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Suggested Citation: "Appendix C: Thimerosal Content in Licensed Vaccines (Adapted from FDA, 2003, 2004)." Institute of Medicine. 2004. Immunization Safety Review: Vaccines and Autism. Washington, DC: The National Academies Press. doi: 10.17226/10997.

Appendix C
Thimerosal Content in Licensed Vaccines (Adapted from FDA, 2003, 2004)

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TABLE C-1 Mercury Content from Thimerosal in the Routinely Recommended Pediatric Vaccines¹ in the United States, April 2004

Vaccine	Brand Name	Manufacturer	Hg [μg/dose]
DTaP (Diphtheria and tetanus toxoids and acellular pertussis)	Tripedia	Aventis Pasteur, Inc.	≤0.3
	Infanrix	Glaxo-SmithKline	0
	Daptacel	Aventis Pasteur, Ltd	0
Td¹ (Tetanus and diphtheria toxoids)	None	Aventis Pasteur, Inc.	25
	Decavac	Aventis Pasteur, Inc.	= 0.3
	None	Aventis Pasteur, Ltd	0
	None	Mass Public Health	8.3
DTaP-Hib (Diphtheria and tetanus toxoids with acellular pertussis combined with Haemophilus influenzae type b)	TriHIBit²	Aventis Pasteur	≤0.3
Hib (Haemophilus influenzae type b)	ActHIB/OmniHib	Aventis Pasteur, SA	0
	HibTITER (Single dose)	Wyeth-Lederle	0
	PedvaxHIB liquid	Merck	0
Hib/HepB (Haemophilus influenzae type b combined with Hepatitis B )	COMVAX	Merck	0
Hep B (Hepatitis B) (pediatric formulation)	Engerix B	Glaxo-SmithKline	<0.5
Hep B (Hepatitis B) (pediatric formulation)	Recombivax HB	Merck	0
Influenza	Fluzone³	Aventis Pasteur, Inc.	12.5
	Fluzone	Aventis Pasteur, Inc.	≤0.5ug/
	(Preservative Free)		0.25mL dose
Pneumococcal	Prevnar (pneumoconjugate)	Wyeth	0
IPV (Inactivated polio vaccine)	IPOL	Aventis Pasteur, SA	0
IPV (Inactivated polio vaccine)	Poliovax	Aventis Pasteur, Ltd.	0
MMR (Measles, mumps, and rubella)	MMR-II	Merck	0
Varicella	Varivax	Merck	0
¹Licensed for persons 7 years of age and older. ²For use in children 15 to 18 months of age. ³Influenza vaccine is recommended for children 6-23 months of age. MMWR (2004) 52:1-4; MMWR (2004) 53:1-3.

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TABLE C-2 Mercury Content from Thimerosal in the Currently Licensed Vaccines That Are Recommended for Some Children in the United States, April 2004

Vaccine	Brand Name	Manufacturer	Hg [μg/dose]
DT (Diphtheria and tetanus toxoids)	All Products	Aventis Pasteur, Inc. (single dose)	0.3
		Aventis Pasteur, Inc. (multi-dose)	25
		Aventis Pasteur, Ltd*	25
TT (Tetanus Toxoid)	All Products	Aventis Pasteur, Inc.	25
Pneumococcal Polysaccharide	Pneumovax 23	Merck	0
Hepatitis A	Havrix	Glaxo-SmithKline	0
Hepatitis A	Vaqta	Merck	0
Influenza	Fluzone¹	Aventis Pasteur, Inc.	25
	Fluzone (Preservative free)	Aventis Pasteur, Inc.	≤1 μg/0.5 mL dose or ≤0.5 μg/ 0.25 mL dose
	Fluvirin	Evans	25
	Fluvirin	Evans	<1 μg
Influenza, Live	FluMist	MedImmune	0
*Not available in the United States. ¹Children under 3 years of age received half of a vaccine dose (0.25 mL or 12.5 μg mercury/dose).

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TABLE C-3 Mercury Content from Thimerosal in Other Licensed Vaccines in the United States, April 2004

Vaccine	Brand Name	Manufacturer	Hg [μg/dose]
Anthrax	BioThrax	BioPort Corporation	0
Smallpox	Dryvax	Wyeth	0
BCG*		Organon Tecknika	0
BCG*	Mycobax	Aventis Pasteur, Ltd	0
Hepatitis A-Hepatitis B	Twinrix	Glaxo-SmithKline	<1 μg
Hepatitis B	Engerix B (adult formulation)	Glaxo-SmithKline	< 0.5
	Recombivax HB (adult formulation)	Merck	25
	Recombivax HB (adult formulation)	Merck	0
Lyme*	LYMErix	Glaxo-SmithKline	0
Meningococcal¹	Menomune A, C, AC and A/C/Y/W-135	Aventis Pasteur, Inc. (multidose)	25
Meningococcal¹		Single dose	0
Rabies	IMOVAX	Aventis Pasteur SA	0
Rabies	Rabavert	Chiron Behring	0
Typhoid Fever	Typhim Vi	Aventis Pasteur SA	0
Typhoid Fever	Vivotif Berna	Berna Biotech, Ltd.	0
Yellow Fever	YF-VAX	Aventis Pasteur, Inc.	0
Japanese Encephalitis Vaccine	JE-VAX	Aventis Pasteur, Inc.	35
Not available in the United States. ¹Menomune A/C/Y/W-135, a thimerosal-containing vaccine, is not indicated for infants and children younger than 2 years of age except as short-term protection of infants 3 months and older against Group A. (Physician’s Desk Reference*, 2001).

Immunization Safety Review: Vaccines and Autism (2004)

Chapter: Appendix C: Thimerosal Content in Licensed Vaccines (Adapted from FDA, 2003, 2004)

Appendix C
Thimerosal Content in Licensed Vaccines (Adapted from FDA, 2003, 2004)

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Immunization Safety Review: Vaccines and Autism (2004)

Chapter: Appendix C: Thimerosal Content in Licensed Vaccines (Adapted from FDA, 2003, 2004)

Appendix C Thimerosal Content in Licensed Vaccines (Adapted from FDA, 2003, 2004)

Appendix C
Thimerosal Content in Licensed Vaccines (Adapted from FDA, 2003, 2004)