Enhancing Scientific Reproducibility in Biomedical Research Through Transparent Reporting: Proceedings of a Workshop
2020

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Sharing knowledge is what drives scientific progress - each new advance or innovation in biomedical research builds on previous observations. However, for experimental findings to be broadly accepted as credible by the scientific community, they must be verified by other researchers. An essential step is for researchers to report their findings in a manner that is understandable to others in the scientific community and provide sufficient information for others to validate the original results and build on them. In recent years, concern has been growing over a number of studies that have failed to replicate previous results and evidence from larger meta-analyses, which have pointed to the lack of reproducibility in biomedical research.

On September 25 and 26, 2019, the National Academies of Science, Engineering, and Medicine hosted a public workshop in Washington, DC, to discuss the current state of transparency in the reporting of preclinical biomedical research and to explore opportunities for harmonizing reporting guidelines across journals and funding agencies. Convened jointly by the Forum on Drug Discovery, Development, and Translation; the Forum on Neuroscience and Nervous System Disorders; the National Cancer Policy Forum; and the Roundtable on Genomics and Precision Health, the workshop primarily focused on transparent reporting in preclinical research, but also considered lessons learned and best practices from clinical research reporting. This publication summarizes the presentation and discussion of the workshop.

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142 pages · 6 x 9 · paperback
ISBN Paperback: 0-309-66349-0
ISBN Ebook: 0-309-66350-4
DOI: https://doi.org/10.17226/25627

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National Academies of Sciences, Engineering, and Medicine. 2020. Enhancing Scientific Reproducibility in Biomedical Research Through Transparent Reporting: Proceedings of a Workshop. Washington, DC: The National Academies Press.

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Front Matter i-xxii
1 Introduction 1-4
2 Transparency and Trust 5-16
3 Approaches to Cultivate Transparent Reporting in Biomedical Research 17-34
4 Lessons Learned and Best Practices 35-52
5 Checklists and Guidelines 53-72
6 Toward Minimal Reporting Standards for Preclinical Biomedical Research 73-90
7 Stakeholder Opportunities for Promoting Transparent Reporting 91-100
Appendix A: References 101-104
Appendix B: Background Discussion Document: Selected Guidelines for Transparent Reporting 105-110
Appendix C: Workshop Agenda 111-120

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Enhancing Scientific Reproducibility in Biomedical Research Through Transparent Reporting: Proceedings of a Workshop (2020)

Chapter: 6 Toward Minimal Reporting Standards for Preclinical Biomedical Research

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Enhancing Scientific Reproducibility in Biomedical Research Through Transparent Reporting: Proceedings of a Workshop (2020)

Chapter: 6 Toward Minimal Reporting Standards for Preclinical Biomedical Research