Examining the State of the Science of Mammalian Embryo Model Systems: Proceedings of a Workshop (2020)
Chapter: Appendix A: Workshop Agenda
Appendix A
Workshop Agenda
Keck Center of the National Academies
Room 100
500 Fifth Street, NW
Washington, DC 20001
| 8:30 a.m. | Opening Remarks and Charge to Workshop Speakers and Participants |
MARTIN PERA | |
Professor | |
The Jackson Laboratory | |
| 8:45 a.m. | Opening Keynote Lecture |
| Unique Aspects of Human Embryology and Opportunities and Challenges with Stem Cell–Based Embryo Models | |
JANET ROSSANT | |
Senior Scientist, Developmental and Stem Cell Biology | |
The Hospital for Sick Children | |
| 9:05 a.m. | Clarifying Questions from Workshop Participants |
SESSION I: MAMMALIAN EMBRYO RESEARCH AND PLURIPOTENT STEM CELLS
SESSION OBJECTIVE:
- Explore the characteristics of mammalian embryo model systems and the potential benefits and limitations to using these models for studying human embryonic development.
Session Moderator: Renee Reijo Pera, California Polytechnic State University
| 9:20 a.m. | KATHY NIAKAN |
Group Leader | |
Francis Crick Institute | |
| 9:35 a.m. | MAGDALENA ZERNICKA-GOETZ |
Professor of Mammalian Development and Stem Cell Biology | |
University of Cambridge | |
Bren Professor of Biology and Biological Engineering | |
California Institute of Technology | |
| 9:50 a.m. | HEIDI COOK-ANDERSEN |
Assistant Professor, Reproductive Medicine | |
University of California, San Diego | |
| 10:05 a.m. | Panel Discussion with Speakers and Workshop Participants |
| 10:35 a.m. | Break |
SESSION II: EXAMINING THE DEVELOPMENT OF EXTRAEMBRYONIC LINEAGES
SESSION OBJECTIVES:
- Explore the current state of the science about human extraembryonic lineages and how they are defined and characterized.
- Examine the impact of extraembryonic lineages on human embryo model systems.
Session Moderator: Amander Clark, University of California, Los Angeles
| 10:50 a.m. | R. MICHAEL ROBERTS |
Chancellor’s Professor, Animal Sciences and Biochemistry | |
University of Missouri | |
| 11:05 a.m. | MANA PARAST |
Professor in Residence, Pathology | |
University of California, San Diego | |
| 11:20 a.m. | PAUL ROBSON |
Associate Professor and Director, Single Cell Biology | |
The Jackson Laboratory | |
| 11:35 a.m. | Panel Discussion with Speakers and Workshop Participants |
| 12:05 p.m. | Break for Lunch |
SESSION III: STEM CELL–BASED MODELS OF HUMAN EMBRYOS
SESSION OBJECTIVES:
- Learn about the latest scientific and technical developments with models of human embryos and the direction for future research and applications of this work.
- Examine the fidelity of human embryo model systems to bona fide human embryos and explore methods for validation of the model systems.
Session Moderator: Arnold Kriegstein, University of California, San Francisco
| 1:10 p.m. | ALI BRIVANLOU |
Robert and Harriet Heilbrunn Professor | |
The Rockefeller University | |
| 1:25 p.m. | ARYEH WARMFLASH |
Principal Investigator | |
Assistant Professor, Department of Biosciences | |
Rice University | |
| 1:40 p.m. | NICOLAS RIVRON |
Group Leader, Institute of Molecular Biotechnology | |
Austrian Academy of Sciences |
| 1:55 p.m. | JIANPING FU |
Associate Professor, Biomedical and Mechanical Engineering | |
Associate Professor, Cell and Developmental Biology | |
University of Michigan | |
| 2:10 p.m. | Panel Discussion with Speakers and Workshop Participants |
| 2:40 p.m. | Break |
SESSION IV: COMPARATIVE EMBRYONIC DEVELOPMENT ACROSS SPECIES
SESSION OBJECTIVES:
- Understand the similarities and differences between nonhuman embryos, embryo models (e.g., chimeras), and human embryos.
- Identify scientific questions that may necessitate the study of human embryos.
Session Moderator: Jianping Fu, University of Michigan
| 2:55 p.m. | SHAWN CHAVEZ |
Assistant Professor | |
Division of Reproductive and Developmental Sciences | |
Oregon Health & Science University | |
| 3:10 p.m. | TED GOLOS |
Professor and Chair | |
Department of Comparative Biosciences | |
University of Wisconsin | |
| 3:25 p.m. | MARTÍN GARCÍA CASTRO |
Associate Professor, Biomedical Sciences | |
Univerity of California, Riverside | |
| 3:40 p.m. | JUN WU |
Assistant Professor, Molecular Biology | |
University of Texas Southwestern Medical Center | |
| 3:55 p.m. | Panel Discussion with Speakers and Workshop Participants |
SESSION V: FUTURE OPPORTUNITIES AND CHALLENGES WITH MAMMALIAN EMBRYO MODEL SYSTEMS
SESSION OBJECTIVE:
- Summarize the lessons learned and topics discussed throughout the workshop, and address the key questions shown below.
Key Questions:
- What did we hear today that was new and could be moved forward to help advance the field?
- What was not discussed today that you think is important and key to the development of human embryo model systems?
- What level of fidelity exists between human embryo model systems and bona fide human embryos?
Session Moderator: Nicolas Rivron, Austrian Academy of Sciences
| 4:25 p.m. | Final Panel Discussion |
ALI BRIVANLOU | |
JIANPING FU | |
KATHY NIAKAN | |
MANA PARAST | |
| 4:55 p.m. | Closing Keynote |
MARTIN PERA | |
Professor | |
The Jackson Laboratory | |
| 5:15 p.m. | Clarifying Questions from Workshop Participants |
| 5:25 p.m. | Final Remarks |
JANET ROSSANT | |
Senior Scientist, Developmental and Stem Cell Biology | |
The Hospital for Sick Children | |
| 5:30 p.m. | Adjourn |
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