September 23, 2021
Web Meeting
Times in EST
| 1:00 | Welcome Cliff Duke, Director, BEST |
| 1:05 | Chair’s Opening Remarks and Introduction of Committee Members Weihsueh Chiu |
| 1:30 | Question and Answer Session on the Statement of Task Rusty Thomas or other EPA staff and Committee Members |
| 2:00 | Opportunity for Public Comment |
| 2:15 | Adjourn Open Session |
December 9, 2021
Virtual Workshop
Times in EST
| 10:00 | Welcome, Introduction to Committee and Charge Questions Kate Guyton, National Academies Project Director Weihsueh Chiu, Committee Chair |
| Session I: How are traditional mammalian toxicity studies used in informing chemical safety decisions? | |
| 10:25 | Summary of Pre-Recorded Presentations, Panel Discussion, and Committee Q&A Moderators: Weihsueh Chiu and Tracey Woodruff |
| Risk assessment introduction, contexts and challenges Thomas Burke, Johns Hopkins University |
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| Hazard identification of endocrine agents Sharon Munn, Joint Research Centre |
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| Hazard identification and dose-response of carcinogens Vincent Cogliano, California Environmental Protection Agency. |
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| Insights from recent NASEM committees: Predicting acute toxicity and a class approach to organohalogens David Dorman, North Carolina State University |
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| Session II: What do we know about the variability of traditional mammalian toxicity studies with different levels of complexity? | |
| 11:25 | Summary of Prerecorded Presentations, Panel Discussion, and Committee Q&A Moderators: Nicole Kleinstreuer and Holly Davies |
| Variability within the same traditional mammalian toxicity studies David Allen, Integrated Laboratory Systems, LLC |
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| Variability among traditional mammalian toxicity studies of the same and different design Katie Paul Friedman, U.S. Environmental Protection Agency |
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| Variability within and across species in traditional mammalian toxicity studies Suzanne Fenton, National Toxicology Program |
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| Systematic reviews and meta-analyses Malcolm Macleod, University of Edinburgh |
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| Session III: What do we know about the concordance of traditional mammalian toxicity studies with humans? | |
| 12:40 | Summary of Prerecorded Presentations, Panel Discussion, and Committee Q&A Moderators: Nancy Lane and Patience Browne |
| Concordance of traditional mammalian toxicity studies with human clinical outcomes Thomas Hartung, Johns Hopkins University |
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| Concordance between animal and human toxicology Joshua Robinson, University of California, San Francisco |
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| Application of systematic review methods in low-dose endocrine toxicity David Dorman, North Carolina State University |
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| Session IV: Panel Reflections | |
| 1:40 | Panel Reflections and Q&A from Committee Moderators: Kristi Pullen Fedinick and Corie Ellison |
| Panelists: | |
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| 2:40 | Public Comment Period |
| 3:00 | Adjourn |
May 12, 2022
Virtual Workshop
Times in EST
| 11:00 | Welcome, Introduction to the committee and the charge questions Kate Guyton, National Academies Project Director Weihsueh Chiu, Committee Chair |
| Session I: Mixtures | |
| 11:20 | Summary of Prerecorded Presentations, Panel Discussion, and Committee Q&A Moderators: Kim Boekelheide and Weihsueh Chiu |
Panelists:
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| Session II: Developmental Neurotoxicity | |
| 12:40 | Summary of Prerecorded Presentations, Panel Discussion, and Committee Q&A Moderators: Robyn Tanguay and Heather Patisaul |
Panelists:
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| Session III: Estrogenicity | |
| 2:00 | Summary of Prerecorded Presentations, Panel Discussion, and Committee Q&A Moderator: Nicole Kleinstreuer and Marie Fortin |
| Panelists: | |
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| 3:10 | Public Comment Period |
| 3:30 | Adjourn |
July 28, 2022
Web Meeting
Times in EST
| 1:00 | Welcome and Introductions Kate Guyton, National Academies Project Director Weihsueh Chiu, Committee Chair |
| 1:15 | EPA Presentations Maureen Gwinn, PhD DABT, US EPA Russell Thomas, PhD, US EPA |
| 1:45 | Committee Q&A |
| 2:30 | Opportunity for Public Comment |
| 2:45 | Adjourn Open Session |