| AHRQ | Agency for Healthcare Research and Quality |
| AMIA | American Medical Informatics Association |
| ANSI | American National Standards Institute |
| ARRA | American Recovery and Reinvestment Act |
| BHI | biomedical and health informatics |
| BOLT | Broad Operational Language Translation |
| BSIMM | Building Security in Maturity Model |
| Caltech | California Institute of Technology |
| CDC | Centers for Disease Control and Prevention |
| CIF | Common Industry Format |
| CPS | cyberphysical systems |
| CPS PWG | CPS Public Working Group |
| CVE | Common Vulnerabilities and Exposures |
| CWE | Common Weakness Enumeration |
| DARPA | Defense Advanced Research Projects Agency |
| DNA | deoxyribonucleic acid |
| EHR | electronic health record |
| FBI | Federal Bureau of Investigation |
| FDA | Food and Drug Administration |
| GALE | Global Autonomous Language Exploitation |
| HICT | health information and communication technology |
| HITECH | Health Information Technology for Economic and Clinical Health |
| IAD | Information Access Division |
| ITL | Information Technology Laboratory |
| IEEE | Institute of Electrical and Electronics Engineers |
| IoT | Internet of Things |
| IPA | Intergovernmental Personnel Act |
| IRB | Institutional Review Board |
| IREX | Interoperable Iris Exchange |
| ISO | International Organization for Standardization |
| MATLAB® | matrix laboratory |
| MetricsMaTr | Metrics for Machine Translation Challenge |
| MIT | Massachusetts Institute of Technology |
| MT | machine translation |
| NIH | National Institutes of Health |
| NIST | National Institute of Standards and Technology |
| NLM | National Library of Medicine |
| NRC | National Research Council |
| ONC | Office of the National Coordinator |
| PCORI | Patient-Centered Outcomes Research Institute |
| PRET | Precision Timed |
| SDL | Security Development Lifecycle |
| SDO | standards development organization |
| SED | Statistical Engineering Division |
| SQuaRE | Software Product Quality Requirements and Evaluation |
| SRM | standard reference material |
| SSA | software analysis |
| SSD | Software and Systems Division |
| TREC | Text Retrieval Conference |
| TRECVID | TREC for Video |