| CMEC | condensed matter at extreme conditions |
| CMMR | Chemical and Metallurgical Research Replacement |
| DARHT | Dual-Axis Radiographic Hydro-Test Facility |
| DNFSB | Defense Nuclear Facilities Safety Board |
| DOD | Department of Defense |
| DOE | Department of Energy |
| EOS | equation of state |
| ES&H | Environmental Health and Safety |
| FFRDC | federally funded research and development center |
| FTE | full-time equivalent |
| FY | fiscal year |
| HE | high explosive |
| HEDS | high-energy-density science |
| ICF | inertial confinement fusion |
| IMC | integrated modeling codes |
| LANL | Los Alamos National Laboratory |
| LDRD | Laboratory Directed Research and Development |
| LEP | Life Extension Program |
| LLNL | Lawrence Livermore National Laboratory |
| M&S | modeling and simulation |
| NIC | National Ignition Campaign |
| NIF | National Ignition Facility |
| NNSA | National Nuclear Security Administration |
| NRC | National Research Council |
| NW | nuclear weapons |
| ORNL | Oak Ridge National Laboratory |
| PF-4 | LANL plutonium facility |
| R&D | research and development |
| S&E | science and engineering |
| S&T | science and technology |
| SNL | Sandia National Laboratories |
| SPR | Sandia Pulsed Reactor |
| SSP | Stockpile Stewardship Program |
| TRL | technology readiness level |
| UGT | underground test data |
| UQ | uncertainty quantification |
| V&V | verification and validation |
| WFO | work for others |
| Z | Z Pulsed Power Facility |