothalamate	Glomerular filtration measurement
Jeanatope	¹²⁵I-human Serum Albumin	Total blood and plasma volume
Megatope	¹³¹I-human Serum Albumin	Total blood and plasma volume
Bexxar	¹³¹I-Tositumomab	non-Hodgkin’s lymphoma
Sodium Iodide I 123	Sodium ¹²³I-iodide	Thyroid uptake
Technetium Generator	^99mTc-Pertechnetate	Thyroid, salivary and parathyroid
Technelite		glands, ectopic gastric mucosa,
Ultra-Technekow FM		dacryocystography, cystography
Neurolite	^99mTc-Bicisate (ECD)	Cerebral Perfusion
Hepatolite-CIS	^99mTc-Disofenin (DISIDA)	Hepatobiliary function
Ceretec	^99mTc-Exametazine (HMPAO)	Cerebral Perfusion

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Trade Name	Radiopharmaceutical	Clinical Indication

Pulmolite	^99mTc-Aggregated albumin	Pulmonary Perfusion
Technetium Tc 99M Albumin Aggregated Kit
Choletec	^99mTc-Mebrofenin	Hepatobiliary function
Osteolite	^99mTc-Medronate (MDP)	Bone imaging
Technescan MAG3	^99mTc-Mertiatide	Renal function
Techneplex DTPA	^99mTc-Pentetate	Renal function, Radioaresol ventilation
Phosphotec Pyrolite Pyro Technescan PYP Amersham PYP	^99mTc-Pyrophosphate (PYP)	Infarct imaging, in vivo Red blood cell labeling
Cardiolite Miraluma	^99mTc-Sestamibi	Myocardial blood flow, Breast tumor
DMSA	^99mTc-Succimer (DMSA)	Renal function
Sulfur Colloid	^99mTc-Sulfur Colloid	Liver/spleen gastric emptying, GI bleeds
AN-Sulfur Colloid
Myoview	^99mTc-Tetrofosmin	Myocardial blood flow
Thallium	²⁰¹Tl-Thallium chloride	Myocardial blood flow, Parathyroid, Tumor
Xenon	¹³³Xe-xenon gas	Pulmonary ventilation
Radiotherapeutics
Zevalin	⁹⁰Y-Ibitumonmab Tiuxetan	non-Hodgkin’s lymphoma
Bexaar	¹³¹I-Tositumomab	non-Hodgkin’s lymphoma
Metastron	⁸⁹Sr-strontium	bone pain from skeletal metastases
Quadramet	¹⁵³Sm Lexidronin	bone pain from skeletal metastases
Sodium Iodide I 131	Sodium ¹³¹I-iodide	Thyroid therapy
HICON
Phosphocol 32	32P-Chromicphosphate	Intracavity malignancies

^** Conditionally approved by the FDA

^# in Phase 3 clinical trials

SOURCE: NRC/IOM 2007; FDA 2011; UAMS 2011

REFERENCES

FDA (U.S. Food and Drug Administration). 2011. Orange Book: Approved Drug Products with Therapeutic Equivalence Evaluations. U.S. Food and Drug Administration [online]. Available: http://www.accessdata.fda.gov/scripts/cder/ob/default.cfm [accessed November 21, 2011].

NRC/IOM (National Research Council and Institute of Medicine). 2007. Appendix C. Commercially available radiopharmaceuticals. Pp. 151-154 in Advancing Nuclear Medicine through Innovation. Washington, DC: The National Academies Press.

UAMS (University of Arkansas for Medical Sciences). 2011. Radiopharmaceutical List and Package Inserts. Nuclear Pharmacology, College of Pharmacy, University of Arkansas for Medical Sciences [online]. Available: http://nuclearpharmacy.uams.edu/resources/PackageInserts.asp [accessed October 24, 2011].

Assuring a Future U.S.-Based Nuclear and Radiochemistry Expertise (2012)

Chapter: Appendix G: Positron Emission Tomography Radiopharmaceuticals

My Academies

Assuring a Future U.S.-Based Nuclear and Radiochemistry Expertise (2012)

Chapter: Appendix G: Positron Emission Tomography Radiopharmaceuticals