| ACD | Advisory Committee to the Director |
| ACRF | Ambulatory Clinical Research Facility |
| ARRA | American Recovery and Reinvestment Act |
| ARS | USDA Agricultural Research Service |
| ASPR | Assistant Secretary for Preparedness and Response |
| B&F | Buildings and Facilities |
| BARDA | Biomedical Advanced Research and Development Authority |
| BC | Bethesda Campus |
| BMAR | Backlog of Maintenance and Repair |
| BSC | Balanced Scorecard |
| CC | Clinical Center |
| CCWG | Clinical Center Working Group |
| CDC | Centers for Disease Control and Prevention |
| CDR | Center for Disease Research |
| CI | Condition Index |
| CISIP | Condition Index, Sustainment, and Improvement Funding Needs Plan |
| CIT | Center for Information Technology |
| CIT | communications and information technology |
| CORBEL | Coordinated Research Infrastructures Building Enduring Life-Science Services |
| CRC | Clinical Research Center |
| CREx | Collaborative Research Exchange |
| CRV | Current Replacement Value |
| CSR | Center for Scientific Review |
| CUP | Central Utility Plant |
| Cx | commissioning |
| DFOM | Division of Facilities, Operations, and Maintenance |
| DFP | Division of Facilities Planning |
| DHS | Department of Homeland Security |
| DoD | Department of Defense |
| DOE | Department of Energy |
| DRM | Design Requirements Manual |
| DTR | Division of Technical Resources |
| DVR | Division of Veterinary Resources |
| EIS | Executive Information System |
| EO | executive officer |
| F&I | facilities and infrastructure |
| FAES | Foundation for Advanced Education in the Sciences |
| FDA | Food and Drug Administration |
| FEMP | Federal Energy Management Program |
| FIC | Fogarty International Center |
| FNIH | Foundation for the National Institutes of Health |
| FPAA | Facility Project Approval Agreement |
| FRV | Functional Replacement Value |
| FTE | full-time equivalent |
| FWG | Facilities Working Group |
| FY | fiscal year |
| GAO | Government Accountability Office |
| GSA | General Services Administration |
| HHS | Department of Health and Human Services |
| HPC | high-performance computing |
| ICs | institutes and centers |
| IDA | Institute for Defense Analyses |
| IPD | Intramural Professional Designation |
| IRP | Intramural Research Program |
| IRTA/CRTA | Intramural Research Training Award, denominated CRTA at NCI |
| LCCA | Life Cycle Cost Analysis |
| LSP | Lease Space Plan |
| MDI | Mission Dependency Index |
| MRI | magnetic resonance imaging |
| NASA | National Aeronautics and Space Administration |
| NASEM | National Academies of Sciences, Engineering, and Medicine |
| NASF | net assignable square feet |
| NCATS | National Center for Advancing Translational Sciences |
| NCCIH | National Center for Complementary and Integrative Health |
| NCI | National Cancer Institute |
| NCPC | National Capital Planning Commission |
| NEF | nonrecurring expense fund |
| NEI | National Eye Institute |
| NHGRI | National Human Genome Research Institute |
| NHLBI | National Heart, Lung, and Blood Institute |
| NIA | National Institute on Aging |
| NIAAA | National Institute on Alcohol Abuse and Alcoholism |
| NIAID | National Institute of Allergy and Infectious Diseases |
| NIAMS | National Institute of Arthritis and Musculoskeletal and Skin Diseases |
| NIBIB | National Institute of Biomedical Imaging and Bioengineering |
| NICHD | Eunice Kennedy Shriver National Institute of Child Health and Human Development |
| NIDA | National Institute on Drug Abuse |
| NIDCD | National Institute on Deafness and Other Communication Disorders |
| NIDCR | National Institute of Dental and Craniofacial Research |
| NIDDK | National Institute of Diabetes and Digestive and Kidney Diseases |
| NIEHS | National Institute of Environmental Health Sciences |
| NIGMS | National Institute of General Medical Sciences |
| NIH | National Institutes of Health |
| NIH-BC | National Institutes of Health-Bethesda Campus |
| NIMH | National Institute of Mental Health |
| NIMHD | National Institute on Minority Health and Health Disparities |
| NINDS | National Institute of Neurological Disorders and Stroke |
| NINR | National Institute of Nursing Research |
| NIST | National Institute of Standards and Technology |
| NLM | National Library of Medicine |
| NPS | National Park Service |
| NRC | National Research Council |
| NRL | Naval Research Laboratory |
| OD | Office of the Director |
| OIR | Office of Intramural Research |
| OITE | Office of Intramural Training and Education |
| OMB | Office of Management and Budget |
| OPDIV | Operating Division |
| ORF | Office of Research Facilities |
| ORS | Office of Research Services |
| PCT | Project Contract Team |
| PHEMCE | Public Health Emergency Medical Countermeasures Enterprise |
| PHI | personal health information |
| PI | principal investigator |
| POR | program of requirements |
| PNRC | Porter Neuroscience Research Center |
| R&D | research and development |
| RFAC | Research Facilities Advisory Committee |
| RI | research infrastructure |
| RML | Rocky Mountain Laboratory |
| SD | scientific director |
| SF | Square Feet |
| SFP | Space Facilities Plan |
| SRB | Space Recommendation Board |
| UARC | university-affiliated research center |
| USDA | U.S. Department of Agriculture |
| VA | Veterans Affairs |
| WDBG | Whole Building Design Guide |