Part IV of this report offers this committee’s perspective on knowledge gaps it revealed through its review of the evidence. This part of the report consists of one chapter.

Chapter 12 synthesizes the committee’s assessment of the evidence to identify where research gaps exist related to the understanding of potassium and sodium intake levels that are adequate, are toxic, and reduce chronic disease risk. The committee also describes its experience of undertaking a Dietary Reference Intake (DRI) study that incorporated recommendations from the 2017 National Academies report Guiding Principles for Developing Dietary Reference Intakes Based on Chronic Disease and used an externally prepared systematic evidence review. Based on its experience, the committee highlights opportunities to enhance the DRI process.

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Front Matter i-xvi
Summary 1-16
Part I 17-18
1 Introduction 19-36
2 Applying the "Guiding Principles Report" 37-60
3 Methodological Considerations 61-98
Part II 99-100
4 Potassium: Dietary Reference Intakes for Adequacy 101-124
5 Potassium: Dietary Reference Intakes for Toxicity 125-140
6 Potassium: Dietary Reference Intakes Based on Chronic Disease 141-182
7 Potassium Dietary Reference Intakes: Risk Characterization and Special Considerations for Public Health 183-204
Part III 205-206
8 Sodium: Dietary Reference Intakes for Adequacy 207-244
9 Sodium: Dietary Reference Intakes for Toxicity 245-262
10 Sodium: Dietary Reference Intakes Based on Chronic Disease 263-368
11 Sodium Dietary Reference Intakes: Risk Characterization and Special Considerations for Public Health 369-398
Part IV 399-400
12 Knowledge Gaps and Future Directions 401-420
Appendix A: Acronyms and Abbreviations 421-424
Appendix B: Open Session Agendas 425-430
Appendix C: Committee's Assessment of the "Agency for Healthcare Research and Quality Systematic Review" 431-446
Appendix D: Indicators Not Relevant for Establishing Dietary Reference Intake Values 447-484
Appendix E: Supplemental Literature Searches 485-522
Appendix F: Estimates of Potassium and Sodium Intakes from Breast Milk and Complementary Foods 523-540
Appendix G: Sources of Evidence for Potassium and Sodium Intake Distributions 541-548
Appendix H: Supplemental Risk Characterization Figures 549-556
Appendix I: Committee Member Biographical Sketches 557-564
Appendix J: Dietary Reference Intakes Summary Tables 565-578

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Dietary Reference Intakes for Sodium and Potassium (2019)

Chapter: Part IV

Part IV

My Academies

Dietary Reference Intakes for Sodium and Potassium (2019)

Chapter: Part IV

Part IV