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The National Academies of Sciences, Engineering, and Medicine is undertaking a rapid expert consultation to assess current and emerging therapeutic options for Highly Pathogenic Avian Influenza A (H5N1) in humans. The consultation will examine the effectiveness and availability of existing treatments, identify promising therapeutics in development, and explore how these options could be most effectively deployed in the event of sustained human-to-human H5N1 transmission or a potential influenza pandemic. Experts will also discuss research needs, regulatory considerations, and allocation strategies to ensure equitable and effective use of limited supplies.