A National Academies of Sciences, Engineering, and Medicine planning committee will organize and host a 1.5-day public workshop that will examine the state of the science for clinical use of multicancer early detection tests. The workshop will feature invited presentations and panel discussions on topics that may include:

• The rationale for detecting multiple cancers with a single test.
• Examples of current and emerging tests to screen for multiple types of cancer.
• Challenges to validate multicancer early detection tests and determine their clinical utility for detecting cancer and reducing cancer-specific mortality.
• Limitations of multicancer tests, including the burden on patients and health care systems from false-positive test results, overdiagnosis, and overtreatment.
• Strategies for cancer care downstream of multicancer testing, such as follow-up diagnostic tests and treatment decision-making.
• Key research and policy gaps for assessing multicancer early detection tests and their impact on cancer care and outcomes and health equity.
• Potential for public-private partnerships to address challenges in assessing the effectiveness of clinical implementation of multicancer tests.

The planning committee will develop the agenda for the workshop sessions, select and invite speakers and discussants, and moderate the discussions. A proceedings of the presentations and discussions at the workshop will be prepared by a designated rapporteur in accordance with institutional guidelines.