Exploring Sleep Disturbance in Central Nervous System Disorders: A Workshop

Workshop

November 2 - 3, 2022

Past

Discussion

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Materials

About

A planning committee of the National Academies of Sciences, Engineering, and Medicine organized and conducted a 1.5-day public workshop that brought together experts and key stakeholders from academia, industry, government, philanthropic foundations, and disease-focused non-profit organizations to explore the role of sleep in central nervous system (CNS) disorders and opportunities to mitigate sleep disturbances commonly associated with these disorders.

Invited presentations and discussions:

Examined the prevalence and nature of sleep disturbances across CNS disorders;
Reviewed the current state of knowledge regarding the mechanisms, function, and characterization of sleep, including changes across the human lifespan;
- Considered opportunities to better understand underlying mechanisms of sleep by leveraging advances from ongoing efforts (e.g., the BRAIN Initiative) to integrate behavioral outputs with brain network and neural circuit activity;
Explored how a genes-first approach can illuminate the bi-directional relationship between disturbed sleep and CNS disorders;
Considered potential relationships among disturbed sleep, CNS disorders, and environmental factors associated with both disturbed sleep and increased risk for CNS disorders, including discussing related disparities and approaches to disentangling causal versus contributing factors;
Considered the impact of altered circadian timing (in shift work, and otherwise in modern society) on sleep quantity and quality and associated co-morbidities e.g. CNS disorders;
Explored the potential of sleep as a mitigatable target by drugs, devices, and behavioral modifications, as well as a measurable marker related to CNS function, including standardization and common data format requirements to facilitate deeper and cross-therapeutic understanding of sleep;
Discussed research gaps and opportunities for cross-disciplinary collaboration between sleep experts and those focused on CNS disorders.

The planning committee developed the agenda for the workshop, selected and invited speakers and discussants, and moderated the discussions. A proceedings of the presentations and discussions at the workshop will be prepared by a designated rapporteur in accordance with institutional guidelines.

Contact

Eden Neleman

(202) 334-2131
eneleman@nas.edu

Location

Keck Center

500 5th St NW

Washington DC 20001, USA

Disclaimer

It is essential to the National Academies mission of providing evidence-based advice that participants in any of our meetings or events avoid political or partisan statements or commentary and maintain a culture of mutual respect. The statements and presentations during our meetings or events are solely those of the individual participants and do not necessarily represent the views of other participants or the National Academy of Sciences, which is a non-partisan, tax exempt organization that includes under its Charter the National Academy of Engineering and National Academy of Medicine, and that operates the National Research Council.

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Exploring Sleep Disturbance in Central Nervous System Disorders: A Workshop

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Exploring Sleep Disturbance in Central Nervous System Disorders: A Workshop