The Children's Vaccine Initiative: Achieving the Vision (1993)
Chapter: Appendix H: Historical Record of Vaccine Product License Holders in the United States
H
Historical Record of Vaccine Product License Holders in the United States
TABLE H-1 Vaccine Product License Holders in the United States
|
Company and Vaccine or Product |
Date of License |
Date of Revocation |
|
Bionetics Research Inc.a |
|
|
|
BCG vaccine |
05/29/1987 |
06/21/1989 |
|
Connaught Laboratories, Inc.b |
|
|
|
BCG live |
05/21/1990 |
|
|
BCG vaccine |
03/31/1967 |
05/21/1990 |
|
Diphtheria & tetanus toxoids & acellular pertussis vaccine, adsorbed |
09/20/1992 |
|
|
Diphtheria & tetanus toxoids & pertussis vaccine (DTP) |
01/03/1978 |
11/29/1982 |
|
Diphtheria & tetanus toxoids, & pertussis vaccine, adsorbed |
01/03/1978 |
|
|
Diphtheria & tetanus toxoids adsorbed |
09/18/1984 |
|
|
Diphtheria toxoid |
01/03/1978 |
|
|
Haemophilus influenzae type b Conjugate |
|
|
|
(diphtheria toxoid conjugate) |
12/22/1987 |
|
|
Company and Vaccine or Product |
Date of License |
Date of Revocation |
|
Haemophilus influenzae type b polysaccharide |
12/20/1985 |
|
|
Influenza |
01/03/1978 |
|
|
Meningococcal polysaccharide group A |
01/03/1978 |
|
|
Meningococcal polysaccharide group C |
01/03/1978 |
|
|
Meningococcal polysaccharide vaccine, groups A and C combined |
01/03/1978 |
|
|
Meningococcal polysaccharide vaccine, groups A, C, Y, W135 combined |
11/23/1981 |
|
|
Pertussis vaccine |
01/03/1978 |
|
|
Poliomyelitis virus, inactivated human diploid cell |
11/20/1987 |
|
|
Poliomyelitis virus, inactivated monkey kidney cell |
01/24/1963 |
|
|
Rabies vaccine |
12/27/1991 |
|
|
Smallpox vaccine |
01/03/1978 |
|
|
Tetanus toxoid |
01/03/1978 |
|
|
Tetanus toxoid, adsorbed |
01/03/1978 |
|
|
Tetanus & diphtheria toxoids adsorbed (for adult use) |
01/03/1978 |
|
|
Yellow fever |
01/03/1978 |
|
|
Connaught Laboratories, Limitedb |
|
|
|
Diphtheria toxoid |
04/28/1928 |
05/27/1977 |
|
Tetanus toxoid |
01/14/1943 |
|
|
Small pox vaccine |
10/23/1967 |
04/01/1980 |
|
Dow Chemical Companya |
|
|
|
Diphtheria & tetanus toxoids & pertussis vaccine adsorbed |
09/11/1970 |
06/07/1977 |
|
Diphtheria toxoid |
09/18/1934 |
06/07/1977 |
|
DT, adsorbed |
09/11/1970 |
06/07/1977 |
|
DP, adsorbed |
09/11/1970 |
06/07/1977 |
|
Measles, live |
02/05/1965 |
06/07/1978 |
|
Measles and rubella, live |
04/17/1974 |
06/21/1978 |
|
Measles, mumps, rubella, live |
04/17/1974 |
06/21/1978 |
|
Mumps virus vaccine, live |
04/17/1974 |
06/21/1978 |
|
Pertussis vaccine |
10/01/1932 |
06/07/1977 |
|
Rubella virus, live |
03/01/1974 |
06/21/1978 |
|
Tetanus toxoid |
08/01/1936 |
06/07/1977 |
|
Tetanus toxoid, adsorbed |
09/01/1970 |
06/07/1977 |
|
