Immunization Safety Review: Vaccines and Autism (2004)

Chapter: Appendix C: Thimerosal Content in Licensed Vaccines (Adapted from FDA, 2003, 2004)

Previous Chapter: Appendix B: Public Meeting Agenda February 9, 2004
Suggested Citation: "Appendix C: Thimerosal Content in Licensed Vaccines (Adapted from FDA, 2003, 2004)." Institute of Medicine. 2004. Immunization Safety Review: Vaccines and Autism. Washington, DC: The National Academies Press. doi: 10.17226/10997.

Appendix C
Thimerosal Content in Licensed Vaccines (Adapted from FDA, 2003, 2004)

Suggested Citation: "Appendix C: Thimerosal Content in Licensed Vaccines (Adapted from FDA, 2003, 2004)." Institute of Medicine. 2004. Immunization Safety Review: Vaccines and Autism. Washington, DC: The National Academies Press. doi: 10.17226/10997.

TABLE C-1 Mercury Content from Thimerosal in the Routinely Recommended Pediatric Vaccines1 in the United States, April 2004

Vaccine

Brand Name

Manufacturer

Hg [μg/dose]

DTaP

(Diphtheria and tetanus toxoids and acellular pertussis)

Tripedia

Aventis Pasteur, Inc.

≤0.3

Infanrix

Glaxo-SmithKline

0

Daptacel

Aventis Pasteur, Ltd

0

Td1

(Tetanus and diphtheria toxoids)

None

Aventis Pasteur, Inc.

25

Decavac

Aventis Pasteur, Inc.

= 0.3

None

Aventis Pasteur, Ltd

0

None

Mass Public Health

8.3

DTaP-Hib

(Diphtheria and tetanus toxoids with acellular pertussis combined with Haemophilus influenzae type b)

TriHIBit2

Aventis Pasteur

≤0.3

Hib

(Haemophilus influenzae type b)

ActHIB/OmniHib

Aventis Pasteur, SA

0

HibTITER (Single dose)

Wyeth-Lederle

0

PedvaxHIB liquid

Merck

0

Hib/HepB (Haemophilus influenzae type b combined with Hepatitis B )

COMVAX

Merck

0

Hep B

(Hepatitis B)

(pediatric formulation)

Engerix B

Glaxo-SmithKline

<0.5

Recombivax HB

Merck

0

Influenza

Fluzone3

Aventis Pasteur, Inc.

12.5

Fluzone

Aventis Pasteur, Inc.

≤0.5ug/

(Preservative Free)

 

0.25mL dose

Pneumococcal

Prevnar

(pneumoconjugate)

Wyeth

0

IPV

(Inactivated polio vaccine)

IPOL

Aventis Pasteur, SA

0

Poliovax

Aventis Pasteur, Ltd.

0

MMR

(Measles, mumps, and rubella)

MMR-II

Merck

0

Varicella

Varivax

Merck

0

1Licensed for persons 7 years of age and older.

2For use in children 15 to 18 months of age.

3Influenza vaccine is recommended for children 6-23 months of age. MMWR (2004) 52:1-4; MMWR (2004) 53:1-3.

Suggested Citation: "Appendix C: Thimerosal Content in Licensed Vaccines (Adapted from FDA, 2003, 2004)." Institute of Medicine. 2004. Immunization Safety Review: Vaccines and Autism. Washington, DC: The National Academies Press. doi: 10.17226/10997.

TABLE C-2 Mercury Content from Thimerosal in the Currently Licensed Vaccines That Are Recommended for Some Children in the United States, April 2004

Vaccine

Brand Name

Manufacturer

Hg [μg/dose]

DT

(Diphtheria and tetanus toxoids)

All Products

Aventis Pasteur, Inc. (single dose)

0.3

 

Aventis Pasteur, Inc. (multi-dose)

25

 

Aventis Pasteur, Ltd*

25

TT (Tetanus Toxoid)

All Products

Aventis Pasteur, Inc.

25

Pneumococcal Polysaccharide

Pneumovax 23

Merck

0

Hepatitis A

Havrix

Glaxo-SmithKline

0

Vaqta

Merck

0

Influenza

Fluzone1

Aventis Pasteur, Inc.

25

Fluzone

(Preservative free)

Aventis Pasteur, Inc.

≤1 μg/0.5 mL

dose or ≤0.5 μg/

0.25 mL dose

Fluvirin

Evans

25

Fluvirin

Evans

<1 μg

Influenza, Live

FluMist

MedImmune

0

*Not available in the United States.

1Children under 3 years of age received half of a vaccine dose (0.25 mL or 12.5 μg mercury/dose).

Suggested Citation: "Appendix C: Thimerosal Content in Licensed Vaccines (Adapted from FDA, 2003, 2004)." Institute of Medicine. 2004. Immunization Safety Review: Vaccines and Autism. Washington, DC: The National Academies Press. doi: 10.17226/10997.

TABLE C-3 Mercury Content from Thimerosal in Other Licensed Vaccines in the United States, April 2004

Vaccine

Brand Name

Manufacturer

Hg [μg/dose]

Anthrax

BioThrax

BioPort Corporation

0

Smallpox

Dryvax

Wyeth

0

BCG*

 

Organon Tecknika

0

Mycobax

Aventis Pasteur, Ltd

0

Hepatitis A-Hepatitis B

Twinrix

Glaxo-SmithKline

<1 μg

Hepatitis B

Engerix B

(adult formulation)

Glaxo-SmithKline

< 0.5

 

Recombivax HB

(adult formulation)

Merck

25

 

Recombivax HB

(adult formulation)

Merck

0

Lyme*

LYMErix

Glaxo-SmithKline

0

Meningococcal1

Menomune A, C,

AC and A/C/Y/W-135

Aventis Pasteur, Inc.

(multidose)

25

 

Single dose

0

Rabies

IMOVAX

Aventis Pasteur SA

0

Rabavert

Chiron Behring

0

Typhoid Fever

Typhim Vi

Aventis Pasteur SA

0

Vivotif Berna

Berna Biotech, Ltd.

0

Yellow Fever

YF-VAX

Aventis Pasteur, Inc.

0

Japanese Encephalitis Vaccine

JE-VAX

Aventis Pasteur, Inc.

35

*Not available in the United States.

1Menomune A/C/Y/W-135, a thimerosal-containing vaccine, is not indicated for infants and children younger than 2 years of age except as short-term protection of infants 3 months and older against Group A. (Physician’s Desk Reference, 2001).

Next Chapter: Appendix D: Chronology of Important Events Regarding Vaccine Safety
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