| ACA | Patient Protection and Affordable Care Act |
| ACOSOG | American College of Surgeons Oncology Group |
| ACRIN | American College of Radiology Imaging Network |
| AHRQ | Agency for Healthcare Research and Quality |
| AIM | Annotation and Image Markup |
| ARPANET | Advanced Research Projects Agency Network |
| ARRA | American Recovery and Reinvestment Act |
| ASCO | American Society of Clinical Oncology |
| ATM | automated teller machine |
| BRIDG | Biomedical Research Integrated Domain Group |
| caBIG® | Cancer Biomedical Informatics Grid |
| CALGB | Cancer and Leukemia Group B |
| CARE | Comprehensive Accrual REsource |
| CDC | Centers for Disease Control and Prevention |
| CER | comparative effectiveness research |
| CTEP | Cancer Therapy and Evaluation Program |
| CTMS | clinical trial management system |
| CTSA | Clinical Translational Science Award |
| CTSU | Cancer Trials Support Unit |
| DNA | deoxyribonucleic acid |
| ECOG | Eastern Cooperative Oncology Group |
| EHR | electronic health record |
| ELISA | enzyme-linked immunosorbent assay |
| eMAR | electronic medication administration record |
| ER | estrogen receptor |
| FBI | Federal Bureau of Investigation |
| FDA | Food and Drug Administration |
| GCP | Good Clinical Practice |
| GEO | Gene Expression Omnibus |
| GPS | global positioning system |
| HbA1c | hemoglobin A1c |
| HER2 | human epidermal growth factor receptor 2 |
| HHS | U.S. Department of Health and Human Services |
| HIPAA | Health Insurance Portability and Accountability Act |
| HITECH | Health Information Technology for Economic and Clinical Health Act |
| i2b2 | Informatics for Integrating Biology and the Bedside |
| IOM | Institute of Medicine |
| iPS cells | induced pluripotent stem cells |
| IRB | institutional review board |
| IT | information technology |
| NCBI | National Center for Biotechnology Information |
| NCCN | National Comprehensive Cancer Network |
| NCCTG | North Central Cancer Treatment Group |
| NCI | National Cancer Institute |
| NHD | Optum Natural History of Disease |
| NIH | National Institutes of Health |
| NIMH | National Institute of Mental Health |
| NSABP | National Surgical Adjuvant Breast and Bowel Project |
| NSF | National Science Foundation |
| OCRe | Ontology of Clinical Research |
| ONC | Office of the National Coordinator for Health Information Technology |
| QOPI | Quality Oncology Practice Initiative |
| P4 | predictive, preventive, personalized, and participatory |
| PACeR | Partnership to Advance Clinical electronic Research |
| PCAST | President’s Council of Advisors on Science and Technology |
| PCORI | Patient-Centered Outcomes Research Institute |
| RCT | randomized, controlled trial |
| REDCap | Research Electronic Data Capture |
| RNA | ribonucleic acid |
| RTOG | Radiation Therapy Oncology Group |
| SEER | Surveillance, Epidemiology, and End Results Program |
| SHARP | Strategic HIT Advanced Resource Projects |
| siRNA | small interfering RNA |
| SPARKS | Synergistic Patient and Research Knowledge Systems |
| SRM | selected reaction monitoring |
| SWOG | formerly the Southwest Oncology Group |
| TCGA | The Cancer Genome Atlas |
| TGen | Translational Genomics Research Institute |
| UNOS | United Network for Organ Sharing |