An ad hoc committee of the National Academies of Sciences, Engineering, and Medicine reviewed and conducted an analysis of the clinical trials conducted during the 2014–2015 Ebola Virus Disease (EVD) Outbreak in West Africa. The committee developed a report to inform guidelines and best practices for all future clinical trials conducted in response to a future outbreak. Particular emphasis was given to clinical trials for vaccine and therapeutic candidates for EVD conducted by the international community in settings where there is limited healthcare and research infrastructure.