| AAAS | American Association for the Advancement of Science |
| ABL | Airborne Laser Laboratory |
| AC | alternating current |
| ACF | anisotropic conducive film |
| AFOSR | Air Force Office of Scientific Research |
| AIDS | acquired immune deficiency syndrome |
| AIP | American Institute of Physics |
| ALTB | Airborne Laser Test Bed |
| ALTSim | alternative liquid fuels simulation model |
| AMD | age-related macular degeneration |
| AMO | atomic, molecular, optics |
| AO | adaptive optics |
| APD | avalanche photodiode |
| APPLE | Adaptive Photonic Phase Locked Elements (program) |
| APRS | advanced plasma reactive sputtering |
| APS | American Physical Society |
| ARGUS-IS | Autonomous Real-Time Ground Ubiquitous Surveillance-Imaging System |
| ARO | Army Research Office |
| ARPA | Advanced Research Projects Agency |
| ASML | Advanced Semiconductor Materials Lithography (Dutch company) |
| ATL | advanced tactical laser |
| ATP | Advanced Technology Program |
| BER | bit error rate |
| BRCA1 | breast cancer susceptibility gene 1 |
| BRCA2 | breast cancer susceptibility gene 2 |
| CAD | computer-aided design |
| CCD | charge-coupled device |
| CCT | correlated color temperature |
| Ce:YAG | cerium-doped yttrium aluminum garnet |
| CIA | Central Intelligence Agency |
| CIGS | copper indium gallium selenide |
| CLEO | Conference on Lasers and Electro-Optics |
| CMOS | complementary metal oxide semiconductor |
| CMU | Carnegie Mellon University |
| CNC | computer numerically controlled |
| CO | carbon monoxide |
| CO2 | carbon dioxide |
| COIL | chemical oxygen iodine laser |
| CPV | concentrating photovoltaic |
| CRI | Color Rendering Index |
| CSP | concentrating solar power |
| CT | computed tomography |
| CTE | coefficient of thermal expansion |
| CVD | chemical vapor deposition |
| DARPA | Defense Advanced Research Projects Agency |
| DAS | distributed acoustic sensing |
| DC | direct current |
| DHS | Department of Homeland Security |
| DLP | digital light processor |
| DNA | deoxyribonucleic acid |
| DOD | Department of Defense |
| DOE | Department of Energy |
| DPP | discharge-produced plasma |
| DPSK | differential phase-shift keying |
| DQPSK | differential quadrature phase-shift keying |
| DR | diabetic retinopathy |
| DSO | Defense Sciences Office |
| DSP | digital signal processing |
| ECE | energy critical element |
| ECOC | European Conference on Optical Communication |
| EDFA | erbium-doped fiber amplifier |
| EE | electrical engineering |
| EECS | electrical engineering and computer science |
| EERE | Energy Efficiency and Renewable Energy |
| EM | electromagnetic |
| EO | electrooptical |
| EPMD | Electronics, Photonics, and Magnetic Devices (Division, NSF) |
| ER | emergency room |
| EU | European Union |
| EUV | extreme ultraviolet |
| FACS | flow cytometry |
| FDI | foreign direct investment |
| flops | floating point operations per second |
| FOV | field of view |
| FPA | focal plane array |
| FPD | flat panel display |
| FTTH | fiber to the home |
| FY | fiscal year |
| GaAs | gallium arsenide |
| GFP | green fluorescent protein |
| GFR | glomerular filtration rate |
| GHz | gigahertz |
| GPS | Global Positioning System |
| GPT | general-purpose technology |
| HALOE | halogen occultation experiment |
| HAMR | heat-assisted magnetic recording |
| HDTV | high-definition television |
| HEL JTO | High Energy Laser-Joint Technology Office |
| HELLADS | High Energy Liquid Laser Area Defense System |
| HGP | Human Genome Project |
| HIV | human immunodeficiency virus |
| Ho:YAG | holmium-doped yttrium aluminum garnet |
| HT | high-throughput |
| IAD | ion-assisted deposition |
| IBS | ion beam sputtering |
| IC | integrated circuit |
| IEA | International Energy Agency |
| IEEE | Institute of Electrical and Electronics Engineers |
| IGZO | indium gallium zinc oxide |
| InAs | indium arsenide |
| InP | indium phosphide |
| IP | intellectual property |
| IPO | initial public offering |
| IQE | internal quantum efficiency |
| IR | infrared |
| IRR | internal rate of return |
| IRS | Internal Revenue Service |
| ISAT | Information Science and Technology Board (DARPA) |
| ISIS | Integrated Sensor Is Structure (program) |
| ISR | intelligence, surveillance, and reconnaissance |
| IT | information technology |
| ITAR | International Traffic in Arms Regulations |
| ITO | indium tin oxide |
| ITRS | International Technology Roadmap for Semiconductors |
| IWGN | Interagency Working Group of Nanotechnology |
| JBSDS | Joint Biological Stand-off Detection System |
| JHPSSL | Joint High Power Solid State Laser |
| JTEC | Japanese Technology Evaluation Center |
| JTO | Joint Technology Office |
| LACOSTE | Large Area Coverage Optical Search-while-Track and Engage |
| LADAR | laser radar |
| LAN | local area network |
| LASIK | laser-assisted in situ keratomileusis |
| LCD | liquid-crystal display |
| LCM | laser capture micro dissection |
| LCOE | levelized cost of energy |
| LCoS | liquid crystal on silicon |
| LED | light-emitting diode |
| LELE | litho-etch-litho-etch |
| LENS™ | Laser Engineered Net Shaping |
| LEOS | Lasers and Electro-Optics Society |
| LFLE | litho-freezing-litho-etch |
| LIA | Laser Institute of America |
