Assessment of the Department of Veterans Affairs Airborne Hazards and Open Burn Pit Registry (2017)

Chapter: Appendix E: Multivariate Model Results

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Suggested Citation: "Appendix E: Multivariate Model Results." National Academies of Sciences, Engineering, and Medicine. 2017. Assessment of the Department of Veterans Affairs Airborne Hazards and Open Burn Pit Registry. Washington, DC: The National Academies Press. doi: 10.17226/23677.
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Appendix E

Multivariate Model Results

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Suggested Citation: "Appendix E: Multivariate Model Results." National Academies of Sciences, Engineering, and Medicine. 2017. Assessment of the Department of Veterans Affairs Airborne Hazards and Open Burn Pit Registry. Washington, DC: The National Academies Press. doi: 10.17226/23677.
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TABLE E-1 Multivariate Model Results of Burn Pit Exposure Variables and Respiratory and Cardiovascular Health Outcomes

Asthma (N = 36,446) Emphysema, Chronic Bronchitis, or COPD (N = 35,383) Any Respiratory Symptoms (N = 39,271) Functional Limitation Due to Lung Problem (N = 37,903)
OR LCL UCL P OR LCL UCL P OR LCL UCL P OR LCL UCL P
Near Burn Pit
Q 2 1.1 1.0 1.2 0.24 1.0 0.9 1.2 0.53 1.2 1.1 1.3 * 1.1 1.0 1.2 *
Q 3 1.2 1.1 1.4 * 1.3 1.1 1.4 * 1.3 1.2 1.5 * 1.2 1.1 1.4 *
Q 4 1.3 1.2 1.6 * 1.5 1.3 1.8 * 1.8 1.6 2.0 * 1.4 1.3 1.6 *
Burn Pit Duty
Q 2 1.3 1.1 1.4 * 1.5 1.3 1.6 * 1.4 1.3 1.5 * 1.2 1.1 1.3 *
Q 3 1.2 1.1 1.3 * 1.3 1.2 1.4 * 1.4 1.3 1.5 * 1.3 1.2 1.4 *
Q 4 1.4 1.2 1.5 * 1.6 1.4 1.7 * 1.8 1.7 2.0 * 1.4 1.3 1.5 *
Smoke Hours
Q 2 1.1 1.0 1.2 0.07 1.3 1.2 1.5 * 1.3 1.2 1.4 * 1.2 1.1 1.3 *
Q 3 1.2 1.1 1.3 * 1.6 1.5 1.8 * 1.7 1.6 1.8 * 1.5 1.4 1.6 *
Q 4 1.5 1.3 1.6 * 2.0 1.8 2.2 * 2.3 2.1 2.4 * 1.9 1.8 2.1 *
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Suggested Citation: "Appendix E: Multivariate Model Results." National Academies of Sciences, Engineering, and Medicine. 2017. Assessment of the Department of Veterans Affairs Airborne Hazards and Open Burn Pit Registry. Washington, DC: The National Academies Press. doi: 10.17226/23677.
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Hypertension (N = 36,770) CAD, MI, or Angina Pectoris (N = 35,740)
OR LCL UCL P OR LCL UCL P
Near Burn Pit
Q 2 1.0 0.9 1.1 0.74 1.1 0.9 1.4 0.40
Q 3 1.2 1.1 1.3 * 1.3 1.0 1.7 0.04
Q 4 1.2 1.1 1.4 * 1.6 1.2 2.2 *
Burn Pit Duty
Q 2 1.2 1.1 1.3 * 1.3 1.0 1.6 0.02
Q 3 1.1 1.0 1.2 * 1.0 0.8 1.2 1.00
Q 4 1.3 1.2 1.4 * 1.4 1.1 1.7 *
Smoke Hours
Q 2 1.1 1.1 1.2 * 1.3 1.1 1.6 *
Q 3 1.3 1.2 1.4 * 1.4 1.1 1.7 *
Q 4 1.4 1.3 1.5 * 1.8 1.5 2.2 *

NOTES: The first quartile is the reference group. CAD = coronary artery disease; COPD = chronic obstructive pulmonary disease; LCL = lower confidence level; MI = myocardial infarction; OR = odds ratio; P = p-value; Q2 = second quartile; Q3 = third quartile; Q4 = fourth quartile; UCL = upper confidence level.