Eli Lilly and Companya |
|
|
|
Cholera |
10/31/1917 |
06/07/1979 |
|
Diphtheria & tetanus toxoids |
09/09/1970 |
06/07/1979 |
|
Company and Vaccine or Product |
Date of License |
Date of Revocation |
|
Diphtheria & tetanus toxoids, and pertussis vaccine adsorbed |
09/09/1970 |
12/02/1985 |
|
DT, adsorbed |
09/09/1970 |
06/07/1979 |
|
Influenza |
11/09/1945 |
04/11/1977 |
|
Mumps vaccine |
01/27/1950 |
04/11/1977 |
|
Pertussis vaccine |
03/31/1915 |
03/07/1978 |
|
Rabies vaccine |
06/07/1915 |
08/11/1982 |
|
Streptococcus vaccine |
04/17/1952 |
10/27/1988 |
|
Tetanus toxoid |
12/10/1935 |
06/07/1979 |
|
Tetanus toxoid, adsorbed |
09/09/1970 |
06/07/1979 |
|
Tetanus & diphtheria toxoid adsorbed (for adult use) |
09/09/1970 |
06/07/1979 |
|
Typhoid |
02/04/1954 |
11/13/1978 |
|
Typhus |
03/11/1941 |
06/07/1979 |
|
Evans Medical Ltd.c |
|
|
|
Influenza |
08/12/1988 |
|
|
Glaxo Operations, U.K. Ltd.a |
|
|
|
BCG vaccine |
01/24/1963 |
07/17/1990 |
|
Lederle Laboratories,d |
|
|
|
American Cyanamid Company |
|
|
|
Cholera |
12/26/1941 |
|
|
Diphtheria & tetanus toxoids and acellular pertussis, adsorbed |
12/17/1991 |
|
|
Diphtheria & tetanus toxoids and pertussis vaccine adsorbed |
07/24/1970 |
|
|
DT, adsorbed |
07/29/1970 |
|
|
Haemophilus influenzae type b polysaccharide vaccine |
12/20/1985 |
|
|
Influenza |
12/07/1945 |
|
|
Measles virus, live |
05/03/1966 |
05/21/1980 |
|
Mumps vaccine |
06/22/1950 |
05/24/1978 |
|
Pertussis vaccine |
01/19/1914 |
05/29/1980 |
|
Pneumococcal vaccine, polyvalent |
08/15/1979 |
|
|
Polio virus, live, oral trivalent |
06/25/1963 |
|
|
Polio virus, oral, type 1 |
03/27/1962 |
|
|
Polio virus, oral, type 2 |
03/27/1962 |
|
|
Polio virus, oral, type 3 |
03/27/1962 |
|
|
Rocky mountain spotted fever |
04/13/1942 |
06/11/1979 |
|
Small pox |
03/01/1937 |
05/24/1978 |
|
Tetanus toxoid |
06/15/1935 |
|
|
Tetanus toxoid, adsorbed |
07/29/1970 |
|
|
Company and Vaccine or Product |
Date of License |
Date of Revocation |
|
Tetanus & Diphtheria toxoids adsorbed (for adult use) |
07/29/1970 |
|
|
Typhus |
05/24/1967 |
11/20/1980 |
|
Massachusetts Public Health Biologic Laboratories |
|
|
|
Diphtheria & tetanus toxoids & pertussis vaccine adsorbed |
07/27/1970 |
|
|
Diphtheria toxoid |
07/07/1932 |
05/19/1980 |
|
DT, adsorbed |
07/27/1970 |
|
|
Small pox |
03/20/1917 |
12/22/1976 |
|
Tetanus toxoid |
05/16/1949 |
10/11/1989 |
|
Tetanus toxoid, adsorbed |
07/29/1970 |
|
|
Tetanus & diphtheria toxoids adsorbed (for adult use) |
07/27/1970 |
|
|
Typhoid |
03/20/1917 |
10/26/1988 |
|
Merck and Company |
|
|
|
Cholera |
05/04/1952 |
01/31/1986 |
|
Diphtheria & tetanus toxoids and pertussis vaccine adsorbed |
08/31/1970 |
01/31/1986 |
|