| LIDAR | light detection and ranging |
| LIGO | Laser Interferometer Gravitational-Wave Observatory |
| LISA | Laser Interferometer Space Antenna |
| LLE | litho-litho-etch |
| LOCI | Ladar and Optical Communications Institute |
| LP | linear polarization |
| LPP | laser-produced plasma |
| MANPADS | man portable air defense systems |
| MDR | multi-drug resistant |
| MEMS | microelectromechanical system |
| MIMO | multiple-input, multiple-output |
| MIPS | millions of instructions per second |
| MIT | Massachusetts Institute of Technology |
| MLD | Maritime Laser Demonstrator |
| MOCVD | metal-organic chemical vapor deposition |
| MONET | multiwavelength optical networking |
| MOPA | master oscillator power amplifier |
| MOS | metal oxide semiconductor |
| MRF | magnetorheological finishing |
| MRI | magnetic resonance imaging |
| mRNA | messenger ribonucleic acid |
| MTHEL | Mobile Tactical High Energy Laser |
| MTO | Microsystems Technology Office |
| MWIR | mid-wavelength infrared |
| NA | numerical aperture |
| NAE | National Academy of Engineering |
| NAICS | North American Industry Classification System |
| NAS | National Academy of Sciences |
| NASA | National Aeronautics and Space Administration |
| NATO | North Atlantic Treaty Organization |
| NCI | National Cancer Institute |
| Nd:YAG | neodymium-doped yttrium aluminum garnet |
| NEI | National Eye Institute |
| NHLBI | National Heart, Lung, and Blood Institute |
| NIH | National Institutes of Health |
| NIST | National Institute of Standards and Technology |
| NMMB | National Materials and Manufacturing Board |
| NNAP | National Nanotechnology Advisory Panel |
| NNI | National Nanotechnology Initiative |
| NRC | National Research Council |
| NRDA | Nanotechnology Research and Development Act |
| NREL | National Renewable Energy Laboratory |
| NSE | nanoscale science and engineering |
| NSET | Nanoscale Science, Engineering, and Technology |
| NSF | National Science Foundation |
| NVCA | National Venture Capital Association |
| OADM | optical add/drop multiplexer |
| OAI | off-axis illumination |
| OCT | optical coherence tomography |
| OFC | Optical Fiber Communications Conference |
| OFDM | orthogonal frequency division multiplexing |
| OIDA | Optoelectronics Industry Development Association |
| OITDA | Optoelectronics Industry and Technology Development Association |
| OLED | organic light-emitting diode |
| ONR | Office of Naval Research |
| OOK | on-off keying |
| OPC | optical proximity correction |
| OSA | Optical Society of America |
| OSE | optical science and engineering |
| OSTP | Office of Science and Technology Policy |
| PC | personal computer |
| PCAST | President’s Council of Advisors on Science and Technology |
| PCF | photonic-crystal fiber |
| PCR | polymerase chain reaction |
| PDM | polarization division multiplexed |
| PhC | photonic crystal |
| PIC | photonic integrated circuit |
| PISA | Program for International Student Assessment |
| PON | passive optical network |
| PRK | photorefractive keratectomy |
| PSA | prostate-specific antigen |
| PSK | phase-shift keying |
| PSM | phase-shifting masks |
| PV | photovoltaic |
| PVOCT | phase variance optical coherence tomography |
| QAM | quadrature-amplitude-modulation |
| QCMC | quantum communication, measurement, and computing |
| QCSE | Quantum-Confined Stark Effect |
| QD | quantum dot |
| QELS | quantum electronics and laser science |
| QKD | quantum key distribution |
| QPSK | quadrature-phase-shift-keying |
| QW | quantum well |
| R&D | research and development |
| RCA | Radio Corporation of America |
| RET | resolution enhancement technology |
| RF | radio frequency |
| RGB | red green blue |
| RIN | relative intensity noise |
| RMS | root mean square |
| RNA | ribonucleic acid |
| ROADM | reconfigurable optical add/drop multiplexer |
| RT-PCR | real-time polymerase chain reaction |
| S&T | science and technology |
| SAIL | Synthetic Aperture Imaging Ladar |
| SAM | Solar Advisor Model |
| SAR | synthetic aperture radar |
| SBIR | Small Business Innovation Research |
| SBS | synthesis-based sequencing |
| SDM | space division multiplexing |
| SEMATECH | Semiconductor Manufacturing Technology |
| SEMI | Semiconductor Equipment and Materials International |
| SIC | Standard Industrial Classification |
| SIM | sensing, imaging, and metrology |
| SLS | selective laser sintering |
| SOP | state of polarization |
| SPDT | single-point diamond turning |
| SPIE | International Society for Optics and Photonics |
| SRC | Semiconductor Research Corporation |
| SS | solid state |
| STEM | science, technology, engineering, and mathematics |
| SWaP | size, weight, and power |
| TFPV | thin-film photovoltaics |
| TFT | thin-film transistor |
| THEL | Tactical High Energy Laser |
| TIP | Technology Innovation Program |
| UAV | unmanned aerial vehicle |
| UNCTAD | United Nations Conference on Trade and Development |
| UNESCO | United Nations Educational, Scientific, and Cultural Organization |
| UNIDO | United Nations Industrial Development Organization |
| USPTO | U.S. Patent and Trademark Office |
| UV | ultraviolet |
| VCSEL | vertical cavity surface emitting laser |
| WDM | wavelength division multiplexing |
| YAG | yttrium aluminum garnet |