* Denotes p-value <0.01.

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Suggested Citation: "Appendix E: Multivariate Model Results." National Academies of Sciences, Engineering, and Medicine. 2017. Assessment of the Department of Veterans Affairs Airborne Hazards and Open Burn Pit Registry. Washington, DC: The National Academies Press. doi: 10.17226/23677.
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TABLE E-2 Model Estimates of Plausible and Implausible Levels of Burn Pit Exposure on Respiratory and Cardiovascular Health Outcomes

Asthma (N = 36,446) Emphysema, Chronic Bronchitis, or COPD (N = 35,383) Any Respiratory Symptoms (N = 39,271) Functional Limitation Due to Lung Problems (N = 37,903)
OR LCL UCL P OR LCL UCL P OR LCL UCL P OR LCL UCL P
Plausible Near Burn Pit
Q 2 1.0 0.9 1.1 0.68 0.9 0.8 1.0 0.20 1.1 1.0 1.2 * 1.0 1.0 1.1 0.26
Q 3 1.0 0.9 1.1 0.64 1.0 0.9 1.1 0.93 1.2 1.1 1.2 * 1.1 1.0 1.2 0.06
Q 4 1.0 0.9 1.1 0.65 0.9 0.8 1.0 0.01 1.3 1.2 1.4 * 1.1 1.0 1.2 0.28
Implausible Near Burn Pit
Q 2 1.0 0.9 1.1 0.51 1.0 1.0 1.1 0.35 1.0 1.0 1.1 0.51 1.1 1.0 1.2 *
Q 3 1.0 1.0 1.1 0.31 1.2 1.1 1.3 * 1.0 0.9 1.0 0.51 1.1 1.0 1.1 0.04
Q 4 1.0 0.9 1.1 0.88 1.1 1.0 1.2 0.18 0.8 0.7 0.9 * 0.9 0.9 1.0 0.17
Plausible Burn Pit Duty
Q 2 1.4 1.2 1.5 * 1.5 1.3 1.6 * 1.4 1.3 1.5 * 1.2 1.1 1.4 *
Q 3 1.2 1.1 1.3 * 1.2 1.1 1.3 * 1.4 1.3 1.5 * 1.2 1.2 1.3 *
Q 4 1.3 1.1 1.4 * 1.4 1.3 1.5 * 1.7 1.6 1.8 * 1.4 1.3 1.5 *
Implausible Burn Pit Duty
Q 2 0.9 0.8 1.0 0.07 1.0 0.9 1.1 0.92 0.9 0.8 0.9 * 0.9 0.9 1.0 0.04
Q 3 0.8 0.8 0.9 * 0.9 0.8 1.0 * 0.7 0.7 0.8 * 0.8 0.7 0.8 *
Q 4 0.8 0.7 0.9 * 0.7 0.6 0.8 * 0.5 0.5 0.6 * 0.7 0.6 0.8 *
Plausible Smoke Hours
Q 2 1.1 1.0 1.2 0.19 1.3 1.2 1.4 * 1.3 1.2 1.4 * 1.2 1.1 1.3 *
Q 3 1.2 1.1 1.3 * 1.6 1.4 1.7 * 1.6 1.5 1.7 * 1.5 1.4 1.6 *
Q 4 1.3 1.2 1.4 * 1.7 1.5 1.9 * 2.1 1.9 2.2 * 1.8 1.6 1.9 *
Page 225 Cite Bookmark
Suggested Citation: "Appendix E: Multivariate Model Results." National Academies of Sciences, Engineering, and Medicine. 2017. Assessment of the Department of Veterans Affairs Airborne Hazards and Open Burn Pit Registry. Washington, DC: The National Academies Press. doi: 10.17226/23677.
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Hypertension (N = 36,770) CAD, MI, or Angina Pectoris (N = 35,740)
OR LCL UCL P OR LCL UCL P
Plausible Near Burn Pit
Q 2 0.8 0.8 0.9 * 0.7 0.6 0.9 *
Q 3 0.9 0.9 1.0 0.13 0.7 0.6 0.9 *
Q 4 0.8 0.8 0.9 * 0.6 0.5 0.8 *
Implausible Near Burn Pit
Q 2 1.0 1.0 1.1 0.37 1.0 0.8 1.2 0.98
Q 3 1.1 1.1 1.2 * 1.3 1.0 1.5 0.02
Q 4 1.2 1.1 1.3 * 1.3 1.1 1.6 0.01
Plausible Burn Pit Duty
Q 2 1.2 1.1 1.3 * 1.3 1.1 1.6 0.01
Q 3 1.0 1.0 1.1 0.31 0.9 0.8 1.1 0.35
Q 4 1.1 1.1 1.2 * 1.1 0.9 1.4 0.21
Implausible Burn Pit Duty
Q 2 1.0 1.0 1.1 0.47 1.0 0.8 1.2 0.94
Q 3 1.0 0.9 1.0 0.28 1.0 0.8 1.2 0.76
Q 4 1.0 0.9 1.0 0.28 0.9 0.7 1.1 0.19
Plausible Smoke Hours
Q 2 1.1 1.0 1.2 0.01 1.3 1.1 1.5 0.01
Q 3 1.2 1.1 1.3 * 1.3 1.1 1.6 *
Q 4 1.3 1.2 1.4 * 1.5 1.2 1.8 *

