The Forum on Microbial Threats will host a public workshop to examine how genomics technologies have been applied to disease surveillance and response and identify potential opportunities for broader adoption in public health. High-throughput and genome sequencing technologies have enabled the use of pathogen genomics and metagenomics as powerful data-driven disease surveillance approaches. These epidemiological tools have been critical in addressing emerging outbreaks and evolving pathogens from foodborne infections to SARS-CoV-2. This workshop will examine opportunities to integrate pathogen genomics tools and techniques more broadly into the public health system to improve the effectiveness of surveillance and response to diseases.