Haemophilus influenzae type b conjugate (meningococcal protein conjugate) |
2/20/1989 |
|
|
Hepatitis B vaccine |
11/16/1981 |
|
|
Hepatitis B recombinant |
07/23/1986 |
|
|
Influenza |
11/30/1945 |
|
|
Measles, live and small pox |
11/17/1967 |
05/12/1987 |
|
Measles virus, live |
03/21/1963 |
|
|
Measles and mumps virus, live |
07/18/1973 |
|
|
Measles and rubella virus, live |
04/22/1971 |
|
|
Measles, mumps, rubella, live |
04/22/1971 |
|
|
Meningococcal polysaccharide A |
07/11/1975 |
|
|
Meningococcal polysaccharide C |
04/02/1974 |
|
|
Meningococcal polysaccharide A&C |
10/06/1975 |
|
|
Meningococcal polysaccharide A. C, Y, W135 combined |
12/14/1982 |
|
|
Mumps virus, live |
12/28/1967 |
|
|
Pneumococcal |
11/21/1977 |
|
|
Poliomyelitis, inactivated monkey kidney cell |
04/12/1955 |
07/29/1980 |
|
Rubella virus, live |
06/09/1969 |
|
|
Rubella and mumps, live |
08/30/1970 |
|
|
Small pox |
09/21/1965 |
07/29/1980 |
|
Tetanus toxoid |
12/11/1933 |
01/31/1986 |
|
Tetanus toxoid, adsorbed |
08/31/1970 |
01/31/1986 |
|
Company and Vaccine or Product |
Date of License |
Date of Revocation |
|
Tetanus & diphtheria toxoids adsorbed (for adult use) |
08/31/1970 |
01/31/1986 |
|
Typhoid |
04/25/1963 |
01/31/1986 |
|
Typhus |
12/24/1941 |
07/29/1980 |
|
Merrell-National Laboratories, Division of Richardson Merrella |
|
|
|
Cholera |
02/27/1942 |
03/25/1976 |
|
DTP |
10/15/1970 |
01/03/1978 |
|
Diphtheria & tetanus toxoids & pertussis vaccine adsorbed |
05/16/1949 |
01/03/1978 |
|
Diphtheria toxoid |
09/28/1929 |
01/03/1978 |
|
Influenza |
09/16/1947 |
01/03/1978 |
|
Meningococcal polysaccharide group A |
09/19/1975 |
01/03/1978 |
|
Meningococcal polysaccharide group C |
07/11/1975 |
01/03/1978 |
|
Meningococcal polysaccharide vaccine, groups A and C, combined |
09/13/1976 |
01/03/1978 |
|
Pertussis vaccine |
11/16/1926 |
01/03/1978 |
|
Small pox |
03/05/1937 |
01/03/1978 |
|
Tetanus toxoid |
05/25/1934 |
01/03/1978 |
|
Tetanus toxoid, adsorbed |
10/15/1970 |
01/03/1978 |
|
Tetanus and diphtheria toxoids adsorbed (for adult use) |
03/07/1955 |
01/03/1978 |
|
Yellow fever |
05/22/1953 |
01/03/1978 |
|
Michigan Department of Public Health |
|
|
|
Anthrax |
11/04/1970 |
|
|
Diphtheria & tetanus toxoids and pertussis vaccine adsorbed |
08/27/1970 |
|
|
DT, adsorbed |
08/27/1970 |
|
|
Pertussis vaccine |
11/22/1935 |
02/03/1977 |
|
Pertussis vaccine, adsorbed |
10/12/1967 |
|
|
Rabies vaccine, adsorbed |
03/18/1988 |
|
|
Smallpox |
03/03/1937 |
06/25/1985 |
|
Tetanus toxoid, adsorbed |
08/27/1970 |
|
|
Typhoid |
07/26/1926 |
06/25/1985 |
|
Miles Inc.e |
|
|
|
Cholera |
10/03/1968 |
10/30/1970 |
|
Diphtheria and tetanus toxoids |
06/01/1951 |
10/30/1970 |
|
DTP |
05/04/1949 |
10/30/1970 |
|