NOTES: The first quartile is the reference group. CAD = coronary artery disease; COPD = chronic obstructive pulmonary disease; LCL = lower confidence level; MI = myocardial infarction; OR = odds ratio; P = p-value; Q2 = second quartile; Q3 = third quartile; Q4 = fourth quartile; UCL = upper confidence level.

* Denotes p-value <0.01.

Page 226 Cite Bookmark
Suggested Citation: "Appendix E: Multivariate Model Results." National Academies of Sciences, Engineering, and Medicine. 2017. Assessment of the Department of Veterans Affairs Airborne Hazards and Open Burn Pit Registry. Washington, DC: The National Academies Press. doi: 10.17226/23677.
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TABLE E-3 Multivariate Model Results of Respiratory and Cardiovascular Health Outcomes by Exposure Category and Level

Asthma Emphysema, Chronic Bronchitis, or COPD Any Respiratory Symptoms Functional Limitation Due to Lung Problem
OR LCL UCI P OR LCL UCL P OR LCL UCL P OR LCL UCL P
Burn Pits
1 1.1 0.9 1.3 0.31 1.2 1.0 1.5 0.03 1.1 1.0 1.2 0.05 1.1 1.0 1.3 0.07
2 1.3 1.1 1.5 * 1.5 1.2 1.7 * 1.3 1.2 1.4 * 1.4 1.2 1.6 *
3 1.5 1.3 1.7 * 1.6 1.3 1.9 * 1.5 1.4 1.7 * 1.6 1.4 1.8 *
4 1.4 1.2 1.6 * 1.7 1.4 2.0 * 1.5 1.4 1.7 * 1.4 1.3 1.6 *
5 1.5 1.3 1.8 * 2.1 1.8 2.4 * 2.0 1.8 2.2 * 1.8 1.6 2.0 *
6 1.8 1.6 2.1 * 2.5 2.1 2.9 * 2.8 2.5 3.0 * 2.3 2.0 2.5 *
Diesel/Exhaust/Fuel
1 1.2 1.1 1.4 * 1.2 1.1 1.4 * 1.2 1.1 1.3 * 1.1 1.0 1.3 0.01
2 1.3 1.2 1.5 * 1.5 1.3 1.7 * 1.4 1.3 1.5 * 1.2 1.1 1.3 *
3 1.4 1.2 1.6 * 1.5 1.3 1.7 * 1.7 1.5 1.8 * 1.4 1.3 1.6 *
4 1.5 1.3 1.7 * 1.6 1.4 1.8 * 1.8 1.6 2.0 * 1.5 1.4 1.7 *
5 1.6 1.4 1.9 * 2.0 1.7 2.3 * 2.2 2.0 2.5 * 1.7 1.5 1.9 *
6 1.6 1.4 1.9 * 2.1 1.8 2.5 * 2.4 2.1 2.8 * 1.8 1.6 2.0 *
Page 227 Cite Bookmark
Suggested Citation: "Appendix E: Multivariate Model Results." National Academies of Sciences, Engineering, and Medicine. 2017. Assessment of the Department of Veterans Affairs Airborne Hazards and Open Burn Pit Registry. Washington, DC: The National Academies Press. doi: 10.17226/23677.
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Construction
3 1.1 1.0 1.2 0.05 1.3 1.2 1.4 * 1.4 1.3 1.5 * 1.2 1.2 1.3 *
6 1.3 1.2 1.4 * 1.5 1.4 1.6 * 1.7 1.6 1.8 * 1.4 1.3 1.5 *
Dust
1 1.1 0.9 1.3 0.64 0.9 0.8 1.1 0.51 1.1 1.0 1.3 0.09 1.1 0.9 1.2 0.48
