THE NATIONAL ACADEMIES OF SCIENCES, ENGINEERING, AND MEDICINE
Policy and Global Affairs
Committee on Science, Technology, and Law
Committee on Ethical, Legal, and Regulatory Issues Associated with Neural Chimeras and Organoids
*****
Congressional Briefing
Friday, April 9, 2021 – 2:00 p.m.
via Zoom
on
The Emerging Field of Human Neural Organoids, Transplants, and Chimeras:
Science, Ethics, and Governance
Each year, tens of millions of individuals in the U.S. suffer from neurological and psychiatric disorders including neurodegenerative diseases such as Alzheimer's Disease and Parkinson's Disease, and psychiatric disorders such as autism spectrum disorder, depression and schizophrenia. Treatments for these diseases are often completely lacking or only partially effective, due in large part to the difficulty of conducting brain research and the complexity of the brain itself.
Researchers in recent years have developed new models to better represent and study the human brain. The three models considered in this report, all of which generate and use pluripotent stem cells from healthy individuals and patients, are human neural organoids, human neural transplants, and human-animal neural chimeras.
This new report, from the National Academies of Sciences, Engineering, and Medicine, reviews the status of research, considers its benefits and risks, discusses associated ethical issues, and considers governance mechanisms for this type of research.
This briefing was for members of Congress and congressional staff only. The report was publicly released on April 8, 2021 and can be found, in its entirety, on the Web site of the National Academies Press.