Diphtheria & tetanus toxoids and pertussis vaccine adsorbed |
05/04/1949 |
10/30/1970 |
|
Diphtheria toxoid |
02/01/1928 |
10/30/1970 |
|
DT, adsorbed |
05/04/1949 |
10/30/1970 |
|
DP, adsorbed |
05/04/1949 |
10/30/1970 |
|
Company and Vaccine or Product |
Date of License |
Date of Revocation |
|
Pertussis vaccine |
08/03/1914 |
10/30/1970 |
|
Pertussis vaccine, adsorbed |
05/03/1948 |
10/30/1970 |
|
Plague |
05/14/1942 |
|
|
Poliomyelitis, inactivated monkey kidney cell |
04/12/1955 |
12/28/1978 |
|
Small pox |
08/21/1903 |
06/11/1973 |
|
Tetanus toxoid |
09/25/1940 |
11/01/1979 |
|
Tetanus toxoid, adsorbed |
05/04/1949 |
10/30/1970 |
|
Tetanus & diphtheria toxoids adsorbed (for adult use) |
11/16/1956 |
10/30/1970 |
|
Typhoid |
03/06/1916 |
10/30/1970 |
|
Organon Teknika Corporatione |
|
|
|
BCG vaccine |
06/21/1989 |
|
|
Parke Davis, Division of Warner Lambert Companya |
|
|
|
Adenovirus |
09/23/1957 |
07/29/1980 |
|
Adenovirus and influenza, combined aluminium phosphate adsorbed |
09/22/1959 |
07/29/1980 |
|
Diphtheria and tetanus toxoids |
07/29/1952 |
10/14/1981 |
|
DTP |
07/29/1952 |
10/14/1981 |
|
Diphtheria & tetanus toxoids & pertussis vaccine adsorbed |
07/08/1952 |
10/14/1981 |
|
Diphtheria toxoid |
08/17/1927 |
10/14/1981 |
|
DT, adsorbed |
07/08/1952 |
10/14/1981 |
|
DTP adsorbed, poliomyelitis |
12/20/1963 |
10/14/1981 |
|
DTP, poliomyelitis adsorbed |
03/25/1959 |
10/14/1981 |
|
Influenza |
11/26/1945 |
|
|
Pertussis |
04/16/1952 |
10/14/1981 |
|
Pertussis vaccine, adsorbed |
02/20/1952 |
10/14/1981 |
|
Poliomyelitis, adsorbed |
10/04/1960 |
07/29/1980 |
|
Poliomyelitis, inactivated monkey kidney cell |
04/12/1955 |
07/29/1980 |
|
Rabies vaccine |
08/05/1942 |
03/21/1973 |
|
Tetanus toxoid |
05/04/1940 |
10/14/1981 |
|
Tetanus toxoid, adsorbed |
07/08/1952 |
10/14/1981 |
|
Typhoid |
03/24/1916 |
02/24/1959 |
|
Typhus |
03/25/1942 |
08/05/1947 |
|
Pasteur Merieux Vaccins et Serums, S.A.b |
|
|
|
Poliomyelitis, inactivated monkey kidney cell |
12/21/1990 |
|
|
Rabies vaccine |
06/09/1980 |
|
|
Company and Vaccine or Product |
Date of License |
Date of Revocation |
|
Pfizer Ltd.a |
|
|
|
Poliovirus, live, oral trivalent |
10/28/1966 |
06/17/1979 |
|
Poliovirus, oral type 1 |
08/17/1961 |
06/12/1979 |
|
Poliovirus, oral type 2 |
10/06/1961 |
06/12/1979 |
|
Poliovirus, oral type 3 |
03/27/1962 |
06/12/1979 |
|
Praxis Biologics, Incorporatedd |
|
|
|
Haemophilus b conjugate vaccine (diphtheria CRM197 protein conjugate) |
12/21/1988 |
|
|
Haemophilus b polysaccharide vaccine |
04/12/1985 |
|
|
Research Foundation for Microbial Diseases, Osaka University |
|
|
|
Acellular pertussis vaccine concentrate |
08/20/1992 |
|
|
Japanese encephalitis virus vaccine inactivated |
12/10/1992 |
|
|
SCLAVO s.p.a.f |
