Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals (2001)

Chapter: D Example of a Table of Contents of a Technical Support Document

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Suggested Citation: "D Example of a Table of Contents of a Technical Support Document." National Research Council. 2001. Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals. Washington, DC: The National Academies Press. doi: 10.17226/10122.
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Appendix D
Example of a Table of Contents of A Technical Support Document

TABLE OF CONTENTS

 

  

PREFACE

  

2

 

  

LIST OF TABLES

  

5

 

  

SUMMARY

  

6

1.

  

INTRODUCTION

  

9

2.

  

HUMAN TOXICITY DATA

  

10
   

2.1. Acute Lethality

  

10
   

2.2. Nonlethal Toxicity

  

10
   

2.2.1. Acute Studies

  

10
   

2.2.2. Epidemiologic Studies

  

11
   

2.3. Developmental/Reproductive Toxicity

  

11
   

2.4. Genotoxicity

  

11
   

2.5. Carcinogenicity

  

11
   

2.6. Summary

  

11
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Suggested Citation: "D Example of a Table of Contents of a Technical Support Document." National Research Council. 2001. Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals. Washington, DC: The National Academies Press. doi: 10.17226/10122.
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3.

  

ANIMAL TOXICITY DATA

  

11
   

3.1. Acute Lethality

  

12
   

3.1.1. Nonhuman Primates

  

12
   

3.1.2. Dogs

  

12
   

3.1.3. Rats

  

12
   

3.1.4. Mice

  

13
   

3.1.5. Hamsters

  

14
   

3.2. Nonlethal Toxicity

  

14
   

3.2.1. Nonhuman Primates

  

14
   

3.2.2. Dogs

  

14
   

3.2.3. Rats

  

15
   

3.2.4. Mice

  

15
   

3.3. Developmental/Reproductive Toxicity

  

15
   

3.4. Genotoxicity

  

18
   

3.5. Carcinogenicity

  

19
   

3.6. Summary

  

19

4.

  

SPECIAL CONSIDERATIONS

  

20
   

4.1. Metabolism and Disposition

  

20
   

4.2. Mechanism of Toxicity

  

20
   

4.3. Structure-Activity Relationships

  

21
   

4.4. Other Relevant Information

  

21
   

4.4.1. Species Variability

  

21
   

4.4.2. Unique Physicochemical Properties

  

22
   

4.4.3. Concurrent Exposure Issues

  

22

5.

  

DATA ANALYSIS FOR AEGL-1

  

22
   

5.1. Summary of Human Data Relevant to AEGL-1

  

22
   

5.2. Summary of Animal Data Relevant to AEGL-1

  

22
   

5.3. Derivation of AEGL-1

  

22

6.

  

DATA ANALYSIS FOR AEGL-2

  

23
   

6.1. Summary of Human Data Relevant to AEGL-2

  

23
   

6.2. Summary of Animal Data Relevant to AEGL-2

  

23
   

6.3. Derivation of AEGL-2

  

23

7.

  

DATA ANALYSIS FOR AEGL-3

  

24
   

7.1. Summary of Human Data Relevant to AEGL-3

  

24
   

7.2. Summary of Animal Data Relevant to AEGL-3

  

24
   

7.3. Derivation of AEGL-3

  

24
Page 181 Cite Bookmark
Suggested Citation: "D Example of a Table of Contents of a Technical Support Document." National Research Council. 2001. Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals. Washington, DC: The National Academies Press. doi: 10.17226/10122.
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8.

  

SUMMARY OF AEGLS

  

25
   

8.1. AEGL Values and Toxicity Endpoints

  

25
   

8.2. Comparison with Other Standards and Criteria

  

26
   

8.3. Data Adequacy and Research Needs

  

27

9.

  

REFERENCES CITED

  

29

Appendix A

  

(Derivation of AEGL Values)

  

32

Appendix B

  

(Time Scaling Calculations for Dimethylhydrazine AEGLs)

  

36

Appendix C

  

(Carcinogenicity Assessment for Dimethylhydrazine)

  

39

Appendix D

  

(Derivation Summary for Dimethylhydrazine AEGLs)

  

41
Page 179 Cite Bookmark
Suggested Citation: "D Example of a Table of Contents of a Technical Support Document." National Research Council. 2001. Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals. Washington, DC: The National Academies Press. doi: 10.17226/10122.
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Page 179
Page 180 Cite Bookmark
Suggested Citation: "D Example of a Table of Contents of a Technical Support Document." National Research Council. 2001. Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals. Washington, DC: The National Academies Press. doi: 10.17226/10122.
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Page 180
Page 181 Cite Bookmark
Suggested Citation: "D Example of a Table of Contents of a Technical Support Document." National Research Council. 2001. Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals. Washington, DC: The National Academies Press. doi: 10.17226/10122.
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Page 181
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