An ad hoc committee will plan and conduct a one-day public workshop to explore opportunities and challenges related to discovery, development, and translation of treatments for cognitive dysfunction in depression. The workshop will bring together key stakeholders to explore ways to improve the discovery, development and regulatory path for new treatments addressing this aspect of depression.

Presentations and discussions will be designed to:

· Examine opportunities to facilitate new target and validation strategies aimed at reinvigorating the development of treatments that address cognition, an under-treated aspect of depression.

· Discuss how lessons from the translational aspects of cognitive dysfunction in other disorders could apply to depression.

· Highlight gaps and limitations of current tools for assessing cognitive dysfunction in depression in clinical trials, and consider how improvements in cognition could relate to functional outcomes.

· Explore potential regulatory challenges, such as recognition of cognitive dysfunction in depression as a public health need and opportunities for treatments.

The committee will develop the agenda for the workshop, select and invite speakers and discussants, and moderate the discussions. An individually authored workshop summary will be prepared by a designated rapporteur based on presentations and discussions held during the workshop in accordance with institutional guidelines.