|
|
|
Cholera |
08/19/1976 |
|
|
Diphtheria and tetanus toxoids and pertussis vaccine adsorbed |
03/31/1978 |
|
|
Diphtheria toxoid |
01/04/1963 |
|
|
DT, adsorbed |
03/31/1978 |
|
|
Tetanus toxoid |
01/04/1963 |
|
|
Tetanus toxoid, adsorbed |
08/05/1970 |
|
|
Tetanus & diphtheria toxoids adsorbed (for adult use) |
02/16/1979 |
|
|
SmithKline Beechame |
|
|
|
Hepatitis B, recombinant |
08/28/1989 |
|
|
Rubella virus, live |
03/12/1970 |
10/05/1982 |
|
Swiss Serum Institute |
|
|
|
Tetanus toxoid, adsorbed |
12/11/1970 |
|
|
Typhoid vaccine, oral, Ty21a |
12/15/1989 |
|
|
Takeda Chemical Industries, Ltd., |
|
|
|
Acellular pertussis vaccine concentrate (for further manufacturing) |
12/17/1991 |
|
|
Texas Department of Health Resources |
|
|
|
Diphtheria & tetanus toxoids & pertussis vaccine adsorbed |
07/27/1970 |
02/06/1979 |
|
Diphtheria toxoid |
01/06/1963 |
02/06/1979 |
|
DT, adsorbed |
07/27/1970 |
02/06/1979 |
|
Pertussis |
12/27/1954 |
02/06/1979 |
|
Company and Vaccine or Product |
Date of License |
Date of Revocation |
|
Tetanus toxoid |
09/22/1959 |
02/06/1979 |
|
Tetanus & diphtheria toxoids adsorbed (for adult use) |
07/27/1970 |
02/06/1979 |
|
Typhoid |
07/11/1950 |
02/06/1979 |
|
University of Illinoisa |
|
|
|
BCG vaccine |
07/07/1950 |
05/29/1987 |
|
Wellcomed |
|
|
|
Rubella virus, live |
03/01/1977 |
|
|
Wyeth Laboratories |
|
|
|
Adenovirus, live, oral, type 4 |
07/01/1980 |
|
|
Adenovirus, live, oral, type 7 |
07/01/1980 |
|
|
Cholera |
07/16/1952 |
|
|
Diphtheria & tetanus toxoids and pertussis vaccine adsorbed |
09/11/1970 |
|
|
Diphtheria toxoid |
05/19/1944 |
05/19/1987 |
|
DT, adsorbed |
09/11/1970 |
|
|
Influenza |
12/13/1961 |
|
|
Pertussis vaccine |
07/16/1952 |
05/19/1987 |
|
Rabies vaccine |
08/11/1982 |
08/07/1986 |
|
Smallpox |
05/19/1944 |
|
|
Tetanus toxoid |
05/19/1944 |
|
|
Tetanus toxoid, adsorbed |
09/11/1970 |
|
|
Tetanus & diphtheria toxoids adsorbed (for adult use) |
09/11/1970 |
|
|
Typhoid |
07/16/1952 |
|
|
a Company no longer produces any vaccines. b Connaught Laboratories, Inc., (U.S.) and Connaught Laboratories, Ltd (Canada), are subsidiaries of Pasteur-Mérieux Sérums et Vaccins (France). c Evans-Medical is a division of Medeva International, plc (United Kingdom); Medeva International plc acquired the vaccine business from Wellcome in 1991. d Lederle Laboratories acquired Praxis Biologics in 1989. Lederle-Praxis Biologicals is now a business unit of American Cyanamid. e Company produces one vaccine only for U.S. market. f Sclavo spa is now owned by Ciba-Geigy (Switzerland) and Chiron (U.S.). SOURCE: Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Bethesda, Maryland. |
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