2 1.1 0.9 1.4 0.19 1.1 0.9 1.4 0.19 1.3 1.2 1.5 * 1.2 1.0 1.4 0.01
3 1.3 1.1 1.6 * 1.4 1.2 1.7 * 1.7 1.5 1.9 * 1.4 1.2 1.7 *
4 1.4 1.2 1.7 * 1.7 1.4 2.0 * 2.0 1.8 2.3 * 1.6 1.4 1.9 *
5 1.6 1.3 2.0 * 1.9 1.5 2.3 * 2.6 2.3 3.0 * 1.9 1.6 2.2 *
6 1.8 1.4 2.2 * 2.5 2.0 3.1 * 3.2 2.7 3.8 * 2.3 1.9 2.7 *
Combat
1 1.1 0.9 1.4 0.27 1.2 0.9 1.4 0.20 1.0 0.8 1.1 0.49 1.1 0.9 1.3 0.22
2 1.4 1.2 1.6 * 1.7 1.5 2.0 * 1.5 1.3 1.6 * 1.4 1.2 1.5 *
3 1.4 1.2 1.6 * 1.6 1.4 1.9 * 1.5 1.4 1.7 * 1.4 1.3 1.6 *
4 1.6 1.4 1.8 * 2.0 1.8 2.4 * 1.8 1.7 2.0 * 1.5 1.4 1.7 *
5 1.7 1.5 2.0 * 2.4 2.0 2.7 * 2.1 1.9 2.3 * 1.8 1.7 2.0 *
1.9 1.7 2.2 * 2.9 2.5 3.3 * 2.8 2.5 3.1 * 2.1 1.9 2.4 *
Page 228 Cite Bookmark
Suggested Citation: "Appendix E: Multivariate Model Results." National Academies of Sciences, Engineering, and Medicine. 2017. Assessment of the Department of Veterans Affairs Airborne Hazards and Open Burn Pit Registry. Washington, DC: The National Academies Press. doi: 10.17226/23677.
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Hypertension CAD, MI, or Angina Pectoris
OR LCL UCL P OR LCL UCL P
Burn Pits
1 1.1 1.0 1.2 0.25 1.0 0.7 1.5 0.89
2 1.2 1.1 1.4 * 1.1 0.8 1.6 0.48
3 1.2 1.1 1.4 * 1.0 0.7 1.4 1.00
4 1.3 1.1 1.4 * 1.4 1.0 1.9 0.07
5 1.4 1.2 1.5 * 1.4 1.0 1.9 0.05
6 1.6 1.4 1.8 * 1.8 1.3 2.4 *
Diesel/Exhaust/Fuel
1 1.1 1.0 1.2 0.01 1.5 1.1 2.0 *
2 1.2 1.1 1.3 * 1.7 1.3 2.3 *
3 1.3 1.2 1.4 * 1.9 1.4 2.5 *
4 1.2 1.1 1.3 * 1.4 1.0 1.9 0.03
5 1.4 1.3 1.6 * 2.1 1.5 2.9 *
6 1.6 1.4 1.8 * 2.5 1.7 3.5 *
Page 229 Cite Bookmark
Suggested Citation: "Appendix E: Multivariate Model Results." National Academies of Sciences, Engineering, and Medicine. 2017. Assessment of the Department of Veterans Affairs Airborne Hazards and Open Burn Pit Registry. Washington, DC: The National Academies Press. doi: 10.17226/23677.
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Construction
3 1.2 1.0 1.4 0.04 1.2 1.0 1.4 0.04
6 1.6 1.3 1.9 * 1.6 1.3 1.9 *
Dust
1 0.9 0.8 1.1 0.31 1.0 0.6 1.5 0.92
2 1.1 1.0 1.2 0.21 1.2 0.8 1.8 0.42
3 1.2 1.1 1.4 * 1.4 0.9 2.2 0.11
4 1.3 1.2 1.5 * 1.5 1.0 2.3 0.05
5 1.4 1.2 1.7 * 2.0 1.3 3.1 *
6 1.7 1.4 2.0 * 2.3 1.5 3.7 *
Combat
1 1.1 1.0 1.3 0.17 1.4 0.9 2.2 0.10
2 1.3 1.2 1.4 * 1.3 0.9 1.7 0.11
3 1.3 1.1 1.4 * 1.6 1.1 2.3 0.01
4 1.5 1.3 1.6 * 1.8 1.3 2.4 *
5 1.6 1.5 1.8 * 2.0 1.4 2.6 *
6 1.7 1.6 1.9 * 2.1 1.5 2.8 *

