The committee evaluates submissions received in response to a Request for Proposals for biomolecular simulation time on Anton 2, a supercomputer specially designed and built by D.E. Shaw Research (DESRES). For several years, DESRES has made an Anton or Anton 2 system housed at the Pittsburgh Supercomputing Center available to the non-commercial research community, based on the advice of previous National Academies committees. The goal is to continue to facilitate breakthrough research in the study of biomolecular systems by providing a massively parallel system specially designed for molecular dynamics simulations.