First Name
Last Name
Email (required)
I agree to receive emails from the National Academies (required)

We respect your privacy and will never share your information.

Search this publication

Front Matter i-xiv
Chapter 1 The Secrets of Life: A Mathematician's Introduction to Molecular Biology 1-1
BIOCHEMISTRY 2-4
CLASSICAL GENETICS 5-6
MOLECULAR BIOLOGY 7-12
THE RECOMBINANT DNA REVOLUTION 13-15
MOLECULAR GENETICS IN THE 1990S 16-17
THE HUMAN GENOME PROJECT 18-21
COMING ATTRACTIONS 22-23
REFERENCES 24-24
Chapter 2 Mapping Heredity: Using Probabilistic Models and Algorithms to Map Genes and Genomes 25-26
The Concept of Genetic Maps 27-29
Challenges of Genetic Mapping: Human Families and Complex Traits 30-33
MAXIMUM LIKELIHOOD ESTIMATION 34-34
Efficient Algorithms 35-36
Excursion: Susceptibility to Colon Cancer in Mice and the Large Deviation Theory of Diffusion Processes 37-41
Assembling Physical Maps by "Fingerprinting" Random Clones 42-46
Excursion: Designing a Strategy to Map the Human Genome 47-50
CONCLUSION 51-53
REFERENCES 54-55
Chapter 3 Seeing Conserved Signals: Using Algorithms to Detect Similarities between Biosequences 56-57
FINDING GLOBAL SIMILARITIES 58-58
Visualizing Alignments: Edit Graphs 59-59
The Basic Dynamic Programming Algorithm 60-64
FINDING LOCAL SIMILARITIES 65-69
Variations in Gap Cost Penalties 70-71
The Duality Between Similarity and Difference Measures 72-72
Aligning More Than Two Sequences at a Time 73-75
K-Best Alignments 76-77
Approximate Pattern Matching 78-78
Parallel Computing 79-80
COMPARING ONE SEQUENCE AGAINST A DATABASE 81-81
Heuristic Algorithms 82-83
Sublinear Similarity Searches 84-85
OPEN PROBLEMS 86-87
REFERENCES 88-89
Chapter 4 Hearing Distant Echoes: Using Extremal Statistics to Probe Evolutionary Origins 90-93
Sequence Alignment 94-94
Alignment Given 95-95
Alignment Unknown 96-98
Alignment Given 99-104
Alignment Unknown 105-105
APPLICATION TO RNA EVOLUTION 106-107
TWO BEHAVIORS SUFFICE 108-109
RNA EVOLUTION REVISITED 110-111
REFERENCES 112-113
Chapter 5 Calibrating the Clock: Using Stochastic Processes to Measure the Rate of Evolution 114-116
OVERVIEW 117-118
THE COALESCENT AND MUTATION 119-121
The Ewens Sampling Formula 122-123
Top-down 124-124
Bottom-up 125-126
The Infinitely-Many-Sites Model 127-129
K-Allele Models 130-131
The Finitely-Many-Sites Models 132-135
Approximations for the Ewens Sampling Formula 136-138
Combinatorial Assemblies 139-141
Other Combinatorial Structures 142-143
The Large Components 144-144
WHERE TO NEXT? 145-145
Likelihood Methods 146-147
Discussion 148-148
General-Purpose References 149-149
Detailed References 150-152
Chapter 6 Winding the Double Helix: Using Geometry, Topology, and Mechanics of DNA 153-154
DNA GEOMETRY AND TOPOLOGY: LINKING, TWISTING, AND WRITHING 155-162
APPLICATIONS TO DNA TOPOISOMERASE REACTIONS 163-165
DNA ON PROTEIN COMPLEXES 166-166
THE SURFACE LINKING NUMBER 167-170
THE WINDING NUMBER AND HELICAL REPEAT 171-172
RELATIONSHIP BETWEEN LINKING, SURFACE LINKING, AND WINDING 173-173
APPLICATION TO THE STUDY OF THE MINICHROMOSOME 174-176
REFERENCES 177-178
Chapter 7 Unwinding the Double Helix: Using Differential Mechanics to Probe Conformational Changes... 179-180
DNA SUPERHELICITY - MATHEMATICS AND BIOLOGY 181-183
STATEMENT OF THE PROBLEM 184-185
THE ENERGETICS OF A STATE 186-186
ANALYSIS OF SUPERHELICAL EQUILIBRIA 187-191
Evaluation of Free-Energy Parameters 192-193
Accuracy of the Calculated Results 194-194
APPLYING THE METHOD TO STUDY INTERESTING GENES 195-198
DISCUSSION AND OPEN PROBLEMS 199-199
REFERENCES 200-201
Chapter 8 Lifting the Curtain: Using Topology to Probe the Hidden Action of Enzymes 202-202
THE TOPOLOGY OF DNA 203-206
SITE-SPECIFIC RECOMBINATION 207-211
TOPOLOGICAL TOOLS FOR DNA ANALYSIS 212-221
THE TANGLE MODEL FOR SITE-SPECIFIC RECOMBINATION 222-224
THE TOPOLOGY OF TN3 RESOLVASE 225-229
SOME UNSOLVED PROBLEMS 230-231
Application of Geometry and Topology to Biology 232-232
REFERENCES 233-235
Chapter 9 Folding the Sheets: Using Computational Methods to Predict the Structure of Proteins 236-236
A PRIMER ON PROTEIN STRUCTURE 237-240
BASIC INSIGHTS ABOUT PROTEIN STRUCTURE 241-247
THREADING METHODS 248-253
PREDICTING HIV PROTEASE STRUCTURE:AN EXCURSION 254-254
HIERARCHICAL APPROACHES 255-264
PREDICTING MYOGLOBIN STRUCTURE:AN EXCURSION 265-265
ACKNOWLEDGMENTS 266-266
REFERENCES 267-271
Appendix - Chapter Authors 272-276
Index 277-285

Log In

Former MyNAP users: You'll need to reset your password on your first login to MyAcademies. Click "Forgot password" below to receive a reset link via email. Having trouble? Visit our FAQ page to contact support.

Members of the National Academy of Sciences, National Academy of Engineering, or National Academy of Medicine should log in through their respective Academy portals.

Email (required)
Password (required)

Don't have an account?

Register

Email (required)
New password (required)
Retype password (required) Password must be at least 8 characters
I agree to receive emails from the National Academies
I accept the terms of use
terms of use

Download as a Guest

While logged on as a guest, you can download any of our free PDFs on nationalacademies.org . You will remain logged in until you close your browser.

Email (required)
Yes, send me emails when similar titles are published
Yes, I accept the terms of use
terms of use

Thank You

Thank you for creating a MyAcademies account!

Enjoy free access to thousands of National Academies' publications, a 10% discount off every purchase, and build your personal library.

Forgot Password

Enter the email address for your MyAcademies (formerly MyNAP) account to receive password reset instructions.

Email (required)

Reset Requested

We sent password reset instructions to your email . Follow the link in that email to create a new password. Didn't receive it? Check your spam folder or contact us for assistance.

Reset Password

New password (required)
Retype password (required) Password must be at least 8 characters

Reset Password

Your password has been reset.

Verify email

Verify Your Email Address

We sent a verification link to your email. Please check your inbox (and spam folder) and follow the link to verify your email address. If you did not receive the email, you can request a new verification link below

Calculating the Secrets of Life: Contributions of the Mathematical Sciences to Molecular Biology (1995)

Chapter: Likelihood Methods

My Academies

Calculating the Secrets of Life: Contributions of the Mathematical Sciences to Molecular Biology (1995)

Chapter: Likelihood Methods