Addressing Treatment Resistance in the Development of Cancer Immune Modulator Therapeutics: Proceedings of a Workshop (2024)
Chapter: Appendix A: Statement of Task
Visit
NAP.edu/10766
to get more information about this book, to buy it in print, or to
download it as a free PDF.
Previous Chapter:
Proceedings of a Workshop
Appendix A
Next Chapter: Appendix B: Workshop Agenda
Suggested Citation:
"Appendix A: Statement of Task." National Academies of Sciences, Engineering, and Medicine. 2024. Addressing Treatment Resistance in the Development of Cancer Immune Modulator Therapeutics: Proceedings of a Workshop. Washington, DC: The National Academies Press.
doi: 10.17226/27517.
Appendix A
Statement of Task
A National Academies of Sciences, Engineering, and Medicine planning committee will plan and host a 1.5-day public workshop that will examine the current challenges related to resistance to immune modulator therapies for cancer and discuss potential policy levers that could help to overcome these challenges. The workshop will feature invited presentations and panel discussions on topics that may include
- An overview of the unique types of immunotherapy resistance based on the causes of resistance, including whether resistance mechanisms vary among different agents, and gaps in current understanding.
- Policy challenges and opportunities to address the problem of resistance, including
- Criteria to move single agents into clinical trials,
- Criteria to use single agents in combination therapy development (e.g., whether clinical response is necessary),
- Criteria to assess cancer immunotherapy combinations in early-phase clinical trials,
- The roles of preclinical modeling and clinical and predictive biomarkers (e.g., companion diagnostics, in vivo imaging) for assessing safety and efficacy,
- The types of clinical trial designs needed for regulatory approval, and
- Use of big data to aid in determining the dominant drivers of cancer immunotherapy resistance and to predict immunotherapy responses.
Suggested Citation:
"Appendix A: Statement of Task." National Academies of Sciences, Engineering, and Medicine. 2024. Addressing Treatment Resistance in the Development of Cancer Immune Modulator Therapeutics: Proceedings of a Workshop. Washington, DC: The National Academies Press.
doi: 10.17226/27517.
The planning committee will develop the agenda for the workshop sessions, select and invite speakers and discussants, and moderate the discussions. A proceedings of the presentations and discussions at the workshop will be prepared by a designated rapporteur in accordance with institutional guidelines.
Suggested Citation:
"Appendix A: Statement of Task." National Academies of Sciences, Engineering, and Medicine. 2024. Addressing Treatment Resistance in the Development of Cancer Immune Modulator Therapeutics: Proceedings of a Workshop. Washington, DC: The National Academies Press.
doi: 10.17226/27517.
Suggested Citation:
"Appendix A: Statement of Task." National Academies of Sciences, Engineering, and Medicine. 2024. Addressing Treatment Resistance in the Development of Cancer Immune Modulator Therapeutics: Proceedings of a Workshop. Washington, DC: The National Academies Press.
doi: 10.17226/27517.
Subscribe to Email from the National Academies
Keep up with all of the activities, publications, and events by subscribing to free updates by email.