The Board on Environmental Studies and Toxicology (BEST) will convene an ad hoc committee to examine applications of numerous scientific tools and approaches for incorporating sustainability concepts into assessments used to support EPA decision making. Using specific case studies it develops (e.g., environmental media and sector-based), the committee will consider the application of analytic and scientific tools, methods, and approaches in the Sustainability Assessment and Management (SAM) process presented in the 2011 NRC report Sustainability and the U.S. EPA.