NOTES: The unexposed group is the reference group. CAD = coronary artery disease; COPD = chronic obstructive pulmonary disease; LCL = lower confidence limit; MI = myocardial infarction; OR = odds ratio; P = p-value; UCL = upper confidence limit.

* Denotes p-value <0.01.

Page 230 Cite Bookmark
Suggested Citation: "Appendix E: Multivariate Model Results." National Academies of Sciences, Engineering, and Medicine. 2017. Assessment of the Department of Veterans Affairs Airborne Hazards and Open Burn Pit Registry. Washington, DC: The National Academies Press. doi: 10.17226/23677.
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TABLE E-4 Multivariate Model Results of Composite Exposure Potential Measure and Respiratory and Cardiovascular Health Outcomes

Composite Exposure Asthma (N = 36,446) Emphysema, Chronic Bronchitis or COPD (N = 35,383) Any Respiratory Symptoms (N = 39,271) Functional Limitation Due to Lung Problem (N = 37,903)
OR LCL UCL P OR LCL UCL P OR LCL UCL P OR LCL UCL P
Q 2 1.2 1.1 1.3 * 1.4 1.2 1.5 * 1.4 1.3 1.5 * 1.3 1.2 1.4 *
Q 3 1.5 1.4 1.6 * 1.7 1.6 1.9 * 1.9 1.7 2.0 * 1.5 1.4 1.7 *
Q 4 1.7 1.5 1.8 * 2.3 2.1 2.6 * 2.7 2.5 2.9 * 2.0 1.8 2.1 *

