Review of California's Risk-Assessment Process for Pesticides (2015)
Chapter: Appendix D: Pesticide Toxicity Estimates of the Department of Pesticide Regulation and the US Environmental Protection Agency Used to Generate Bottom Histogram of Figure 3-3
Toxicity Estimates from Pesticide Assessments Completed by DPR in 2004–2014 and from EPA
| Pesticide | Toxicity Estimatesa | EPA:DPR Ratiob | |
| DPR NOEL, mg/kg-day | EPA NOEL, mg/kg-day | ||
| 2010–2014 | |||
| SIMAZINE (2014) | |||
Acute, dietary | 5 | 30 | 6 |
Acute, nondietary | 5 | 6.25 | 1.3 |
Subchronic | 0.56 | 1.18 | 2.1 |
Chronic | 0.52 | 1.18 | 2.3 |
Carcinogen (threshold) | 2.9 | No | DPR higher potency |
| PHOSPHINE (2013) | |||
Acute, inhalation | 5 ppm | 5 ppm | 1 |
Subchronic, inhalation | 1 | 3 | 3 |
Chronic, inhalation | 1 | 3 | 3 |
Carcinogen | No | No | Same |
| CARBARYL (2012) | |||
Acute, oral | 1 | 1.1 | 1.1 |
Acute, dermal | 20 | 86 | 4.3 |
Acute, inhalation | 1 | 1.1 | 1.1 |
Carcinogen (Q*) | 9.72 × 10-3 | 8.75 × 10-4 | DPR 11× higher potency |
| PROPARGITE (2012) | |||
Acute, oral | 2 | 8 | 4 |
Acute, inhalation | 5 | 5 | 1 |
Subchronic, dermal | 1 | 4 | 4 |
Subchronic, inhalation | 0.5 | 5 | 10 |
Chronic, oral | 3.8 | 4 | 1.1 |
Carcinogen (Q*) | 2.6 × 10-2 | 3.3 × 10-2 | Same (0.5–2.0) |
| METHYL PARATHION (2010) | |||
Acute, dermal | 0.025 | 0.1 | 4 |
Subchronic, inhalation | 0.03 | 0.11 | 3.7 |
Subchronic, dermal | 0.03 | 0.1 | 3.3 |
Chronic | 0.02 | 0.02 | 1 |
Carcinogen | No | No | Same |
| 2004–2009 | |||
| ENDOSULFAN (2008) | |||
Acute, oral | 0.7 | 1.5 | 2.1 |
Acute, dermal | 0.7 | 1.25 | 1.8 |
Acute, inhalation | 0.194 | 0.2 | 1 |
Subchronic, dermal | 1.18 | 1.25 | 1.1 |
Subchronic, inhalation | 0.194 | 0.2 | 1 |
Chronic, oral | 0.57 | 0.6 | 1 |
Carcinogen | No | No | Same |
| METHIDATHION (2007) | |||
Acute, oral | 0.18 | 0.2 | 1.1 |
Acute, dermal | 0.18 | 20 | 111 |
Subchronic | 0.18 | 0.2 | 1.1 |
Chronic | 0.15 | 0.15 | 1 |
Carcinogen | 0.53 | No | DPR higher potency |
| CARBOFURAN (2006) | |||
Acute | 0.01 | 0.08 | 8 |
Subchronic | 0.1 | 0.08 | 0.8 |
Chronic | 0.1 | 0.025 (300) | 0.083 |
Carcinogen | No | No | Same |
| METAM SODIUM (2004) | |||
Acute | 1 | 4.22 | 4.2 |
Subchronic | 0.2 | 0.1 | 0.5 |
Chronic | 0.1 | 0.1 | 1 |
Carcinogen (Q*) | 1.85 × 10-1 | 1.98 × 10-1 | Same (0.5–2.0) |
| AZINPHOSMETHYL (2004) | |||
Acute, oral/dermal | 0.75 (10) | 1 | 0.13 |
Subchronic, oral | 0.25 (30) | 0.149 | 0.18 |
Chronic | 0.15 (30) | 0.149 | 0.3 |
Carcinogen (Q*) | No | No | Same |
| METHAMIDIPHOS (2001/2007) | |||
Acute, oral | 0.3 | 0.3 (300) | 0.33 |
Acute, dermal | 3 | 0.75 | 0.25 |
Subchronic, dermal | 0.75 | 0.75 | 1 |
Chronic, oral | 0.02 | 0.03 (300) | 0.5 |
Carcinogen (Q*) | No | No | Same |
aValues obtained from G. Patterson, California Department of Pesticide Regulation, personal communication, July 1, 2014. Target MOEs were 100 except where noted in parentheses.
bThe ratio includes allowance for MOEs that differ from 100 (NOEL/MOE [EPA] ÷ NOEL/MOE [DPR]). Abbreviations: DPR, Department of Pesticide Regulation; EPA, US Environmental Protection Agency; MOE, margin of exposure; NOEL, no-observed-effect level; Q*, cancer potency factor.
