The geodetic infrastructure and its products, notably the terrestrial reference frame, provides the information needed to pinpoint the locations of satellite, aircraft, and ground-based instruments and the geophysical phenomena they are tracking. Thus, the geodetic infrastructure is essential for supporting scientific inquiries that require precise measurements of location and time, such as sea-level rise, ice-sheet change, and earthquake deformation. This study is aimed at helping discipline scientists understand how their research connects with the underlying terrestrial reference frame and helping NASA and other federal agencies understand how the terrestrial reference frame needs to evolve to answer priority science questions.