Composite Exposure Hypertension (N = 36,770) CAD, MI, or Angina Pectoris (N = 35,740)
OR LCL UCL P OR LCL UCL P
Q 2 1.2 1.1 1.3 * 1.2 1.0 1.6 0.07
Q 3 1.4 1.3 1.5 * 1.5 1.3 1.9 *
Q 4 1.7 1.6 1.8 * 2.1 1.7 2.6 *

NOTES: The first quartile is the reference group. CAD = coronary artery disease; COPD = chronic obstructive pulmonary disease; LCL = lower confidence level; MI = myocardial infarction; OR = odds ratio; P = p-value; Q2 = second quartile; Q3 = third quartile; Q4 = fourth quartile; UCL = upper confidence level.

* Denotes p-value <0.01.

Page 221 Cite Bookmark
Suggested Citation: "Appendix E: Multivariate Model Results." National Academies of Sciences, Engineering, and Medicine. 2017. Assessment of the Department of Veterans Affairs Airborne Hazards and Open Burn Pit Registry. Washington, DC: The National Academies Press. doi: 10.17226/23677.
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Suggested Citation: "Appendix E: Multivariate Model Results." National Academies of Sciences, Engineering, and Medicine. 2017. Assessment of the Department of Veterans Affairs Airborne Hazards and Open Burn Pit Registry. Washington, DC: The National Academies Press. doi: 10.17226/23677.
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Suggested Citation: "Appendix E: Multivariate Model Results." National Academies of Sciences, Engineering, and Medicine. 2017. Assessment of the Department of Veterans Affairs Airborne Hazards and Open Burn Pit Registry. Washington, DC: The National Academies Press. doi: 10.17226/23677.
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Suggested Citation: "Appendix E: Multivariate Model Results." National Academies of Sciences, Engineering, and Medicine. 2017. Assessment of the Department of Veterans Affairs Airborne Hazards and Open Burn Pit Registry. Washington, DC: The National Academies Press. doi: 10.17226/23677.
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Suggested Citation: "Appendix E: Multivariate Model Results." National Academies of Sciences, Engineering, and Medicine. 2017. Assessment of the Department of Veterans Affairs Airborne Hazards and Open Burn Pit Registry. Washington, DC: The National Academies Press. doi: 10.17226/23677.
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Suggested Citation: "Appendix E: Multivariate Model Results." National Academies of Sciences, Engineering, and Medicine. 2017. Assessment of the Department of Veterans Affairs Airborne Hazards and Open Burn Pit Registry. Washington, DC: The National Academies Press. doi: 10.17226/23677.
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Suggested Citation: "Appendix E: Multivariate Model Results." National Academies of Sciences, Engineering, and Medicine. 2017. Assessment of the Department of Veterans Affairs Airborne Hazards and Open Burn Pit Registry. Washington, DC: The National Academies Press. doi: 10.17226/23677.
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Suggested Citation: "Appendix E: Multivariate Model Results." National Academies of Sciences, Engineering, and Medicine. 2017. Assessment of the Department of Veterans Affairs Airborne Hazards and Open Burn Pit Registry. Washington, DC: The National Academies Press. doi: 10.17226/23677.
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Suggested Citation: "Appendix E: Multivariate Model Results." National Academies of Sciences, Engineering, and Medicine. 2017. Assessment of the Department of Veterans Affairs Airborne Hazards and Open Burn Pit Registry. Washington, DC: The National Academies Press. doi: 10.17226/23677.
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Suggested Citation: "Appendix E: Multivariate Model Results." National Academies of Sciences, Engineering, and Medicine. 2017. Assessment of the Department of Veterans Affairs Airborne Hazards and Open Burn Pit Registry. Washington, DC: The National Academies Press. doi: 10.17226/23677.
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Next Chapter: Appendix F: Biographical Sketches of Committee Members and Staff
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